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Anti-Aging Activity of Food Components and Its Molecular Basis

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 5 April 2025 | Viewed by 1755

Special Issue Editor


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Guest Editor
Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Interests: anti-aging; functional foods; sirtuin; brain foods; polyphenol
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, various foods and food-derived components have been reported to exhibit health benefits and even anti-aging effects. In particular, it has become clear that some foods and food-derived components not only exhibit anti-aging effects on various organs and tissues, such as the brain, muscles, skin and intestines, but also activate interactions among them, and many studies have recently been reported that have clarified the molecular basis of these effects. In this Special Issue, we would like to accept research that approaches the clarification of various anti-aging effects shown by various food components and their molecular basis or the mechanism of activation of interactions between organs and tissues by food components or their networks. We welcome your contributions.

Prof. Dr. Yoshinori Katakura
Guest Editor

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Keywords

  • ant-aging
  • food-derived factor
  • exosome
  • miRNA
  • brain–gut interaction
  • inter-organ interaction

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Published Papers (1 paper)

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Research

15 pages, 17616 KiB  
Article
Activation of the Gut–Brain Interaction by Urolithin A and Its Molecular Basis
by Daiki Kubota, Momoka Sato, Miyako Udono, Akiko Kohara, Masatake Kudoh, Yuichi Ukawa, Kiichiro Teruya and Yoshinori Katakura
Nutrients 2024, 16(19), 3369; https://doi.org/10.3390/nu16193369 - 3 Oct 2024
Viewed by 1323
Abstract
Background: Urolithin A (Uro-A), a type of polyphenol derived from pomegranate, is known to improve memory function when ingested, in addition to its direct effect on the skin epidermal cells through the activation of longevity gene SIRT1. However, the molI ecular mechanism by [...] Read more.
Background: Urolithin A (Uro-A), a type of polyphenol derived from pomegranate, is known to improve memory function when ingested, in addition to its direct effect on the skin epidermal cells through the activation of longevity gene SIRT1. However, the molI ecular mechanism by which orally ingested Uro-A inhibits cognitive decline via the intestine remains unexplored. Objectives: This study aimed to evaluate the role of Uro-A in improving cognitive function via improved intestinal function and the effect of Uro-A on the inflammation levels and gene expression in hippocampus. Methods: Research to clarify the molecular basis of the functionality of Uro-A was also conducted. Results: The results demonstrated that Uro-A suppressed age-related memory impairment in Aged mice (C57BL/6J Jcl, male, 83 weeks old) by reducing inflammation and altering hippocampal gene expression. Furthermore, exosomes derived from intestinal cells treated with Uro-A and from the serum of Aged mice fed with Uro-A both activated neuronal cells, suggesting that exosomes are promising candidates as mediators of the Uro-A-induced activation of gut–brain interactions. Additionally, neurotrophic factors secreted from intestinal cells may contribute to the Uro-A-induced activation of gut–brain interactions. Conclusions: This study suggests that Uro-A suppresses age-related cognitive decline and that exosomes and other secreted factors may contribute to the activation of the gut–brain interaction. These findings provide new insights into the therapeutic potential of Uro-A for cognitive health. Full article
(This article belongs to the Special Issue Anti-Aging Activity of Food Components and Its Molecular Basis)
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