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Nutrition, Diet and Metabolism in Pregnancy

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition in Women".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 614

Special Issue Editors


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Guest Editor
Third Department of Obstetrics and Gynecology, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Agiou Dimitriou, 54124 Thessaloniki, Greece
Interests: obstetrics; diet in pregnancy; high-risk pregnancies; perinatal medicine; placental research; fetal medicine

Special Issue Information

Dear Colleagues,

Proper nutrition, diet, and metabolism during pregnancy are fundamental to the health and well-being of both the mother and the developing fetus. Adequate nutritional intake supports fetal growth, influences long-term health outcomes, and reduces the risk of pregnancy-related complications. Advances in understanding the intricate relationship between maternal diet and metabolic processes have highlighted the critical role of specific nutrients, dietary patterns, and metabolic adaptations in optimizing pregnancy outcomes. This area of research is essential for developing evidence-based guidelines and interventions that promote maternal and fetal health.

We are pleased to invite you to contribute to this Special Issue, titled "Nutrition, Diet and Metabolism in Pregnancy", in the journal of Nutrients. Our aim is to assemble a comprehensive collection of the latest research and advancements in the fields of nutrition, diet, and metabolism as they pertain to pregnancy. By focusing on this vital aspect of maternal–fetal health, we seek to highlight innovative approaches, share novel findings, and disseminate knowledge that can inform clinical practices and public health policies to enhance pregnancy outcomes and long-term health for both mothers and their children.

In this Special Issue, we welcome original research articles, systematic reviews, and comprehensive reviews. Potential topics include, but are not limited to, the following:

  • The impact of maternal diet on fetal development;
  • Nutritional requirements and supplementation during pregnancy;
  • Metabolic adaptations in pregnancy and their implications;
  • Dietary interventions for managing gestational diabetes and other metabolic disorders;
  • The role of micronutrients in pregnancy outcomes;
  • Maternal obesity, diet, and metabolic health;
  • The effects of specific dietary patterns on pregnancy and neonatal health;
  • Nutrigenomics and personalized nutrition in pregnancy;
  • The long-term effects of prenatal nutrition on child health;
  • Public health strategies for improving maternal nutrition.

We look forward to receiving your contributions and collaborating to advance the understanding of nutrition, diet, and metabolism in pregnancy through this Special Issue.

Dr. Antonios Siargkas
Dr. Ioannis Tsakiridis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • pregnancy
  • maternal diet
  • gestational nutrition
  • prenatal supplementation
  • dietary interventions
  • pregnancy outcomes
  • micronutrient intake

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Published Papers (2 papers)

