Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.2
4.8
Journals
Nutrients
Special Issues
Prevention and Treatment of Liver Diseases by Dietary Habits and...
nutrients-logo
Submit to Special Issue Submit Abstract to Special Issue Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Prevention and Treatment of Liver Diseases by Dietary Habits and Lifestyle

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 15 December 2024 | Viewed by 4765

Special Issue Editors

Dr. Marica Cariello

E-Mail Website
Guest Editor
Clinica Medica Cesare Frugoni, Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Interests: nutrients; nuclear receptors; gut–liver axis; tumorigenesis; cholesterol and lipid metabolism
Special Issues, Collections and Topics in MDPI journals
Dr. Raffaella Maria Gadaleta

E-Mail Website
Guest Editor
Clinica Medica Cesare Frugoni, Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Interests: nutrition; nutrigenomics; pathophysiology of the gut–liver axis; gastrointestinal; Mediterranean diet
Dr. Carlo De Matteis

E-Mail Website
Guest Editor Assistant
Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare 11, 70124 Bari, Italy
Interests: liver fibrosis; non-alcoholic steatohepatitis; non-alcoholic fatty liver disease; non-invasive liver fibrosis scores

Special Issue Information

Dear Colleagues,

Liver diseases are often associated with metabolic conditions, such as metabolic dysfunction-associated steatotic liver disease (MASLD). The definition of MASLD has been rebranded, shifting the definition of non-alcoholic fatty liver disease (NAFLD), and is now more representative of the clinical and metabolic heterogeneity characterizing patients presenting with the accumulation of excess fat in the liver in the presence of other cardiometabolic risk factors. Dietary habits and lifestyle have a critical impact on the pathogenesis of liver diseases. Evidence shows that a balanced diet together with moderate and regular exercise as adjuvant therapeutic strategies in these patients are successfully improving steatosis, inflammation, hepatocyte ballooning, and fibrosis, which can even lead to the development of hepatocellular carcinoma. The clinical and metabolic benefits of lifestyle management are mainly achieved via mechanisms encompassing nutrigenomics, gut microbiota modulation, improvement in mitochondrial dysfunctions and oxidative stress, and the inhibition of inflammatory pathways.

In this Special Issue, we aim to summarize the main evidence on dietary habits and lifestyle in the prevention and treatment of liver diseases, and we welcome reviews, perspectives, short communications, and original research to reinforce the critical importance of lifestyle intervention and comprehensive management in addressing this growing global health concern.

Dr. Marica Cariello
Dr. Raffaella Maria Gadaleta
Guest Editors

Carlo De Matteis
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver diseases
  • MASLD
  • lifestyle
  • dietary habits
  • nutrition

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

11 pages, 840 KiB  
Article
Extra Virgin Olive Oil Reduces the Risk of Non-Alcoholic Fatty Liver Disease in Females but Not in Males: Results from the NUTRIHEP Cohort
by Rossella Donghia, Rossella Tatoli, Angelo Campanella, Giuseppe Losurdo, Alfredo Di Leo, Giovanni De Pergola, Caterina Bonfiglio and Gianluigi Giannelli
Nutrients 2024, 16(19), 3234; https://doi.org/10.3390/nu16193234 - 24 Sep 2024
Viewed by 1353
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. One way to resolve this reversible condition is by making dietary changes. Extra virgin olive oil (EVOO) is often associated with an improvement in this disease. The aim of [...] Read more.
Background: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. One way to resolve this reversible condition is by making dietary changes. Extra virgin olive oil (EVOO) is often associated with an improvement in this disease. The aim of this study was to explore the protective role of EVOO on NAFLD conditions, stratified by gender. Methods: The study cohort included 1426 participants assessed in the second recall of the NUTRIHEP cohort (2014–2018), subdivided by gender and dividing the EVOO intake into quartiles of daily gram intake. Results: The results indicated a protective role of the last quartile of EVOO only for female subjects, OR = 0.43, p = 0.02, 0.21 to 0.85 at 95% C.I., whereas in the male sub-cohort, the effect was not statistically significant. Conclusions: The protective role of EVOO is different between genders. This difference has not been explored in the literature, so we conclude that this is one of the few papers in the literature to evaluate a gender difference in the intestinal absorption of humans based on an epidemiological study. Full article
(This article belongs to the Special Issue Prevention and Treatment of Liver Diseases by Dietary Habits and Lifestyle)
►▼ Show Figures

