Anti-Inflammatory Diet and Chronic Inflammation
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".
Deadline for manuscript submissions: 25 January 2026 | Viewed by 1558
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chronic inflammation provides a dominant backdrop to the pathogenesis of several diseases and plays a crucial role. These diseases include inflammatory bowel disease, type 2 diabetes, rheumatoid arthritis, some cancers, and cardiovascular diseases. This pathology (chronic inflammation) is triggered by various abnormalities, such as autoimmune responses, obesity, chronic stress, environmental toxins, and infections through repeated activation of the immune system. Unfortunately, today’s therapies for this ailment, which involve biologics, corticosteroids, and nonsteroidal anti-inflammatory drugs (NSAIDs), are associated with significant limitations, including side-effects, cost, and short-term efficacy, and are based on symptomatic relief.
Lately, reports from studies using dietary interventions in mitigating chronic inflammation demonstrate a potential alternative remedy, with limited side-effects, and addresses the root cause of inflammation. In general, foods such as Moringa, leafy greens, turmeric, nuts, fatty fish, berries, and turmeric have phytochemicals and compounds with anti-inflammatory properties. These dietary components act through their myriad phytochemicals and biologics to mitigate chronic inflammation through the blockage of numerous inflammatory pathways, such as the nuclear factor-kappa B (NF-κB) signaling pathway and the proinflammatory cytokine pathways (TNF-a, IL-6). Of note, these compounds and biologics collectively favor a balanced immune response and include flavonoids, polyphenols, omega-3 fatty acids, curcumin, and modulation of the microbiota.
However, to fully realize the full potential of dietary intervention, we need to understand the underlying mechanisms through which dietary ingredients exert their anti-inflammatory effects, as well as undertake more double-blind clinical trials. These two conditions could potentially pave the way for much safer and cost-effective therapies that could be used to either complement existing therapies or act on their own. This Special Issue reviews several basic and clinical studies by leading authors that have studied various foods with anti-inflammatory activities around the globe, their underlying mechanisms, limitations, and their potential applications in clinical settings.
Dr. Chishimba Nathan Mowa
Guest Editor
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Keywords
- chronic inflammation
- diet
- nutrition
- anti-inflammation
- phytochemicals
- moringa
- pathogenesis
- mechanism
- pathways
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