Special Issue "Nutrition and Chronic Kidney Disease (CKD)"

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: 15 October 2019.

Special Issue Editors

Guest Editor
Prof. Dr. Martin de Borst Website E-Mail
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands
Interests: chronic kidney disease; kidney transplantation; nutrition; bone and mineral metabolism; phosphate; fibroblast growth factor 23; potassium; genetics
Guest Editor
Prof. Dr. Stephan Bakker Website E-Mail
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713GZ Groningen, The Netherlands
Interests: chronic kidney disease; kidney transplantation; nutrition; metabolic syndrome; small molecules

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) affects more than 850 million people worldwide. CKD is characterized by a high burden in terms of disease load, co-morbidities, mortality risk, and high costs. The excess cardiovascular disease and mortality risk is at least in part explained by metabolic derangements. Diabetes and hypertension—the two most prominent causes of CKD in the Western world—lead to disturbances in glucose, volume, and electrolyte homeostasis. Deregulated mineral metabolism, which is common in CKD, promotes vascular calcification, which further contributes to the excess cardiovascular risk. Emerging data indicate that many of these factors are at least in part modifiable by dietary interventions. However, to what extent dietary interventions are able to reduce cardio-renal risk in CKD remains unclear. Moreover, the question remains as to how such interventions can be translated into realistic dietary recommendations that are manageable for patients.

This Special Issue will focus on dietary factors that play a key role in the etiology of cardio-renal adverse outcomes in CKD, as actionable targets for intervention in clinical practice. The Issue will contain original research papers and state-of-the-art review papers on various aspects of nutrition in the context of CKD and kidney transplantation.

Prof. Dr. Martin de Borst
Prof. Dr. Stephan Bakker
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • kidney transplantation
  • renal nutrition
  • cardiovascular disease
  • epidemiology

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Open AccessArticle
Urinary Taurine Excretion and Risk of Late Graft Failure in Renal Transplant Recipients
Nutrients 2019, 11(9), 2212; https://doi.org/10.3390/nu11092212 - 13 Sep 2019
Abstract
Taurine is a sulfur containing nutrient that has been shown to protect against oxidative stress, which has been implicated in the pathophysiology leading to late graft failure after renal transplantation. We prospectively investigated whether high urinary taurine excretion, reflecting high taurine intake, is [...] Read more.
Taurine is a sulfur containing nutrient that has been shown to protect against oxidative stress, which has been implicated in the pathophysiology leading to late graft failure after renal transplantation. We prospectively investigated whether high urinary taurine excretion, reflecting high taurine intake, is associated with low risk for development of late graft failure in renal transplant recipients (RTR). Urinary taurine excretion was measured in a longitudinal cohort of 678 stable RTR. Prospective associations were assessed using Cox regression analyses. Graft failure was defined as the start of dialysis or re-transplantation. In RTR (58% male, 53 ± 13 years old, estimated glomerular filtration rate (eGFR) 45 ± 19 mL/min/1.73 m2), urinary taurine excretion (533 (210–946) µmol/24 h) was significantly associated with serum free sulfhydryl groups (β = 0.126; P = 0.001). During median follow-up for 5.3 (4.5–6.0) years, 83 (12%) patients developed graft failure. In Cox regression analyses, urinary taurine excretion was inversely associated with graft failure (hazard ratio: 0.74 (0.67–0.82); P < 0.001). This association remained significant independent of potential confounders. High urinary taurine excretion is associated with low risk of late graft failure in RTR. Therefore, increasing taurine intake may potentially support graft survival in RTR. Further studies are warranted to determine the underlying mechanisms and the potential of taurine supplementation. Full article
(This article belongs to the Special Issue Nutrition and Chronic Kidney Disease (CKD))
Show Figures

Figure 1

Open AccessArticle
Comparing the Effect of Folic Acid and Pentoxifylline on Delaying Dialysis Initiation in Patients with Advanced Chronic Kidney Disease
Nutrients 2019, 11(9), 2192; https://doi.org/10.3390/nu11092192 - 12 Sep 2019
Abstract
Background: We hypothesized that the nutrient loss and chronic inflammation status may stimulate progression in advanced chronic kidney disease. Therefore, we aimed to generate a study to state the influence of combined nutritional and anti-inflammatory interventions. Methods: The registry from the National Health [...] Read more.
Background: We hypothesized that the nutrient loss and chronic inflammation status may stimulate progression in advanced chronic kidney disease. Therefore, we aimed to generate a study to state the influence of combined nutritional and anti-inflammatory interventions. Methods: The registry from the National Health Insurance Research Database in Taiwan was searched for 20–90 years individuals who had certified end-stage renal disease. From January 2005 through December 2010, the diagnosis code ICD-9 585 (chronic kidney disease, CKD) plus erythropoiesis-stimulating agent (ESA) use was defined as entering advanced chronic kidney disease. The ESA starting date was defined as the first index date, whereas the initiation day of maintenance dialysis was defined as the second index date. The duration between the index dates was analyzed in different medical treatments. Results: There were 10,954 patients analyzed. The combination therapy resulted in the longest duration (n = 2184, median 145 days, p < 0.001) before the dialysis initiation compared with folic acid (n = 5073, median 111 days), pentoxifylline (n = 1119, median 102 days, p = 0.654), and no drug group (control, n = 2578, median 89 days, p < 0.001). Lacking eGFR data and the retrospective nature are important limitations. Conclusions: In patients with advanced CKD on the ESA treatment, the combination of folic acid and pentoxifylline was associated with delayed initiation of hemodialysis. Full article
(This article belongs to the Special Issue Nutrition and Chronic Kidney Disease (CKD))
Show Figures

Figure 1

Back to TopTop