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Nutrients
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Nutritional Perspectives in Obesity Treatments
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Nutritional Perspectives in Obesity Treatments

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 1785

Special Issue Editors

Dr. Shiri Sherf-Dagan

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Guest Editor
1. Department of Nutrition Sciences, School of Health Sciences, Ariel University, Ariel, Israel
2. Department of Nutrition, Assuta Medical Center, Tel Aviv, Israel
Interests: obesity; bariatric surgery; weight bias; nutrition; epidemiology
Special Issues, Collections and Topics in MDPI journals
Dr. Tair Ben-Porat

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Guest Editor
School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel
Interests: obesity and related chronic diseases; human nutrition and metabolism; behavioral change interventions for obesity; maladaptive eating behaviors; clinical trials; evidence synthesis studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obesity is a complex disease requiring a multifaceted treatment approach. Nutrition plays a pivotal role in all obesity management strategies, including lifestyle modifications, obesity management medications, endoscopic procedures, and metabolic bariatric surgery. A deep understanding of nutrition’s role is essential for addressing obesity's complexities, managing comorbidities, and tailoring effective interventions for diverse populations.

This Special Issue, "Nutritional Perspectives in Obesity Treatments", seeks original research and reviews that examine innovative and traditional nutritional approaches in obesity care. We encourage submissions focusing on personalized dietary interventions, strategies to improve adherence, the impact of specific nutrients and micronutrient supplementation, and the integration of nutritional therapy with other obesity treatments. Interdisciplinary insights addressing cultural, psychological, and socioeconomic factors are also welcome.

Our goal is to advance understanding, foster collaboration, and improve patient outcomes by exploring the critical role of nutrition in comprehensive obesity care.

Dr. Shiri Sherf-Dagan
Dr. Tair Ben-Porat
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • metabolic bariatric surgery
  • obesity pharmacotherapy
  • intervention
  • nutrition

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Published Papers (1 paper)

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Review

13 pages, 952 KiB  
Review
Unintended Consequences of Obesity Pharmacotherapy: A Nutritional Approach to Ensuring Better Patient Outcomes
by Werd Al-Najim, António Raposo, Mona N. BinMowyna and Carel W. le Roux
Nutrients 2025, 17(11), 1934; https://doi.org/10.3390/nu17111934 - 5 Jun 2025
Viewed by 1586
Abstract
Background/Objectives: Obesity pharmacotherapy vastly improved the treatment of the disease of obesity. However, GLP-1 receptor agonists and GIP/GLP-1 dual agonists may lead to nutritional complications, including severe caloric restriction, micronutrient deficiencies, lean body mass loss, dehydration, and ketosis. We examine these risks and [...] Read more.
Background/Objectives: Obesity pharmacotherapy vastly improved the treatment of the disease of obesity. However, GLP-1 receptor agonists and GIP/GLP-1 dual agonists may lead to nutritional complications, including severe caloric restriction, micronutrient deficiencies, lean body mass loss, dehydration, and ketosis. We examine these risks and outlines dietitian-led strategies to support improved safety and effectiveness. Methods: This narrative review was conducted in three stages: literature search, screening of abstracts and full texts, and synthesis of findings. Searches were carried out in April and May 2025 across PubMed, Embase, Scopus, ScienceDirect, Web of Science, and Google Scholar using keywords related to obesity pharmacotherapy and nutrition. Results: Clinical observations and trial data suggest that some individuals may consume fewer than 800 kcal/day during the initial stages of treatment. Prolonged energy and protein deficits can increase the risk of sarcopenia, metabolic dysfunction, and reduce treatment adherence. Additional risks include inadequate micronutrient intake due to reduced dietary variety, dehydration linked to gastrointestinal symptoms and hypodipsia, and rare but serious cases of ketoacidosis. Patients at heightened risk include older adults, those with low baseline muscle mass, and individuals with restrictive eating patterns. Conclusions: Obesity medications introduce unique nutritional risks that are not yet addressed by standardised clinical protocols. Registered dietitians play a critical role in assessing intake patterns, monitoring for red flags, and delivering targeted nutritional support. Integrating structured dietary assessment tools, checklists, and risk-specific guidance into pharmacotherapy pathways can enhance safety, promote adherence, and improve long-term outcomes. Full article
(This article belongs to the Special Issue Nutritional Perspectives in Obesity Treatments)
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