Nutritional Modulation of Metabolic Pathways in Chronic Diseases
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 9
Special Issue Editor
Interests: type 2 diabetes; obesity; insulin resistance; metabolic syndrome; cardiovascular risk in metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic, non-communicable diseases are long-term conditions with complex causes, among which an unhealthy lifestyle is a significant factor. Despite our extensive understanding of these diseases’ underlying mechanisms, they continue to be highly prevalent worldwide and account for three-quarters of all deaths globally, many of which occur in relatively young individuals. Nowadays, even though it is common knowledge that poor nutrition is often a central predisposing factor leading to chronic disease development, an efficient solution to this problem remains distant. With the huge discrepancy between the high number of cases and limited healthcare resources, humankind needs suitable yet affordable methods for early diagnosis, ideally identifying predisposing factors for chronic diseases or at least subclinical changes that occur before such diseases become overt. In recent years, research has shown that changes in metabolic profiles almost always accompany pathological conditions; the area of biomarker discovery has undergone exponential growth, even establishing an entirely new field of metabolomics. These metabolic pathways must be efficiently modulated, with the aim of progressively reducing the incidence and severity of chronic diseases. Since such efficiency is granted by low costs, availability in low- and middle-income countries, and a high preventive value, nutrition and nutrient optimisation undoubtedly count among the most effective interventions. One of the latest examples of the simplicity and success of nutritional optimisation is the discovery of the high health potential provided by balanced eating patterns. Therefore, this Special Issue focuses specifically on the essential role that nutrition plays in modulating pathophysiology pathways leading to chronic diseases, aiming to depict them from the broadest perspective, starting with a molecular, preclinical approach and extending all the way to clinical viewpoints that centre on this connection.
Dr. Cristina-Mihaela Lăcătuşu
Guest Editor
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Keywords
- nutritional intervention
- dietary patterns
- eating habits
- dietary intervention
- healthy eating plan
- metabolic pathways
- metabolites
- metabolomics
- metabolic profiling
- metabolic remodelling
- metabolic reprogramming
- biomarkers
- non-communicable diseases
- chronic diseases
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