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Impact of Diet, Nutrition and Lifestyle on Reproductive Health—2nd Edition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 25 September 2026 | Viewed by 692

Editors


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Guest Editor
1. NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
2. Department of Obstetrics & Gynaecology, National University Hospital, National University Health System, Singapore 119228, Singapore
3. Temasek Life Sciences Laboratory, Singapore 117604, Singapore
Interests: nutrition; lipidomics; metabolomics; diet; micronutrients and minerals; macronutrients; reproduction; puberty; male fertility; female fertility; menopause
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
2. Department of Obstetrics & Gynaecology, National University Hospital, National University Health System, Singapore 119228, Singapore
Interests: nutrition; exposome; female reproductive health; menopause; women’s health; PCOS; multi-omics; Asian ethnicity; healthy longevity

Special Issue Information

Dear Colleagues,

A balanced diet and good nutrition are essential for the general health, growth and well-being of an individual. Health and longevity have been shown to be closely associated with reproductive health. Boys and girls need to have the correct nutrition and diets tailored to their unique needs during their growing phase. For example, girls should maintain a healthy weight and proper body composition to avoid extreme weights such as obesity, which can lead to early menarche and is associated with long-term health sequelae. Additionally, body weight which is too low is unhealthy and will lead to poor bone mass development. This will result in an elevated risk of osteoporosis. Hence, proper nutrition from a young age may potentially offer the best health shield against chronic diseases and ensure optimal health during conception, pregnancy and delivery. Furthermore, healthy longevity in women and men are different. In particular, menopause in women is the driver for age-associated diseases where adequate and correct nutrition, diet and physical activity is needed to maintain muscle mass, avoid sarcopenia, frailty and metabolic diseases.

The Special Issue (Second Edition) will continue to address the pertinence of diet, nutrition and lifestyle impacts on an individual’s reproductive lifespan and healthspan. We want to offer new insights into the role of diet and nutrition in maintaining and promoting reproductive health and ageing in both men and women throughout their entire lifespan, especially in women from puberty, during the reproductive age and into menopause. Furthermore, with the global fertility crisis and rapidly ageing societies occurring, this Second Edition of the Special Issue will focus on evidence-based reviews, original laboratory and clinical research that explore and derive guidance on the intake of vital micro- and macronutrients, antioxidants and their impact on fertility, reproductive health and ageing. We encourage authors to submit their original research on this essential topic to boost reproductive health and longevity through lifelong healthy nutrition.

Dr. Zhongwei Huang
Dr. Paula Benny
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • lipidomics
  • metabolomics
  • diet
  • micronutrients and minerals
  • macronutrients
  • reproduction
  • puberty
  • reproduction
  • male fertility
  • female fertility
  • menopause
  • ageing
  • healthy longevity

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Published Papers (1 paper)

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Research

15 pages, 2694 KB  
Article
Obesity Triggers Dysregulation of Essential ABC Transporters in Rat Testis and Sperm
by Péter Szatmári, Kata Kira Kemény, Adrienn Seres-Bokor and Eszter Ducza
Nutrients 2026, 18(11), 1829; https://doi.org/10.3390/nu18111829 - 5 Jun 2026
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Abstract
Objectives: Obesity and the associated metabolic dysfunction influence fertility performance at molecular levels and ABC transporters are considered as potential molecular factors affecting fertility both in the testis and sperm; therefore, we aimed to examine the effect of a short-term diet-induced obesity on [...] Read more.
Objectives: Obesity and the associated metabolic dysfunction influence fertility performance at molecular levels and ABC transporters are considered as potential molecular factors affecting fertility both in the testis and sperm; therefore, we aimed to examine the effect of a short-term diet-induced obesity on testicular and spermatic ABC transporters in a rat model focusing on the expressions of P-glycoprotein (P-gp, Abcb1) and breast cancer resistance protein (BCRP, Abcg2). The testicular androgen state involving aromatase enzyme (Cyp19a1), androgen receptor (Ar), and testosterone levels were also evaluated. Methods: Obesity was induced in male Sprague Dawley rats by feeding a high-fat, high-sugar diet (HFHSD) for 10 weeks, and metabolic status was evaluated using a glucose tolerance test. The weight and size of reproductive organs were measured, and Abcb1a/1b, Abcg2, Cyp19a1, and Ar expression in testes or sperm was determined by RT-PCR and Western blotting. At the same time, testosterone levels were measured by ELISA. Results: HFHSD successfully induced higher weight gain with glucose intolerance and reduced reproductive organ size. In obese rats, testicular Abcb1a and Abcb1b mRNA and P-gp protein expression were significantly higher, whereas testicular Abcg2 mRNA levels decreased. Spermatic Abcb1a, Abcb1b and Abcg2 mRNA expression also reduced in obesity. Neither testicular testosterone concentration nor Cyp19a1 and Ar mRNA expression levels changed after the 10-week obesogenic diet compared with controls. Conclusions: Overall, our study revealed infertility-related ABC transporter changes in obese male rats, suggesting that these alterations may predispose obese males to fertility impairments, even before the obesity-induced androgen dysregulation. Full article
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