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Application of New Metabolomics Approaches in Studying the Nutrition-Microbiome Reciprocal Interaction

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 193

Special Issue Editor


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Guest Editor
Centre de Recherche, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada
Interests: nutrition; lipid metabolism; vitamin D

Special Issue Information

Dear Colleagues,

It has been long accepted that the onset of disorders is the result of an interaction between a genetic predisposition and the environment, encompassing dietary regimen and lifestyle. However, the underlying mechanisms are still subjects of intense research. In more recent years, there has been mounting evidence pointing to a major role of the gut microbiota and its reciprocal relationship with macro- and micronutrients, in the modulation of diseases such as obesity, metabolic dysfunction-associated steatohepatitis, and vasculopathies. With the above paradigm in mind, innovative and constantly evolving technologies in the fields of genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics have the potential of uncovering complex interactions between host, nutrients, and microbiota. The information collected in this Special Issue, when applied, should contribute to the improvement of dietary protocols both as preventive and curative measures.

Prof. Dr. Edgard Delvin
Guest Editor

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Keywords

  • genomics
  • metabolomics
  • gut microbiome
  • nutrigenomics
  • metabolic diseases
  • metabolic networks

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Published Papers (1 paper)

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Research

10 pages, 546 KB  
Article
Body Composition, Microbiome and Physical Activity in Workers Under Intermittent Hypobaric Hypoxia
by Jorge Torres-Mejías, Karem Arriaza, Francisco Mena, Evangelina Rivarola, Patricio Paredes, Husam Ahmad, Iván López, Daniel Soza, José Luis Pino-Villalón, Miguel Ángel López-Espinoza, Samuel Duran-Agüero and Eugenio Merellano-Navarro
Nutrients 2025, 17(24), 3919; https://doi.org/10.3390/nu17243919 - 15 Dec 2025
Abstract
Background/Objectives: Intermittent hypobaric hypoxia (IHH) induces various physiological and metabolic adaptations. This study aimed to investigate the effects of a seven-day IHH exposure on nutritional status, body composition, gut microbiota, movement intensity, and energy expenditure in 10 workers. Methods: A pre–post comparative [...] Read more.
Background/Objectives: Intermittent hypobaric hypoxia (IHH) induces various physiological and metabolic adaptations. This study aimed to investigate the effects of a seven-day IHH exposure on nutritional status, body composition, gut microbiota, movement intensity, and energy expenditure in 10 workers. Methods: A pre–post comparative design was employed, with measurements taken at the beginning and end of the exposure period. Nutritional status, body composition, and phase angle (PhA) were assessed via bioelectrical impedance analysis (BIA). Gut microbiota composition was analyzed through fecal DNA extraction and qPCR for specific bacterial families. Movement intensity and energy expenditure were monitored using accelerometry. An initial statistical analysis was performed, which included paired t-tests and Wilcoxon signed-rank tests. Results: A significant increase in PhA (mean difference: 0.40; p = 0.0053 for t-test, p = 0.0136 for Wilcoxon) and a significant decrease in BMI (mean difference: −0.38; p = 0.0311 for t-test, p = 0.0546 for Wilcoxon). Conclusions: While the original paper reported no significant changes in nutritional status or body composition, our re-analysis suggests a significant change in BMI. The original paper also reported significant changes in specific gut bacterial families (butyrate-producing bacteria, p = 0.037; Lactobacillus species, p = 0.006). Physical activity levels remained consistently low. Full article
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