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Nutrition, Exercise, and Health: Nutritional Supplements, Exercise Training, Skeletal Muscle Health, and Performance

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Sports Nutrition".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 120

Special Issue Editors


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Guest Editor
Department of Kinesiology, New Mexico State University, Las Cruces, NM 88003, USA
Interests: exercise; aging; skeletal muscle; dietary supplements
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA 90045, USA
Interests: exercise; rehabilitation; brain function; musculoskeletal injury; neuromechanics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The synergistic relationship between nutrition and exercise is pivotal for optimizing skeletal muscle health and overall well-being. We invite researchers to contribute original research articles, reviews, and perspectives to our upcoming issue exploring this dynamic interplay between nutritional supplements, exercise, skeletal muscle health, and performance. This Special Issue aims at highlighting recent advancements in nutritional and/or dietary strategies and training interventions, emphasizing their combined effects on metabolism, muscle adaptation, physical function, and overall health.

Topics of interest include, but are not limited to, the following:

  • The influence of nutritional supplements on exercise performance, recovery, and muscle function.
  • The role of resistance and endurance training in nutrient utilization and skeletal muscle adaptation.
  • The impact of dietary patterns on metabolic health, inflammation, and musculoskeletal integrity.
  • Mechanisms underlying exercise-induced muscle hypertrophy, muscle preservation, and recovery through nutritional interventions.
  • The effects of combined dietary and exercise strategies in aging populations, athletes, and individuals with chronic conditions.

This Special Issue serves as a platform to showcase cutting-edge research bridging nutrition and exercise science to enhance physical performance and overall health. We welcome interdisciplinary submissions from the fields of exercise physiology, sports nutrition, kinesiology, and metabolic health, particularly studies that investigate the association between nutrition, exercise training, and holistic well-being. 

Dr. Sang-Rok Lee
Guest Editor

Dr. Yong Woo An
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutritional supplements
  • exercise training
  • exercise intervention
  • skeletal muscle function
  • dietary patterns
  • physical performance
  • metabolomics
  • well-being

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Published Papers (1 paper)

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Review

27 pages, 1147 KiB  
Review
From Fish Oil to Resolution: A Narrative Review on the Potential of SPM-Enriched Marine Oil for Exercise-Induced Muscle Damage Recovery
by Leticia C. de Souza, Jose M. Moris, Paul M. Gordon, Jeffery L. Heileson and LesLee K. Funderburk
Nutrients 2025, 17(12), 2014; https://doi.org/10.3390/nu17122014 - 16 Jun 2025
Abstract
Exercise-induced muscle damage (EIMD) initiates an inflammatory response that is essential for tissue repair. However, when prolonged or excessive, this response can impair recovery and muscular performance. Specialized pro-resolving mediators (SPMs), derived from the metabolism of omega-3 (n-3) polyunsaturated fatty acids [...] Read more.
Exercise-induced muscle damage (EIMD) initiates an inflammatory response that is essential for tissue repair. However, when prolonged or excessive, this response can impair recovery and muscular performance. Specialized pro-resolving mediators (SPMs), derived from the metabolism of omega-3 (n-3) polyunsaturated fatty acids (PUFAs), facilitate the resolution of inflammation without causing immunosuppression. Evidence from preclinical studies indicates that SPM administration accelerates muscle repair and functional recovery by enhancing the clearance of apoptotic cells, suppressing pro-inflammatory signaling and modulating macrophage polarization. However, translation to human applications remains limited as commercially available SPM-enriched marine oils do not contain active SPMs but rather their monohydroxylated precursors, including 14-Hydroxy-Docosahexaenoic Acid (14-HDHA), 17-Hydroxy-Docosahexaenoic Acid (17-HDHA), and 18-Hydroxy-Eicosapentaenoic Acid (18-HEPE) in addition to low doses of the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Furthermore, the variable increases in circulating SPM concentrations as a result of dietary intake of EPA and DHA, whether from fish or fish oil supplements, and the wide diversity of SPM molecules (many of which remain under investigation), highlight the complexity of their structural and functional networks. While advances in lipidomics have identified SPMs and their pathway intermediates in human biological samples, further research is needed to determine optimal dosing strategies, delivery mechanisms, and the real impact of SPM-enriched marine oil on athletic performance and recovery. This narrative review examines the biological rationale and current evidence surrounding SPM-enriched marine oil supplementation and its potential to enhance muscle recovery following EIMD. By synthesizing findings from preclinical and human studies, the potential of SPM-enriched supplementation as a novel tool for optimizing performance recovery in athletic populations is reviewed to inform future research directions. Full article
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