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Nutrients
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Neurological Disorders: Diets and Nutrition
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Neurological Disorders: Diets and Nutrition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Neuro Sciences".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 767

Special Issue Editor

Dr. Panagiotis Zis

E-Mail Website
Guest Editor
Medical School, University of Cyprus, Nicosia 1678, Cyprus
Interests: neurology; peripheral neuropathy; clinical neurophysiology; pain; medical education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue dedicated to exploring the intersection between neurological disorders, diet, and nutrition. This Special Issue invites researchers, clinicians, and scholars to submit their latest findings, reviews, and theoretical perspectives on how dietary patterns, nutritional interventions, and nutrient-specific mechanisms influence the onset, progression, and management of neurological disorders. Topics may include, but are not limited to, the role of macronutrients and micronutrients, the impact of specific diets (e.g., ketogenic, Mediterranean, or low-FODMAP diets), and the potential of nutraceuticals to mitigate symptoms or enhance cognitive and neurological health.

Submissions of original research, systematic reviews, meta-analyses, and clinical trials are encouraged. We also welcome translational studies that bridge the gap between laboratory findings and clinical practice. By assembling diverse insights into the connection between nutrition and neurological health, this Special Issue aims to advance our understanding and inform future therapeutic strategies for conditions such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy, and other neurological and neuropsychiatric disorders. Join us in shaping a comprehensive resource for this emerging and impactful field.

Dr. Panagiotis Zis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurological disorders
  • dietary patterns
  • nutritional interventions
  • cognitive and neurological health
  • Alzheimer’s disease
  • Parkinson’s disease
  • multiple sclerosis

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Published Papers (2 papers)

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Research

11 pages, 215 KiB  
Article
Effects of Online, Asynchronous Education Modules on Migraine Severity and Elimination Diet Use Among Higher Education Students: An Observational, Pilot Feasibility Study
by Thanh Thanh T. Vo, Amanda K. Jan, Jeffrey Duong, Jenny Sayaseng, Monica Joy, Emily Andrada, Elizabeth Ekpo and Michelle L. Dossett
Nutrients 2025, 17(15), 2432; https://doi.org/10.3390/nu17152432 - 25 Jul 2025
Abstract
Background/Objectives: Migraine is a debilitating neurologic disorder with diet-related triggers. No studies exist on education on migraine in conjunction with an elimination diet as a non-pharmacologic management approach. Methods: Higher education students who self-reported migraine were enrolled in this observational, pilot [...] Read more.
Background/Objectives: Migraine is a debilitating neurologic disorder with diet-related triggers. No studies exist on education on migraine in conjunction with an elimination diet as a non-pharmacologic management approach. Methods: Higher education students who self-reported migraine were enrolled in this observational, pilot feasibility study. At baseline, participants completed questionnaires on demographics, migraine disability, and their understanding of migraine and an elimination diet. After one month of self-paced, asynchronous, online modules, participants were reassessed on their understanding of migraine and an elimination diet. Two months later, participants completed follow-up questionnaires on migraine disability, whether they implemented components of the diet, and any barriers they encountered. Results: Of 66 students who completed baseline measures, 33 completed the modules and all questionnaires. Of participants who completed the study, 100% found the modules helpful in learning about migraine and an elimination diet; 57.6% incorporated aspects of the elimination diet into their lives. Participants had significant (p < 0.001) increases in knowledge both about migraine and an elimination diet. Participants had a potentially clinically significant decrease (14-point MIDAS drop, p = 0.10) in migraine symptoms after completing the educational intervention, with a greater decrease among participants who implemented the elimination diet. Conclusions: It is feasible to design and implement an education intervention on diet for higher education students, though loss to follow-up was high in this population. The majority of participants who completed the modules adopted aspects of an elimination diet, indicating its feasibility. Further studies with a larger sample size powered to assess the efficacy of this approach are needed. Full article
(This article belongs to the Special Issue Neurological Disorders: Diets and Nutrition)
11 pages, 1048 KiB  
Article
Shared Immune and Nutrient Metabolism Pathways Between Autism Spectrum Disorder and Celiac Disease: An In Silico Approach
by Panagiota Sykioti, Panagiotis Zis, Despina Hadjikonstanti, Marios Hadjivassiliou and George D. Vavougios
Nutrients 2025, 17(9), 1439; https://doi.org/10.3390/nu17091439 - 25 Apr 2025
Viewed by 539
Abstract
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication difficulties and repetitive behaviors. Emerging evidence suggests a potential link between ASD and celiac disease (CD), possibly mediated by immune dysregulation and nutrient deficiencies. This study explores the shared biological [...] Read more.
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication difficulties and repetitive behaviors. Emerging evidence suggests a potential link between ASD and celiac disease (CD), possibly mediated by immune dysregulation and nutrient deficiencies. This study explores the shared biological pathways between ASD and CD using an in silico approach. Methods: Gene–disease associations for ASD and CD were retrieved from DisGeNET using MedGen Concept IDs (C1510586 and C0007570, respectively). An over-representation analysis (ORA) was conducted using GeneTrail 3.2 to identify significantly enriched biological pathways, which were then compared for overlap. A false discovery rate (FDR) < 0.05 was considered statistically significant. Results: The gene–disease association analysis identified 536 ASD-related genes and 52 CD-related genes. The ORA revealed several shared biological pathways, including immune pathways, cellular metabolism, and micronutrient processing (e.g., folate, selenium, vitamin A). These findings suggest immune dysfunction and nutrient malabsorption as potential mechanistic links between ASD and CD. Conclusions: The observed pathway overlap supports the hypothesis that immune dysregulation and metabolic disturbances contribute to both ASD and CD. Nutrient deficiencies, driven by CD-associated malabsorption, may exacerbate ASD symptoms. Additionally, sensory processing abnormalities in ASD could impact dietary choices, complicating gluten-free diet adherence. Future studies should validate these findings in clinical cohorts and explore dietary interventions, such as targeted supplementation, to mitigate ASD symptoms in individuals with CD. Full article
(This article belongs to the Special Issue Neurological Disorders: Diets and Nutrition)
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