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Precision Nutrition: A Personalised Approach to Health and Age Management

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".

Deadline for manuscript submissions: 25 April 2026 | Viewed by 1272

Special Issue Editors


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Guest Editor
Department of General Medicine, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania
Interests: genetic testing; epigenetic biomarkers; age management; gerontology; anti-ageing; healthcare; clinical nutrition; nutrigenomics; nutrigenetics; genetic polymorphism; reverse aging; slow aging
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Guest Editor
NutriSciLab—Nutrition & Nutraceuticals Research Lab, Clinical Laboratory, Nutrition and Food Safety Department, Faculty of Pharmacy, The University of Medicine and Pharmacy “Carol Davila”, 020956 Bucharest, Romania
Interests: nutritional evaluation; nutritional biomarkers; practical nutrition; metabolic disease; diabetes
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
National Institute of Gerontology and Geriatrics, Bucharest, Romania
Interests: older adults quality of life; elderly patients; geriatrics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The basis of precision nutrition and personalised nutrition is a medical rigour grade in nutritional evaluation and pharmacologically accurate intervention based on precise biochemical pathway modulation.

The significance of a detailed nutritional evaluation cannot be overstated. By analysing an individual's dietary habits, nutrient intake, and metabolic health markers, healthcare professionals can identify nutritional deficiencies, intolerances, and areas for improvement. This personalised analysis is the foundation for developing tailored nutritional plans that cater to the unique needs of each individual, ensuring that they receive the optimal balance of vitamins, minerals, and other essential nutrients.

Precision nutrition takes the concept of personalised dietary planning to the next level. By utilising advanced technologies such as genetic testing, microbiome analysis, and metabolic profiling, precision nutrition provides an in-depth understanding of an individual's unique physiological and metabolic characteristics. This approach allows for the creation of highly customised nutrition strategies that not only aim to improve overall health, but also prevent and manage chronic diseases more effectively.

The integration of precision nutrition into healthcare practices represents a significant shift towards a more proactive and preventive approach to health management. It acknowledges the complex interplay between genetics, environment, and lifestyle factors in determining an individual's health status and nutritional needs. By focusing on the individual rather than a one-size-fits-all guideline, precision nutrition offers a promising path to achieving optimal health outcomes.

Moreover, the importance of practical teaching methods in the field of nutrition cannot be overstressed. Workshops and hands-on training sessions, such as those provided by “NutriSciLab”, the nutrition research lab of Carol Davila” University of Medicine and Pharmacy, play a vital role in bridging the gap between theoretical knowledge and its real-world application. These practical experiences enable learners to acquire the skills necessary for conducting thorough nutritional assessments, devising customised nutrition plans, and understanding the complex interactions between food, gut microbiota, and overall health.

Such workshops not only enhance the learning experience, but also prepare aspiring nutritionists and dietitians for the challenges and nuances of personalised nutrition counselling.

By embracing these cutting-edge practices, individuals can take control of their health journey, making informed decisions that cater to their unique nutritional needs and health goals. As research continues to unfold, the potential for further innovations in this space holds the promise of even more effective health and nutrition strategies tailored to the individual, heralding a new era of personalised healthcare.

In this Special Issue, we welcome the submission of theoretical and experimental contributions in the form of full-length original research articles, literature reviews, and short communications.

We welcome the medical approach toward nutrition as a guide and foundation for all healthcare professionals involved in nutritional sciences. This Special Issue aims to collect scientific data regarding the following topics:

  • Geriatry;
  • Nutrigenetics;
  • Nutrigenomics;
  • Functional genomics;
  • SNPs;
  • Metabolomics;
  • Epigenetics and epigenomics;
  • OMICs age-management interventions;
  • Child nutrition;
  • Young adult nutrition;
  • Mature adult nutrition;
  • Senescent nutrition;
  • Nutritional senolytics;
  • Menopause andropause;
  • Gene–diet interactions;
  • Personalised nutrition;
  • Nutritional endocrine/hormonal modulation;
  • Microbiota and microbiomics;
  • Dietary patterns;
  • Nutritional metabolic modulation;
  • Nutritional homeostasis;
  • Metabolic energetic homeostasis;
  • Mitochondrial homeostasis;
  • Nutritional biomarkers;
  • Precise nutritional evaluations;
  • Biomarkers;
  • Circulating RNAs;
  • Genetics.