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Research

19 pages, 693 KiB  
Article
Evaluating Prevalence of Preterm Postnatal Growth Faltering Using Fenton 2013 and INTERGROWTH-21st Growth Charts with Logistic and Machine Learning Models
by Ioanna Kakatsaki, Nicolina Hilda Anagnostatou, Theano Roumeliotaki, Eleftherios Panteris, Theodoros Liapikos, Styliani Papanikolaou and Eleftheria Hatzidaki
Nutrients 2025, 17(10), 1726; https://doi.org/10.3390/nu17101726 - 20 May 2025
Abstract
Background/Objectives: Postnatal growth faltering (PGF) significantly affects premature neonates, leading to compromised neurodevelopment and an increased risk of long-term health complications. Methods: This retrospective study at a level III NICU of a tertiary hospital analyzed 650 preterm neonates born before 33 weeks. Postnatal [...] Read more.
Background/Objectives: Postnatal growth faltering (PGF) significantly affects premature neonates, leading to compromised neurodevelopment and an increased risk of long-term health complications. Methods: This retrospective study at a level III NICU of a tertiary hospital analyzed 650 preterm neonates born before 33 weeks. Postnatal growth was evaluated using the Fenton2013 and INTERGROWTH-21st growth charts, with changes in weight z-scores from birth to discharge classified as normal growth (ΔZ ≥ −1), non-severe PGF (−2 ≤ ΔZ < −1), and severe PGF (ΔZ < −2). Results: Mean gestational and postmenstrual age at discharge was 30 weeks (SD 1.9) and 37.1 weeks (SD 2.7), respectively. Fenton2013 growth curves revealed a higher prevalence of non-severe and severe PGF (43% and 14.6%) compared to INTERGROWTH-21st (24.5% and 10.3%). A more rapid establishment of full enteral feeds was strongly associated with reduced severe PGF prevalence in both growth charts (p < 0.001), as was shorter hospitalization. Late-onset sepsis was associated with an increased risk of severe PGF, while being small for gestational age (SGA) was protective against severe PGF across both growth charts (p < 0.001). A trend of decreasing PGF prevalence was noted over the study years, most probably attributed to the implementation of updated nutritional guidelines. Interestingly, when machine learning classification models were evaluated in our Greek cohort, a notable decline in predictive accuracy depending on the growth standard applied was observed. Conclusions: Our study highlights the need for standardizing PGF definition in an attempt to enhance nutritional management and further investigate the long-term impacts of nutritional interventions on growth, neurodevelopment, and overall health outcomes. Full article
(This article belongs to the Special Issue Nutrition, Diet and Metabolism in Pregnancy)
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16 pages, 3513 KiB  
Article
Investigating the Impact of Maternal Obesity on Disease Severity in a Mouse Model of Preeclampsia
by Natalie K. Binder, Natasha de Alwis, Bianca R. Fato, Sally Beard, Yeukai T. M. Mangwiro, Elif Kadife, Fiona Brownfoot and Natalie J. Hannan
Nutrients 2025, 17(9), 1586; https://doi.org/10.3390/nu17091586 - 5 May 2025
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Abstract
Background: Preeclampsia is a leading cause of maternal and fetal morbidity and mortality, with obesity recognised as a significant risk factor. However, the direct contribution of obesity to the pathophysiology underpinning preeclampsia remains unclear. Objectives: This study aimed to develop and characterise a [...] Read more.
Background: Preeclampsia is a leading cause of maternal and fetal morbidity and mortality, with obesity recognised as a significant risk factor. However, the direct contribution of obesity to the pathophysiology underpinning preeclampsia remains unclear. Objectives: This study aimed to develop and characterise a diet-induced obese mouse model with superimposed preeclampsia to better understand the impact of obesity on disease pathogenesis. Methods: Female mice were fed either standard rodent chow or a high-fat diet from weaning. At 8 weeks of age, mice were mated. Pregnant mice were treated with L-NG-Nitro arginine methyl ester (L-NAME; to block nitric oxide production) from gestational day (D)7.5 to D17.5 to induce a preeclampsia-like phenotype. Blood pressure was measured on D14.5 and D17.5, followed by the collection of maternal and fetal tissues for histological, biochemical, and molecular analyses. Results: Obese dams exhibited significantly increased body, fat pad, and liver weights compared to lean controls. While L-NAME induced hypertension in the control mice, contrary to expectations, the L-NAME-induced hypertension was partially attenuated in obese dams, with significantly lower systolic and diastolic blood pressures at D14.5 and reduced systolic pressure at D17.5. Fetal weights were comparable between groups, however, placentas were significantly heavier with obesity. Endothelial function, inflammatory markers, and renal gene expression patterns suggested distinct physiological adaptations in obese preeclamptic-like mice. Conclusions: These findings challenge the prevailing assumption that obesity drives hypertension, endothelial dysfunction, and inflammatory markers. The differential vascular and physiological responses observed in the obese dams highlight the complexity of obesity–preeclampsia interactions and underscore the need for refined preclinical models to disentangle mechanistic contributions. This work has implications for personalised management strategies and targeted therapeutic interventions in obese pregnancies at risk of preeclampsia. Full article
(This article belongs to the Special Issue Nutrition, Diet and Metabolism in Pregnancy)
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