Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.2
4.8
Journals
Nutrients
Special Issues
Antioxidants in Diet: Metabolic Impacts and Mechanisms of Action
nutrients-logo
Submit to Special Issue Submit Abstract to Special Issue Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Antioxidants in Diet: Metabolic Impacts and Mechanisms of Action

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 25 May 2025 | Viewed by 3197

Special Issue Editor

Dr. Sita Aggarwal

E-Mail Website
Guest Editor
Department of Chemistry and Physics, Southeastern Louisiana University, Hammond, LA 70402, USA
Interests: plant phytochemicals; inflammation; antioxidants; cancer; diabetes; NSAIDs

Special Issue Information

Dear Colleagues,

What can potentially be a defensive strategy against oxidative damage by reactive oxygen species? The excessive production of reactive oxygen species (superoxide, peroxide, and hydroxyl radical) damages various cellular functions and causes chronic diseases such as diabetes and cancer. Plant phenolic phytochemicals, vitamin C, and vitamin E are antioxidants that decrease oxidative stress by quenching reactive oxygen species. Therefore, edible plants that are rich in phenolic phytochemicals, vitamin C, and vitamin E are beneficial. Considerable evidence showing these phytochemicals are pharmacologically safe but poorly bioavailable in the cells is now available. Large oral doses are safe but are cleared from the system via mechanisms such as glucuronidation. This area needs more attentive research and carries limitless potential in terms of serving as an effective therapeutic for various cancers, diabetes, and obesity.

Dr. Sita Aggarwal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • oxidative stress
  • plant polyphenols
  • metabolic syndrome
  • reactive oxygen species
  • phytochemicals
  • vitamin C
  • vitamin E
  • inflammation
  • cancer
  • diabetes

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

23 pages, 877 KiB  
Article
Nutritional Status of Vitamin E and Its Association with Metabolic Health in Adults
by Kacper Szewczyk, Joanna Bryś, Rita Brzezińska and Magdalena Górnicka
Nutrients 2025, 17(3), 408; https://doi.org/10.3390/nu17030408 - 23 Jan 2025
Cited by 1 | Viewed by 1836
Abstract
Background: Vitamin E is one of the key dietary antioxidants. However, current evidence remains insufficient to establish a definitive relationship between circulating vitamin E levels, body fat content, and their influence on metabolic health. This study aimed to assess and compare the vitamin [...] Read more.
Background: Vitamin E is one of the key dietary antioxidants. However, current evidence remains insufficient to establish a definitive relationship between circulating vitamin E levels, body fat content, and their influence on metabolic health. This study aimed to assess and compare the vitamin E nutritional status in adults with normal and excess body fat and its determinants. Methods: Concentrations of vitamin E isoforms (α- and γ-tocopherols, α- and γ-tocotrienols) were assessed in 127 individuals. Body fat content and other anthropometric indices, as well as biochemical markers such as lipid profile, plasma fatty acid concentration and C-reactive protein, were identified as markers of metabolic health. Participants were divided into two groups: with normal and excess body fat (defined as more than 30% in women and more than 25% in men). Results: The determinants of higher α-tocopherol concentrations were lower body fat content and higher levels of circulating lipids as HDL and LDL (R2 = 0.221, p < 0.001 in a model of multivariate linear regression). The level of circulating vitamin E isoforms correlated with the concentration of CRP (r = −0.464 for α-T, r = −0.453 for αT3, r = −0.270 for γ-T, r = −0.355 for γ-T3). Similarly, elevated concentrations of vitamin E isoforms are linked to lower adipose tissue content, which may contribute to lower inflammation and improved metabolic health (r = −0.359 for α-T, r = −0.333 for αT3, r = −0.276 for γ-T3, no significant correlation for γ-T). Conclusions: These results reveal that the vitamin E status of adults with excess body fat may be inadequate and linked to poorer metabolic health. We found that the determinants of lower plasma vitamin E were higher BF and lower TC and its fraction, with the strongest correlations being found for HDL. Full article
(This article belongs to the Special Issue Antioxidants in Diet: Metabolic Impacts and Mechanisms of Action)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

