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Nutrients
Special Issues
Nutrigenetic, Nutrigenomic & Nutriepigenetic Approaches in Age Management Interventions
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Nutrigenetic, Nutrigenomic & Nutriepigenetic Approaches in Age Management Interventions

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 3537

Special Issue Editors

Dr. Anca Lucia Pop

E-Mail Website1 Website2
Guest Editor
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
Interests: nutritional evaluation; nutritional biomarkers; practical nutrition; metabolic disease; diabetes
Special Issues, Collections and Topics in MDPI journals
Dr. Ovidiu Penes

E-Mail Website
Guest Editor
Department of Genetics, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania
Interests: genetic testing; epigenetic biomarkers; age management; gerontology; anti-aging; healthcare; clinical nutrition; nutrigenomics; nutrigenetics; genetic polymorphism; reverse aging; slow aging

Special Issue Information

Dear Colleagues,

The basis of precision nutrition and personalized nutrition is a medical rigor grade in nutritional evaluation and pharmacologically accurate intervention based on precise biochemical pathway modulation.

We welcome the medical approach in nutrition as a guide and foundation for all healthcare professionals involved in nutritional sciences. This Special Issue should collect scientific data regarding:

  • Nutrigenetics;
  • Nutrigenomics;
  • Functional genomics;
  • SNP’s;
  • Metabolomics;
  • Microbiota and microbiomics;
  • Epigenetics and epigenomics;
  • OMICs age management interventions;
  • Child nutrition;
  • Young adult nutrition;
  • Mature adult nutrition;
  • Senescent nutrition;
  • Nutritional senolytics;
  • Menopause andropause;  
  • Gene–diet interactions;  
  • Personalized nutrition;  
  • Nutritional endocrine/hormonal modulation;  
  • Dietary patterns;  
  • Nutritional metabolic modulation;  
  • Nutritional homeostasis;  
  • Metabolic energetic homeostasis;  
  • Mitochondrial homeostasis;  
  • Nutritional miomarkers;
  • Nutritional precise evaluation;
  • Nutritional anthropometry;
  • Biomarkers;
  • Circulating RNAs;  
  • Food technology;  
  • Sustainability;  
  • Genetics.

Dr. Anca Lucia Pop
Dr. Ovidiu Penes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrigenetics
  • nutrigenomics
  • functional genomics
  • SNP's
  • metabolomics
  • microbiota and microbiomics
  • epigenetics and epigenomics
  • OMICs age management interventions
  • child nutrition
  • young adult nutrition
  • mature adult nutrition
  • senescent nutrition
  • nutritional senolytics
  • menopause andropause
  • gene–diet interactions
  • personalized nutrition
  • nutritional endocrine/hormonal modulation
  • dietary patterns
  • nutritional Metabolic modulation
  • nutritional homeostasis
  • metabolic energetic homeostasis
  • mitochondrial homeostasis
  • nutritional Biomarkers
  • nutritional precise evaluation
  • nutritional anthropometry
  • biomarkers
  • circulating RNAs
  • sustainability
  • genetics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

13 pages, 1220 KiB  
Article
The Importance of Nutriepigenetics in Older Adults with Inflammatory Bowel Disease
by Ana-Gabriela Prada, Costina Daniela Gîță, Sandra Monica Gîdei, Doina Istratescu, Tudor Stroie, Sorina Maria Aurelian, Gabriel Ioan Prada, Ovidiu Nicolae Penes, Anca Lucia Pop and Mihai Mircea Diculescu
Nutrients 2025, 17(4), 620; https://doi.org/10.3390/nu17040620 - 9 Feb 2025
Cited by 1 | Viewed by 1013
Abstract
Background: Nutriepigenetics, the study of nutritional effects on gene expression, offers new insights into the clinical variability and relapse frequency of inflammatory bowel disease (IBD). As older adult populations are frequently unrepresented in the literature regarding their nutrition’s influence on their gene expression, [...] Read more.
Background: Nutriepigenetics, the study of nutritional effects on gene expression, offers new insights into the clinical variability and relapse frequency of inflammatory bowel disease (IBD). As older adult populations are frequently unrepresented in the literature regarding their nutrition’s influence on their gene expression, we considered that studying this aspect would shed light on this population group. Materials and Methods: We conducted a prospective observational study on 60 IBD patients, categorized by age, residence, and nutrition access. Patients were grouped according to age groups (“young”-old—65–74 years old and old-old—75–86 years old), gender, IBD type, organic diet preference, Simple Clinical Colitis Activity Index (SCCAI), and Harvey-Bradshaw Index (HBI) at diagnosis and after diet change. All patients were followed up at the Fundeni Clinical Institute in Bucharest, Romania, and received personalized dietary recommendations, in accordance with the European guidelines. Results: Our findings revealed that a diet that was predominantly organic had a positive impact on decreasing the number of relapse episodes, irrespective of IBD type. Predominant diets, rich in dairy and saturated fats, mostly from non-organic sources, exacerbated inflammation and increased the frequencies of relapses. Conclusions: Older adult patients who adopted a predominantly organic diet had a reduction in frequency of relapse episodes, thus proving that diet is an important part of the treatment regimen of this population. Full article
(This article belongs to the Special Issue Nutrigenetic, Nutrigenomic & Nutriepigenetic Approaches in Age Management Interventions)
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12 pages, 1393 KiB  
Article
Identification of Sweetness Preference-Related Single-Nucleotide Polymorphisms for Polygenic Risk Scores Associated with Obesity
by Ji Hyun Bae and Hyunju Kang
Nutrients 2024, 16(17), 2972; https://doi.org/10.3390/nu16172972 - 3 Sep 2024
Cited by 2 | Viewed by 1402
Abstract
Our study aimed to identify sweetness preference-associated single-nucleotide polymorphisms (SNPs), characterize the related genetic loci, and develop SNP-based polygenic risk scores (PRS) to analyze their associations with obesity. For genotyping, we utilized a pooled genome-wide association study (GWAS) dataset of 18,499 females and [...] Read more.
Our study aimed to identify sweetness preference-associated single-nucleotide polymorphisms (SNPs), characterize the related genetic loci, and develop SNP-based polygenic risk scores (PRS) to analyze their associations with obesity. For genotyping, we utilized a pooled genome-wide association study (GWAS) dataset of 18,499 females and 10,878 males. We conducted genome-wide association analyses, functional annotation, and employed the weighted method to calculate the levels of PRS from 677 sweetness preference-related SNPs. We used Cox proportional hazards modeling with time-varying covariates to estimate age-adjusted and multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for obesity incidence. We also tested the correlation between PRS and environmental factors, including smoking and dietary components, on obesity. Our results showed that in males, the TT genotype of rs4861982 significantly increased obesity risk compared to the GG genotype in the Health Professionals Follow-up Study (HPFS) cohort (HR = 1.565; 95% CI, 1.122–2.184; p = 0.008) and in the pooled analysis (HR = 1.259; 95% CI, 1.030–1.540; p = 0.025). Protein tyrosine phosphatase receptor type O (PTPRO) was identified as strongly associated with sweetness preference, indicating a positive correlation between sweetness preference and obesity risk. Moreover, each 10 pack-year increment in smoking was significantly associated with an increased risk of obesity in the HPFS cohort (HR = 1.024; 95% CI, 1.000–1.048) in males but not in females. In conclusion, significant associations between rs4861982, sweetness preference, and obesity were identified, particularly among males, where environmental factors like smoking are also correlated with obesity risk. Full article
(This article belongs to the Special Issue Nutrigenetic, Nutrigenomic & Nutriepigenetic Approaches in Age Management Interventions)
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