Figure 1

13 pages, 2210 KiB  
Article
Reassessing the Impact of Coffee Consumption on Liver Disease: Insights from a Large-Scale Cohort Study with IPTW Adjustment
by Keungmo Yang, Young Chang, Soung Won Jeong, Jae Young Jang and Tom Ryu
Nutrients 2024, 16(13), 2020; https://doi.org/10.3390/nu16132020 - 26 Jun 2024
Viewed by 2547
Abstract
Coffee consumption is globally widespread and has become a lifestyle habit. This study investigated coffee consumption and liver-related survival in a large cohort of 455,870 individuals with UK biobank, categorized into without steatosis, metabolic dysfunction-associated steatotic liver disease (MASLD), and MASLD and increased [...] Read more.
Coffee consumption is globally widespread and has become a lifestyle habit. This study investigated coffee consumption and liver-related survival in a large cohort of 455,870 individuals with UK biobank, categorized into without steatosis, metabolic dysfunction-associated steatotic liver disease (MASLD), and MASLD and increased alcohol intake (MetALD). Inverse probability of treatment weighting (IPTW) adjusted for confounding variables was used, followed by Kaplan–Meier analysis. Moderate coffee consumption (1–2 cups per day) was associated with lower all-cause mortality across the entire cohort, without the steatosis, MASLD (p < 0.0001), and MetALD cohorts (p = 0.0047 for pre-IPTW, p = 0.027 for post-IPTW). Before IPTW adjustment, consuming one or more cups of coffee per day appeared to significantly reduce liver-related mortality in the overall (p = 0.015) and MASLD cohorts (p = 0.011). However, post-IPTW application, no significant differences in liver-related mortality were observed between the coffee intake groups (p = 0.778, 0.319, 0.564, 0.238 for each group). While increased coffee consumption initially seemed to reduce liver-related mortality, after IPTW adjustment, only all-cause mortality significantly decreased (p < 0.0001 and p = 0.027). These findings suggest that previous studies might have overestimated the favorable effect of coffee intake on chronic liver disease due to confounding factors. Full article
(This article belongs to the Special Issue Prevention and Treatment of Liver Diseases by Dietary Habits and Lifestyle)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

18 pages, 2313 KiB  
Review
Inappropriate Diet Exacerbates Metabolic Dysfunction-Associated Steatotic Liver Disease via Abdominal Obesity
by Minghui Xiang, Xiaoli Tian, Hui Wang, Ping Gan and Qian Zhang
Nutrients 2024, 16(23), 4208; https://doi.org/10.3390/nu16234208 - 5 Dec 2024
Viewed by 429
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a refined categorization of non-alcoholic fatty liver disease (NAFLD), highlighting the intricate relationship between hepatic steatosis and metabolic dysfunction. Abdominal obesity (AO), a key diagnostic criterion for metabolic dysfunction, predominantly results from inappropriate diet and unhealthy [...] Read more.
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a refined categorization of non-alcoholic fatty liver disease (NAFLD), highlighting the intricate relationship between hepatic steatosis and metabolic dysfunction. Abdominal obesity (AO), a key diagnostic criterion for metabolic dysfunction, predominantly results from inappropriate diet and unhealthy dietary habits. To comprehensively investigate which dietary factors contribute to MASLD through AO and to understand the underlying biological mechanisms, we initially conducted a systematic review of meta-analysis articles in the PubMed database from the past decade, summarizing dietary factors that affect AO. Subsequently, we conducted targeted searches in the PubMed database for these dietary factors and provided a narrative review of the mechanisms of how these dietary factors lead to AO and how AO exacerbates MASLD. A diet characterized by excessive intake of energy, carbohydrates, fructose, or ultra-processed foods (UPFs) is considered inappropriate. Inappropriate diet leads to the formation of MASLD and AO by enhancing pathways such as de novo lipid synthesis (DNL) in the liver, insulin resistance (IR), gut–liver dysfunction, and inflammation. Dietary interventions for inappropriate diets can effectively intervene in and improve MASLD and AO. The mechanism of inappropriate diet on abdominal fat deposition is through excessive energy or the activation of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) to increase endocortisol secretion. Then, the excessive accumulation of visceral fat facilitates a rapid and augmented flux of free fatty acids (FFAs) to the liver and initiates a series of deleterious effects, including oxidative stress (OS), endoplasmic reticulum stress (ERS), activation of protein kinase C (PKC) pathways, and inflammation. Additionally, FFAs may mediate excessive lipid deposition and hepatocellular damage through the action of hormones. These pathways to liver damage exacerbate MASLD and progression to metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis. Furthermore, investigating other potential mechanisms by which AO may influence MASLD could offer new recommendations for the treatment guidelines of MASLD. Full article
(This article belongs to the Special Issue Prevention and Treatment of Liver Diseases by Dietary Habits and Lifestyle)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop