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Exercise, Diet and Bone Health in Youth

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Sports Nutrition".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 5456

Special Issue Editors


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Guest Editor
1. Paediatrics, School of Medicine, The University of Western Australia, Perth, WA, Australia
2. Exercise Medicine Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
3. Institute for Health Research, The University of Notre Dame Australia, Fremantle, WA, Australia
4. Western Australian Bone Research Collaboration, Perth, WA, Australia
5. Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, WA, Australia
Interests: paediatric medicine; bone and mineral metabolism; exercise and bone health

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Guest Editor
1. Institute for Health Research, The University of Notre Dame Australia, Fremantle, WA, Australia
2. School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
3. Western Australian Bone Research Collaboration, Perth, WA, Australia
Interests: child and adolescent health; with a particular emphasis on movement disorders, bone health, education and obesity

Special Issue Information

Dear Colleagues,

In 2006, it was estimated that worldwide osteoporosis caused more than 8.9 million fractures annually, resulting in one osteoporosis-related fracture every 3 seconds. The global age-standardised rates of incidence, prevalence, and years lived with disability (YLD) for fractures decreased slightly from 1990 to 2019, but the absolute counts increased substantially with increased rates of fractures with age. Osteoporosis Australia predicted that, by 2022, 66% of Australians over 50 years of age will have osteoporosis or osteopenia with an increase in related minimal trauma fractures. Concerningly, data from Western Australia demonstrated that increased fracture rates starting from childhood and adolescence. This information raises concerns that the increased risk for adult osteoporosis might start early in life.

Therefore, strategies to prevent osteoporosis highlight the importance of maximum peak bone mass accrual during childhood and adolescence. Genetic predisposition determines up to 80% of peak bone mass; the remaining 20% are modulated by environmental factors and sex hormone levels during puberty. Negatively impacting factors are suboptimal diet, vitamin D deficiency and decreased physical activity levels, increasing an individual’s risk of developing osteoporosis later in life. Hence, optimising adolescent bone mass accrual by addressing levels of physical activity, diet, and vitamin D status may be important modifiable factors to preventing fractures and osteoporosis. Robust measures and methods are needed to monitor those parameters.

However, it appears that for children and adolescents there is a lack of detailed information on fracture incidence and characteristics of bone loading physical activity that impact on bone in humans, such as mode, frequency, intensity, and duration. These can be assessed using modalities, such as actigraphy or force plates assisted by questionnaires. Most information on how to optimize diet to support bone health in youth is not specific, analysis is mainly based on using questionnaires.  Methods to characterize bone health include biochemical analyses, as well as measures of bone mass, -density, -structure, and -strength on dual X-ray absorptiometry (DXA), and/or peripheral quantitative computer tomography (pQCT). 

For this Special Issue we invite authors to submit work to address this gap in information in the field of diet, exercise, and bone health in children and adolescents. Specific areas of interest include bone loading exercise modalities, impact of dietary factors on bone health, and methods to characterize bone health in this age group.   

This Special Issue of Nutrients entitled “Exercise, Diet and Bone Health in Youth” welcomes original research and reviews of the literature concerning this important topic.

Dr. Aris Siafarikas
Dr. Paola Chivers
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoporosis
  • youth
  • bone health
  • prevention
  • fractures
  • bone mass accrual
  • targeted exercise
  • bone loading
  • vitamin D
  • calcium

Published Papers (2 papers)

