Protein Diet and Keto-Analogues in Chronic Kidney Disease
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Proteins and Amino Acids".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 64
Special Issue Editor
Interests: clinical nephrology; peritoneal dialysis; hemodialysis; dialysis; acute kidney injury; chronic kidney failure; hypertension; chronic disease epidemiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) is a recognized global public health priority due to its epidemiological burden, high morbidity, and cardiovascular mortality.
The most evident consequence of the epidemiological impact of CKD concerns the growing number of patients who will require renal replacement therapy (RRT), which is expected to reach approximately 4 million worldwide in the next 10 years.
In this challenging scenario, nutritional dietary therapy remains a cornerstone of CKD management, used to delay the need for dialysis by reducing uremic toxicity and improving overall metabolic health.
A key nutritional strategy involves reducing one’s protein intake, which is essential in optimizing metabolic control and managing CKD-related complications, such as mineral imbalances, anemia, and acidosis. Notably, supplementing a low-protein diet with keto-analogues can help lower protein intake while preventing sarcopenia and muscle weakness.
A supplemented low-protein diet could serve as an innovative nutritional strategy for patients beginning renal replacement therapy, particularly those with sufficient residual kidney function. It can help reduce the dialysis dose needed while still ensuring adequate treatment. A lower dialysis dose, generally called incremental dialysis, has numerous benefits, including lower dialysis burdens and enhanced acceptance and quality of life among patients beginning peritoneal dialysis or hemodialysis.
This Special Issue of Nutrients will expand our knowledge of protein intake and keto-analogues across the spectrum of CKD, including non-dialysis CKD cohorts, patients receiving peritoneal dialysis or hemodialysis, and kidney transplant recipients.
Our objective is to promote and support research on the management of CKD patients, a topic that is currently undervalued.
Dr. Silvio Borrelli
Guest Editor
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Keywords
- chronic kidney disease (CKD)
- renal replacement therapy (RRT)
- dialysis
- hemodialysis
- CKD-related complications
- nutritional therapy
- low-protein diet (LPD)
- keto-analogues
- protein intake
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