23 pages, 2966 KiB  
Review
Bioactive Components, Pharmacological Properties, and Applications of Cistanche deserticola Y. C. Ma: A Comprehensive Review
by Xiaofeng Liu, Zichao Yang, Minjun Han, Yao Zhang, Hussain Muhammad, Hao Zhong and Rongfa Guan
Nutrients 2025, 17(9), 1501; https://doi.org/10.3390/nu17091501 (registering DOI) - 29 Apr 2025
Abstract
Cistanche deserticola Y. C. Ma (C. deserticola), a holoparasitic desert plant traditionally revered as “desert ginseng”, has emerged as a versatile resource with significant applications in both medicinal and dietary contexts. This comprehensive review systematically explores its bioactive constituents, including phenylethanol [...] Read more.
Cistanche deserticola Y. C. Ma (C. deserticola), a holoparasitic desert plant traditionally revered as “desert ginseng”, has emerged as a versatile resource with significant applications in both medicinal and dietary contexts. This comprehensive review systematically explores its bioactive constituents, including phenylethanol glycosides (PhGs), iridoids, lignans, and polysaccharides, and elucidates their multifaceted pharmacological properties. Contemporary research substantiates the therapeutic potential of C. deserticola, demonstrating its anti-inflammatory, antioxidant, antitumor, neuroprotective, and immunomodulatory effects. Mechanism analysis elucidated its anti-fatigue and immune-enhancing activities, primarily through the modulation of pivotal signaling pathways, including NF-κB, AMPK, and TLR4. The review also highlights recent regulatory advancements in China, which have approved C. deserticola as a functional food ingredient, complementing its traditional uses in kidney yang tonification and promoting intestinal health. Despite its promising attributes, challenges related to sustainable cultivation and clinical application remain. By integrating ethnopharmacological wisdom with modern scientific evidence, this work lays a robust foundation for advancing the applications of C. deserticola in nutraceuticals and therapeutics. Full article
(This article belongs to the Special Issue Antioxidants in Diet: Metabolic Impacts and Mechanisms of Action)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

8 pages, 802 KiB  
Brief Report
A Preliminary Analysis of the Influence of Elderberry Juice Consumption on Thyroid Metabolism in Mice and Humans Fed High-Fat Diets
by Catherine L. Jarrett, Christy Teets, Franck G. Carbonero, Andrea J. Etter and Patrick M. Solverson
Nutrients 2025, 17(4), 612; https://doi.org/10.3390/nu17040612 - 8 Feb 2025
Viewed by 1117
Abstract
Background/Objectives: Elderberry juice (EBJ) consumption prevents weight gain in mice fed a high-fat diet and increases fat oxidation in response to a meal challenge in overweight humans. Thyroid hormones influence metabolism and substrate oxidation, and the impact of EBJ consumption on thyroid homeostasis [...] Read more.
Background/Objectives: Elderberry juice (EBJ) consumption prevents weight gain in mice fed a high-fat diet and increases fat oxidation in response to a meal challenge in overweight humans. Thyroid hormones influence metabolism and substrate oxidation, and the impact of EBJ consumption on thyroid homeostasis remains unexplored. Thus, the primary objective of this analysis was to investigate whether elderberry consumption in mice and humans affects serum thyroid biomarkers. Methods: Serum samples from a previous trial incorporating an EBJ intervention were analyzed for thyroxine (T4), thyroid stimulating hormone (TSH), and thyroglobulin (Tg). The samples are from a meal-tolerance test in 18 humans who followed a 7-day diet-controlled crossover design. Samples from 33 male mice were collected after 13 weeks following a high-fat diet with or without EBJ powder, and with or without free wheel running. Results: Short-term EBJ consumption in humans resulted in significant increases in T4 (PL: 42.3 ± 3.2 vs. EBJ: 49.3 ± 4.1 ng/mL, p < 0.05), and TSH (PL: 0.094 ± 0.012 vs. EBJ: 0.104 ± 0.011 ng/mL, p < 0.05), with no change in Tg (p > 0.05). Whereas supplementation with EBJ powder in rodents resulted in a non-significant reduction in T4 (p = 0.07). Conclusions: These findings suggest that elderberry juice consumption may influence thyroid metabolism, contributing to the observed metabolic benefits, such as improved fat oxidation, body composition, and protection against high-fat diet-induced weight gain. The increased T4 and TSH in humans align with enhanced metabolic rate, while the reduction in T4 in rodents indicates potential long-term adaptations requiring further exploration. Full article
(This article belongs to the Special Issue Antioxidants in Diet: Metabolic Impacts and Mechanisms of Action)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop