Gut-Targeted Biotherapies in Digestive and Metabolic Diseases
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics, Probiotics and Postbiotics".
Deadline for manuscript submissions: 15 November 2026 | Viewed by 258
Editor
Interests: gut health; gut microbiome; obesity; nutrition; metabolic disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The gut microbiota serves as a central hub linking digestive health to systemic metabolism. This special issue explores how microbiota-modulating interventions—probiotics, prebiotics, postbiotics, paraprobiotics, and synbiotics address the interconnected pathophysiology of digestive and metabolic disorders.
Probiotics and prebiotics reshape microbial composition and enhance short-chain fatty acid production, whilst postbiotics deliver bioactive metabolites without live organisms. Paraprobiotics provide stable, immunomodulatory alternatives, and synbiotics capitalise on synergistic interactions to optimise outcomes across disease domains.
These interventions strengthen intestinal barrier integrity, reduce systemic inflammation, modulate metabolic endotoxaemia, and promote metabolic homeostasis. This collection will synthesise evidence across digestive conditions (e.g. inflammatory bowel disease, irritable bowel syndrome, functional disorders), and metabolic diseases (e.g. obesity, type 2 diabetes, and metabolic-associated fatty liver disease (MAFLD)).
Emerging research reveals remarkable overlap: barrier dysfunction and dysbiosis underpin both intestinal inflammation and insulin resistance, whilst dysbiotic metabolites drive cardiometabolic risk. This special issue will integrate contemporary knowledge on microbiota-targeted therapeutics, explore cross-disease mechanisms, and identify precision approaches for managing the digestive-metabolic continuum.
Dr. Leni Rose Rivera
Guest Editor
Manuscript Submission Information
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Keywords
- probiotics
- prebiotics
- postbiotics
- paraprobiotics
- synbiotics
- gut microbiota
- digestive diseases
- metabolic diseases
- intestinal health
- microbiome
- gastrointestinal disorders
- gut barrier
- dysbiosis
- intestinal inflammation
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