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Nutrients
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Neurological Disorders: Diets and Nutrition
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Neurological Disorders: Diets and Nutrition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Neuro Sciences".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 656

Special Issue Editor

Dr. Panagiotis Zis

E-Mail Website
Guest Editor
Medical School, University of Cyprus, Nicosia 1678, Cyprus
Interests: neurology; peripheral neuropathy; clinical neurophysiology; pain; medical education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue dedicated to exploring the intersection between neurological disorders, diet, and nutrition. This Special Issue invites researchers, clinicians, and scholars to submit their latest findings, reviews, and theoretical perspectives on how dietary patterns, nutritional interventions, and nutrient-specific mechanisms influence the onset, progression, and management of neurological disorders. Topics may include, but are not limited to, the role of macronutrients and micronutrients, the impact of specific diets (e.g., ketogenic, Mediterranean, or low-FODMAP diets), and the potential of nutraceuticals to mitigate symptoms or enhance cognitive and neurological health.

Submissions of original research, systematic reviews, meta-analyses, and clinical trials are encouraged. We also welcome translational studies that bridge the gap between laboratory findings and clinical practice. By assembling diverse insights into the connection between nutrition and neurological health, this Special Issue aims to advance our understanding and inform future therapeutic strategies for conditions such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy, and other neurological and neuropsychiatric disorders. Join us in shaping a comprehensive resource for this emerging and impactful field.

Dr. Panagiotis Zis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurological disorders
  • dietary patterns
  • nutritional interventions
  • cognitive and neurological health
  • Alzheimer’s disease
  • Parkinson’s disease
  • multiple sclerosis

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Published Papers (1 paper)

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Research

11 pages, 1048 KiB  
Article
Shared Immune and Nutrient Metabolism Pathways Between Autism Spectrum Disorder and Celiac Disease: An In Silico Approach
by Panagiota Sykioti, Panagiotis Zis, Despina Hadjikonstanti, Marios Hadjivassiliou and George D. Vavougios
Nutrients 2025, 17(9), 1439; https://doi.org/10.3390/nu17091439 - 25 Apr 2025
Viewed by 470
Abstract
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication difficulties and repetitive behaviors. Emerging evidence suggests a potential link between ASD and celiac disease (CD), possibly mediated by immune dysregulation and nutrient deficiencies. This study explores the shared biological [...] Read more.
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication difficulties and repetitive behaviors. Emerging evidence suggests a potential link between ASD and celiac disease (CD), possibly mediated by immune dysregulation and nutrient deficiencies. This study explores the shared biological pathways between ASD and CD using an in silico approach. Methods: Gene–disease associations for ASD and CD were retrieved from DisGeNET using MedGen Concept IDs (C1510586 and C0007570, respectively). An over-representation analysis (ORA) was conducted using GeneTrail 3.2 to identify significantly enriched biological pathways, which were then compared for overlap. A false discovery rate (FDR) < 0.05 was considered statistically significant. Results: The gene–disease association analysis identified 536 ASD-related genes and 52 CD-related genes. The ORA revealed several shared biological pathways, including immune pathways, cellular metabolism, and micronutrient processing (e.g., folate, selenium, vitamin A). These findings suggest immune dysfunction and nutrient malabsorption as potential mechanistic links between ASD and CD. Conclusions: The observed pathway overlap supports the hypothesis that immune dysregulation and metabolic disturbances contribute to both ASD and CD. Nutrient deficiencies, driven by CD-associated malabsorption, may exacerbate ASD symptoms. Additionally, sensory processing abnormalities in ASD could impact dietary choices, complicating gluten-free diet adherence. Future studies should validate these findings in clinical cohorts and explore dietary interventions, such as targeted supplementation, to mitigate ASD symptoms in individuals with CD. Full article
(This article belongs to the Special Issue Neurological Disorders: Diets and Nutrition)
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