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Review

25 pages, 983 KiB  
Review
Prenatal and Neonatal Bone Health: Updated Review on Early Identification of Newborns at High Risk for Osteopenia
by Serafina Perrone, Chiara Caporilli, Federica Grassi, Mandy Ferrocino, Eleonora Biagi, Valentina Dell’Orto, Virginia Beretta, Chiara Petrolini, Lucia Gambini, Maria Elisabeth Street, Andrea Dall’Asta, Tullio Ghi and Susanna Esposito
Nutrients 2023, 15(16), 3515; https://doi.org/10.3390/nu15163515 - 9 Aug 2023
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Abstract
Bone health starts with maternal health and nutrition, which influences bone mass and density already in utero. The mechanisms underlying the effect of the intrauterine environment on bone health are partly unknown but certainly include the ‘foetal programming’ of oxidative stress and endocrine [...] Read more.
Bone health starts with maternal health and nutrition, which influences bone mass and density already in utero. The mechanisms underlying the effect of the intrauterine environment on bone health are partly unknown but certainly include the ‘foetal programming’ of oxidative stress and endocrine systems, which influence later skeletal growth and development. With this narrative review, we describe the current evidence for identifying patients with risk factors for developing osteopenia, today’s management of these populations, and screening and prevention programs based on gestational age, weight, and morbidity. Challenges for bone health prevention include the need for new technologies that are specific and applicable to pregnant women, the foetus, and, later, the newborn. Radiofrequency ultrasound spectrometry (REMS) has proven to be a useful tool in the assessment of bone mineral density (BMD) in pregnant women. Few studies have reported that transmission ultrasound can also be used to assess BMD in newborns. The advantages of this technology in the foetus and newborn are the absence of ionising radiation, ease of use, and, above all, the possibility of performing longitudinal studies from intrauterine to extrauterine life. The use of these technologies already in the intrauterine period could help prevent associated diseases, such as osteoporosis and osteopenia, which are characterised by a reduction in bone mass and degeneration of bone structure and lead to an increased risk of fractures in adulthood with considerable social repercussions for the related direct and indirect costs. Full article
(This article belongs to the Special Issue Exercise, Diet and Bone Health in Youth)
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37 pages, 7476 KiB  
Review
The Benefits to Bone Health in Children and Pre-School Children with Additional Exercise Interventions: A Systematic Review and Meta-Analysis
by Callum McCaskie, Aris Siafarikas, Jodie Cochrane Wilkie, Vanessa Sutton, Paola Chivers, Nicolas H. Hart and Myles C. Murphy
Nutrients 2023, 15(1), 127; https://doi.org/10.3390/nu15010127 - 27 Dec 2022
Cited by 3 | Viewed by 2780
Abstract
Objective: Determine if exercise interventions, beyond what is already provided to children and preschool children, improve bone health and reduce fracture incidence. Design: Systematic review and meta-analysis reported using the PRISMA guidelines. Certainty of evidence was assessed using GRADE recommendations. Data sources: Five [...] Read more.
Objective: Determine if exercise interventions, beyond what is already provided to children and preschool children, improve bone health and reduce fracture incidence. Design: Systematic review and meta-analysis reported using the PRISMA guidelines. Certainty of evidence was assessed using GRADE recommendations. Data sources: Five electronic databases were searched for records: PUBMED; CINAHL; CENTRAL; SPORTDiscus; Web of Science. Eligibility criteria for selecting studies: Randomised, quasi-randomised and non-randomised controlled trials (including cluster-randomised) assessing the impact of additional exercise interventions (e.g., increased physical education classes or specific jumping programs) on bone health in children (6–12 years) and pre-school children (2–5 years) without dietary intervention. Results: Thirty-one records representing 16 distinct clinical trials were included. Dual-energy X-ray Absorptiometry (DXA) and/or peripheral Quantitative Computed Tomography (pQCT) were used to quantify bone health. Increased femoral neck bone mineral content in children with additional exercise interventions (n = 790, SMD = 0.55, 95% CI = 0.01 to 1.09) was reported, however this was not significant following sensitivity analysis. Other DXA and pQCT measures, as well as fracture incidence, did not appear to significantly differ over time between intervention and control groups. No studies reported adverse events. Studies failed to report all domains within the TIDieR checklist. All studies were at high risk of bias using the Cochrane RoB Tool 2.0. The certainty of the evidence was very low. Conclusions: The addition of exercise interventions, beyond what is provided to children, does not appear to improve DXA and pQCT measures of bone health. The effect of additional exercise interventions on bone health in pre-school children is largely unknown. Future trials should ensure adherence is clearly reported and controlled for within analysis as well as including reports of adverse events (e.g., apophysitis) that occur due to increased exercise interventions. Full article
(This article belongs to the Special Issue Exercise, Diet and Bone Health in Youth)
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