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Bidirectional Link Between Eating Habits, Lifestyle, Physical Exercise and Depression and Other Mental Disorders—2nd Edition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (25 August 2025) | Viewed by 2049

Special Issue Editors


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Guest Editor
Clinical Psychology, Clinical Psychophysiology, and Clinical Neuropsychology Laboratory, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy
Interests: nutrition; psychopathology; mental illness; mood disorders; clinical health psychology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Clinical Psychology, Clinical Psychophysiology, and Clinical Neuropsychology Laboratory, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy
Interests: clinical psychology; clinical neuropsychology

Special Issue Information

Dear Colleagues,

Globally, approximately 280 million people suffer from depression and 301 million suffer from anxiety, with a prevalence of 4.4% and 3.6%, respectively (WHO, 2019). These data are even more alarming when we consider that the COVID-19 pandemic dramatically exacerbated experiences of mental illness. Depression has many causes. As a condition that affects psychophysical balance, it can be traced back to mental discomfort. However, it can also be linked to biological deficits. More specifically, deflected moods associated with marked psychopathology can lead to serious behavioral and autonomic manifestations, such as social withdrawal, apathy, asthenia, and anhedonia. Sometimes, specific medical conditions or nutritional deficiencies can generate mood alterations as secondary pathologies; for example, some nutritional deficiencies related to the poor absorption or intake of specific micronutrients (such as vitamins in group B and D) can mimic a depressive episode, manifesting as deficits in concentration and other cognitive symptoms.

In many cases, intakes of specific nutrients and micronutrients can be fundamental, especially if the primary alterations are biological and autonomic. In other cases, an optimal lifestyle can assist traditional therapies or replace them in critical periods (adolescence, post partum, etc.). Furthermore, sporting activities can promote mental health by facilitating the release of specific neurotransmitters that can make the autonomic nervous system more resilient.

Additionally, psychopathological conditions related to eating and obsessive–compulsive spectrum disorders (such as orthorexia) can lead to serious organic impairments.

Considering the success of the previous Special Issue, entitled “Bidirectional Link Between Eating Habits, Lifestyle, Physical Exercise and Depression and Other Mental Disorders”, we are pleased to announce that we are launching a second Special Issue on this topic. Our objective for this Special Issue is to publish selected articles detailing specific aspects of nutrition and other lifestyle interventions, such as participation in physical activity. Contributions describing the effects of mental health on lifestyle and physical health are welcome, as are works illustrating how specific nutrients and micronutrients can promote better psycho-physical well-being.

Prof. Dr. Carlo Pruneti
Dr. Sara Guidotti
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • depression
  • eating habits
  • lifestyle
  • physical activity
  • body–mind integration
  • autonomic imbalance
  • non-pharmacological treatments
  • nutritional deficit
  • biological abnormalities
  • psychopathology

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Published Papers (2 papers)

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Research

27 pages, 3791 KB  
Article
Effects of Blueberry Supplementation on Depression and Anxiety Symptoms in a Rural Louisiana Population
by Katy E. Venable, D. Parker Kelley, Alec Jeansonne, Robbie Beyl, Samia O’Bryan, Venugopal Vatsavayi, Samuel Jones, Charles C. Lee and Joseph Francis
Nutrients 2025, 17(23), 3720; https://doi.org/10.3390/nu17233720 - 27 Nov 2025
Viewed by 801
Abstract
Background/Objectives: Blueberries are an important nutraceutical due to their excellent nutritional profile, with particularly high levels of polyphenols and anthocyanins. These compounds can improve mood, cognition, and health. As such, blueberry consumption can potentially benefit those coping with depression and anxiety. In [...] Read more.
Background/Objectives: Blueberries are an important nutraceutical due to their excellent nutritional profile, with particularly high levels of polyphenols and anthocyanins. These compounds can improve mood, cognition, and health. As such, blueberry consumption can potentially benefit those coping with depression and anxiety. In this regard, there is an unmet need for novel, effective, and accessible treatments for these conditions, particularly in rural communities, where specialized health care is often limited. Methods: Therefore, we conducted a double-blind, randomized pilot study in a rural population to assess whether daily blueberry supplementation affected symptoms of anxiety and depression. We employed a crossover design to test the effects of 12 weeks daily ingestion of 24 g of whole freeze-dried blueberry powder versus placebo on symptoms of depression and anxiety in those diagnosed with a depressive or anxiety disorder including major depressive disorder (MDD) and generalized anxiety disorder (GAD). We collected behavioral data (HDRS, GAD-7, MDI) at baseline, mid-, and post-treatment timepoints. We collected blood, serum, plasma, and behavioral data (HDRS, GAD-7, MDI) at baseline, mid-, and post-treatment timepoints. We measured inflammatory cytokines IL-1β, IL-6, TNF-α, IFN-γ, and IL-10 in serum, CRP in whole blood, and performed global metabolomics in plasma. Results: Blueberries significantly reduced symptoms of depression and anxiety compared to placebo. CRP and inflammatory cytokine levels were unaffected. Our global metabolomic measures suggested that different metabolites were differentially affected at the middle and post-intervention timepoints in the study. Conclusions: Overall, this study found potential improvements in symptoms of depression and anxiety following daily blueberry supplementation, although the biochemical mechanisms underlying these behavioral improvements remain unresolved. Full article
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12 pages, 783 KB  
Article
Decreased Memory Suppression Ability in Restrained Eaters on Food Information—Evidence from ERP Experiment
by Qi Qi, Ke Cui, Li Luo, Yong Liu and Jia Zhao
Nutrients 2025, 17(15), 2523; https://doi.org/10.3390/nu17152523 - 31 Jul 2025
Viewed by 730
Abstract
Background/Objectives: Food-related memory influences appetite regulation, with memory inhibition potentially reducing cravings. While obesity is linked to inhibitory deficits, how restrained eating affects memory suppression in healthy-weight individuals remains unclear. This study examined the cognitive and neural mechanisms of food-memory suppression in young [...] Read more.
Background/Objectives: Food-related memory influences appetite regulation, with memory inhibition potentially reducing cravings. While obesity is linked to inhibitory deficits, how restrained eating affects memory suppression in healthy-weight individuals remains unclear. This study examined the cognitive and neural mechanisms of food-memory suppression in young women. Methods: Forty-two female participants completed a think/no-think task with high-/low-calorie food cues while an EEG was recorded. Event-related potentials (ERPs) were assessed and time–frequency analyses (theta/beta oscillations) were performed. Results: Restrained eaters showed reduced memory control for both food types. The ERP analysis revealed significant N200 amplitude differences between think/no-think conditions (p = 0.03) and a significant interaction between food calories and think/no-think conditions (p = 0.032). Theta oscillations differed by group, food calories, and conditions (p = 0.038), while beta oscillations reflected food-cue processing variations. Conclusions: In conclusion, restrained eaters exhibit distinct neural processing and attenuated food-memory suppression. These results elucidate the neurocognitive mechanisms underlying dietary behavior, suggesting that targeted interventions for maladaptive eating could strengthen memory inhibition. Full article
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