Dr. Ovidiu Penes
Dr. Anca Lucia Pop
Prof. Dr. Gabriel Ioan Prada
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • age-management interventions
  • precision nutrition
  • nutritional biomarkers
  • menopause andropause
  • gene–diet interactions
  • metabolic disease
  • nutritional evaluation
  • oral and gastrointestinal microbiota
  • food safety
  • fighting hunger
  • nutritional professionals
  • dietetics
  • food supplements
  • functional foods
  • dietary patterns
  • nutritional teaching
  • nutrition training
  • nutrition hands-on approaches

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Published Papers (1 paper)

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Research

22 pages, 1822 KB  
Article
Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial
by María P. Jarrín-Orozco, María Romo-Vaquero, Concepción Carrascosa, Miriam Pertegal, José Berná, Julio Puigcerver, Adrián Saura-Sanmartín, Isabel Espinosa-Salinas, María García-Nicolás, María Á. Ávila-Gálvez and Juan C. Espín
Nutrients 2025, 17(22), 3572; https://doi.org/10.3390/nu17223572 - 15 Nov 2025
Viewed by 617
Abstract
Background/Objectives: Interindividual variability in polyphenol metabolism may help explain the inconsistent effects of polyphenol intake on health outcomes. This study compared, for the first time, (i) polyphenol-related gut microbiota metabotypes (urolithins: UM0, UMA, UMB; equol: EP, ENP; lunularin: LP, LNP) and their [...] Read more.
Background/Objectives: Interindividual variability in polyphenol metabolism may help explain the inconsistent effects of polyphenol intake on health outcomes. This study compared, for the first time, (i) polyphenol-related gut microbiota metabotypes (urolithins: UM0, UMA, UMB; equol: EP, ENP; lunularin: LP, LNP) and their clusters (MCs) in non-medicated premenopausal (Pre-M) and postmenopausal (Post-M) women and (ii) the impact of an 8-week intake of a polyphenol-rich plant extract mixture (PPs) on the quality of life (QoL) of Post-M. Methods: Polyphenol metabotypes were determined in urine via UPLC-QTOF-MS after a 3-day intake of PPs containing resveratrol, pomegranate (ellagitannins and ellagic acid), and red clover (isoflavones) in Pre-M (n = 120) and Post-M (n = 90) women. QoL was assessed with the short-form Cervantes Scale in a randomized, placebo-controlled crossover trial (8-week PPs vs. placebo), completed by 78 Post-M participants. Results: At baseline, Pre-M and Post-M women showed only minor differences in metabotype and MC distributions linked to menopausal status. MC3 (UMA+EP+LP) predominated in Pre-M, while MC7 (UMA+EP+LNP) was most frequent in Post-M. PPs intake in Post-M women led to modest shifts in metabotype and MC distributions toward Pre-M patterns. Quantitative metabolite production was comparable between groups, except for equol, which showed a median 2.8-fold increase after PPs intake in EP Post-M women. Clinically meaningful improvements (score reduction ≥ 6.7 points) in QoL were observed in the Psychic domain in EP women (28%, p = 0.039) and in the Menopause and Health domain, specifically in EP (24.1%, p = 0.004), MC3 (22.5%, p = 0.043), and MC4 (UMB+EP+LP; 41.3%, p = 0.022), were mainly driven by a reduction in hot flashes (p = 0.001). Conclusions: These findings support metabotyping as a tool to guide targeted dietary strategies and enhance QoL through precision health in Post-M women. Full article
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