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Functional Foods, Obesity and Gut Microbiota: Mechanisms and Interventions

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics, Probiotics and Postbiotics".

Deadline for manuscript submissions: 25 August 2026 | Viewed by 896

Editor

College of Food Science and Engineering, Northwest A&F University, Xianyang 712100, China
Interests: probiotics; functional foods; fermentation; food biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obesity is a complex metabolic disorder driven by multifactorial interactions among dietary factors, host physiology, and the gut microbiota. Increasing evidence indicates that functional foods play an important role in modulating obesity-related metabolic outcomes, largely through their effects on the composition, function, and metabolic activity of the gut microbiota. However, the mechanistic pathways linking functional food components, microbial responses, and host metabolism remain incompletely understood.

This Special Issue aims to provide a comprehensive and mechanistic perspective on the interactions between functional foods, gut microbiota, and obesity. We welcome original research articles and critical reviews that elucidate how bioactive components in functional foods, such as probiotics, prebiotics, postbiotics, dietary fibers, polyphenols, peptides, and other microbiota-accessible substrates, regulate host energy metabolism, lipid and glucose homeostasis, immune function, and intestinal barrier integrity through microbiota-mediated mechanisms.

Topics of interest include, but are not limited to, functional food–microbiota interactions, microbial-derived metabolites, fermented foods, and microbiota-targeted dietary interventions for obesity prevention and metabolic regulation. Studies employing multi-omics approaches, controlled animal models, and well-designed human intervention trials are particularly encouraged.

Dr. Bo Zhang
Guest Editor

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Keywords

  • gut microbiota
  • probiotics
  • Bifidobacterium
  • diet-induced obesity
  • metabolic health
  • functional foods
  • diet–microbiota interactions
  • fermented dairy products

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Published Papers (1 paper)

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Research

27 pages, 9643 KB  
Article
Konjac Glucomannan–Montmorillonite Hybrids as a Gut-Targeted Therapy for Addressing Diet-Induced Obesity in Mice
by Amin Ariaee, Hannah R. Wardill, Alex Hunter, Anthony Wignall, Aurelia S. Elz, Amanda J. Page, Clive Prestidge and Paul Joyce
Nutrients 2026, 18(8), 1298; https://doi.org/10.3390/nu18081298 - 20 Apr 2026
Viewed by 589
Abstract
Background/Objectives: The growing prevalence of obesity necessitates innovative gut-targeted material strategies to modulate diet-associated metabolic dysfunction. This study investigates a spray-dried konjac glucomannan–montmorillonite (KGM-MMT) hybrid designed to integrate fermentable polysaccharide properties with luminal lipid-adsorptive clay functions within a single micro-engineered formulation. Methods: [...] Read more.
Background/Objectives: The growing prevalence of obesity necessitates innovative gut-targeted material strategies to modulate diet-associated metabolic dysfunction. This study investigates a spray-dried konjac glucomannan–montmorillonite (KGM-MMT) hybrid designed to integrate fermentable polysaccharide properties with luminal lipid-adsorptive clay functions within a single micro-engineered formulation. Methods: In HFD-fed mice treated for 42 days with 2% w/w KGM-MMT, cumulative body weight gain was attenuated by 7.6%, with an AUC of 5094 ± 52.95, compared to 5513 ± 81.35 in HFD controls (p < 0.0001). Results: Serum IL-6 concentrations were reduced by 97% (p = 0.0002), while blood glucose decreased by 46% (p < 0.0001); these effects were greater than those observed with MMT (24%, p = 0.0271) and KGM (16%, ns). Gut microbiota profiling demonstrated a significant 6.2-log2-fold increase in Lactobacillaceae (p = 0.023) and a 2.4-log2-fold increase in Enterococcaceae (p = 0.015) following KGM-MMT treatment. Functional shifts inferred from 16S rRNA gene-based prediction indicated a 1.9-fold increase in short-chain fatty acid-related pathways and a 5.4-fold increase in bile acid deconjugation pathways. Conclusions: Although the KGM-MMT hybrid did not consistently outperform its individual components across all endpoints, it consolidated complementary KGM- and MMT-associated effects within a single dosage form. These findings support spray-dried KGM-MMT as a gut-targeted biomaterial strategy that integrates multiple luminal and microbiota-associated functions within a single formulation. Future studies should define dose–response relationships, validate microbiota-derived functional predictions using higher-resolution approaches, and assess durability and safety under longer-term exposure. Full article
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