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Boost Brain Power with the Right Nutrition: Focus on Early Life

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: closed (25 March 2025) | Viewed by 1464

Special Issue Editor


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Guest Editor
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China
Interests: developmental origins of health and disease; women and children nutrition; nutition on bone health; phytochemicals on health; dairy and health; functional food
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on exploring the effects of different nutrients supplemented in early life on the growth, maturation, and functional development of the human central nervous system, especially the brain. It explores the effects of the different nutrients that are most suitable for brain potential development in terms of supplementation timing, dosage, and duration in early life, as well as their effects on the functional realization of different brain regions. Thus, we will evaluate the impacts of different dietary patterns and nutritional environments on brain development in populations of different ethnicities and genders and identify nutritional factors that are more suitable for human cognitive development. 

Prof. Dr. Yajun Xu
Guest Editor

Manuscript Submission Information

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Keywords

  • early-life nutrition
  • brain development
  • human central nervous system
  • cognitive
  • nutritional factors

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Published Papers (1 paper)

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Review

17 pages, 894 KiB  
Review
Vitamin B12 and Autism Spectrum Disorder: A Review of Current Evidence
by Mateusz Zwierz, Maria Suprunowicz, Katarzyna Mrozek, Jacek Pietruszkiewicz, Aleksandra Julia Oracz, Beata Konarzewska and Napoleon Waszkiewicz
Nutrients 2025, 17(7), 1220; https://doi.org/10.3390/nu17071220 - 31 Mar 2025
Viewed by 1183
Abstract
Vitamin B12 (cobalamin) plays a crucial role in neurodevelopment, particularly during pregnancy and early childhood. It is essential for DNA synthesis, red blood cell formation, and nervous system function. Maternal B12 levels are particularly important, as they influence fetal brain development. Inadequate maternal [...] Read more.
Vitamin B12 (cobalamin) plays a crucial role in neurodevelopment, particularly during pregnancy and early childhood. It is essential for DNA synthesis, red blood cell formation, and nervous system function. Maternal B12 levels are particularly important, as they influence fetal brain development. Inadequate maternal intake during pregnancy may lead to altered neurodevelopmental trajectories and increase the risk of ASD. Postnatally, insufficient dietary cobalamin in infants and young children could further contribute to cognitive and behavioral impairments. One potential mechanism linking low B12 levels to ASD involves its role in the gut microbiota balance. Dysbiosis, commonly observed in individuals with ASD, is associated with increased gut permeability, low-grade inflammation, and disruptions in the gut–brain axis, all of which may contribute to ASD symptoms. Additionally, B12 is essential for neurotransmitter metabolism, particularly in the synthesis of serotonin and dopamine, which regulate mood, cognition, and behavior. Cobalamin also plays a key role in neuronal myelination, which ensures efficient signal transmission in the nervous system. Disruptions in these processes could underlie some of the cognitive and behavioral features associated with ASD. Despite growing evidence, the link between B12 and ASD remains inconclusive due to inconsistent findings across studies. Research suggests that B12 levels may serve as a potential biomarker for disease progression and treatment response. However, many studies rely on single-time-point measurements, failing to account for individual variability, genetic predispositions, dietary intake, and environmental factors, all of which can influence B12 levels and ASD risk. Further longitudinal studies are needed to clarify this relationship. Full article
(This article belongs to the Special Issue Boost Brain Power with the Right Nutrition: Focus on Early Life)
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