Dietary Strategies for Metabolic and Cardiovascular Disorders Associated with Metabolic Syndrome

Dear Colleagues,

Metabolic syndrome (MtS) is a clinical condition that appears in 25 % of the adult population in the western world, with increased prevalence in advanced ages. In patients with MtS, the accumulation of adipose tissue creates a pro-inflammatory and pro-oxidative microenvironment that results in chronic subclinical inflammation, dyslipidemia, hypertension, and glucose intolerance. Different adipokines secreted by adipose tissue can alter the function of multiple vasoactive factors, diminishing their synthesis and/or bioavailability, thereby contributing to the progression of cardiovascular diseases and, consequently, leading to end-organ damage.

Several approaches have been traditionally used to prevent or reverse the cardiometabolic alterations associated to MtS. In addition to pharmacological therapy, changes in eating habits and lifestyle are undoubtedly the most important non-pharmacological interventions to prevent or reverse MtS. Improved understanding of pathophysiological mechanisms and the nutritional interventions can identify potential targets to prevent or minimize the metabolic and vascular dysfunction in MtS.

Given the above, this research topic aims to strengthen the understanding of how a dietary intervention, either by itself or in combination with other pharmacological or non-pharmacological interventions, can ameliorate and/or reverse the pathophysiological adjustments involved in changes in vascular tone, inflammation, and remodeling in MtS.

Prof. Dr. Javier Blanco-Rivero
Prof. Dr. Fabiano E. Xavier
Guest Editors

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