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Effects of Maternal Nutrition and Lifestyle before and during Pregnancy on Short- and Long-Term Outcomes

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition in Women".

Deadline for manuscript submissions: closed (25 March 2025) | Viewed by 2030

Special Issue Editor


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Guest Editor
Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20157 Milan, Italy
Interests: maternal nutrition; fetal programming; maternal obesity; pregnancy pathologies; pregnancy; placenta; placental mitochondria; DOHaD

Special Issue Information

Dear Colleagues,

This Special Issue deals with the effects of maternal nutrition and lifestyle before and during pregnancy on short- and long-term outcomes, for both the mother and offspring.

Correct nutrition and a healthy lifestyle are fundamental elements for the successful outcome of a pregnancy.

Malnutrition, found both in conditions of undernutrition and overnutrition such as obesity, is expanding exponentially worldwide to near-epidemic proportions, representing a significant risk factor for gestational complications and impaired pregnancy outcomes. Additionally, other lifestyle factors, such as inadequate physical activity, stress and poor oral health, can affect the outcomes of a pregnancy. This has short- and long-term negative consequences for both mothers and newborns. The Developmental Origin of Health and Disease model underlines the strong impact that maternal nutritional status and lifestyle can have on the health of future generations, with important socio-economic consequences in all countries of the world.

The prevention of malnutrition and unhealthy behaviors, as well as understanding the mechanisms underlying their association with negative pregnancy outcomes, is therefore of extreme importance for global health and global socio-economic stability.

Among ongoing research, studies on placental alterations, maternal biomarkers and epigenetics are leading to a partial comprehension of the events that come into play in these conditions, which could provide interesting insights for future interventions. However, further investigations also including in vivo and in vitro studies and the use of models such as organoids are necessary.

In this Special Issue of Nutrients, we welcome original research articles, as well as review articles on the current state of research.

Dr. Chiara Mandò
Guest Editor

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Keywords

  • pregnancy
  • maternal nutrition and lifestyle
  • placenta
  • malnutrition
  • obesity
  • fetal metabolism
  • microbiota
  • gestational complications
  • pregnancy outcomes

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Published Papers (1 paper)

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Research

16 pages, 3021 KiB  
Article
From Mother to Child: Epigenetic Signatures of Hyperglycemia and Obesity during Pregnancy
by Marica Franzago, Paola Borrelli, Marta Di Nicola, Pierluigi Cavallo, Ebe D’Adamo, Luciano Di Tizio, Diego Gazzolo, Liborio Stuppia and Ester Vitacolonna
Nutrients 2024, 16(20), 3502; https://doi.org/10.3390/nu16203502 - 16 Oct 2024
Cited by 4 | Viewed by 1634
Abstract
Background: In utero exposure to maternal hyperglycemia and obesity can trigger detrimental effects in the newborn through epigenetic programming. We aimed to assess the DNA methylation levels in the promoters of MC4R and LPL genes from maternal blood, placenta, and buccal swab samples [...] Read more.
Background: In utero exposure to maternal hyperglycemia and obesity can trigger detrimental effects in the newborn through epigenetic programming. We aimed to assess the DNA methylation levels in the promoters of MC4R and LPL genes from maternal blood, placenta, and buccal swab samples collected in children born to mothers with and without obesity and Gestational Diabetes Mellitus (GDM). Methods: A total of 101 Caucasian mother–infant pairs were included in this study. Sociodemographic characteristics, clinical parameters, physical activity, and adherence to the Mediterranean diet were evaluated in the third trimester of pregnancy. Clinical parameters of the newborns were recorded at birth. Results: A negative relationship between MC4R DNA methylation on the fetal side of the GDM placenta and birth weight (r = −0.630, p = 0.011) of newborns was found. MC4R DNA methylation level was lower in newborns of GDM women (CpG1: 2.8% ± 3.0%, CpG2: 3.8% ± 3.3%) as compared to those of mothers without GDM (CpG1: 6.9% ± 6.2%, CpG2: 6.8% ± 5.6%; p < 0.001 and p = 0.0033, respectively), and it was negatively correlated with weight (r = −0.229; p = 0.035), head circumference (r = −0.236; p = 0.030), and length (r = −0.240; p = 0.027) at birth. LPL DNA methylation was higher on the fetal side of the placenta in obese patients as compared to normal-weight patients (66.0% ± 14.4% vs. 55.7% ± 15.2%, p = 0.037), and it was associated with maternal total cholesterol (r = 0.770, p = 0.015) and LDL-c (r = 0.783, p = 0.012). Conclusions: These results support the role of maternal MC4R and LPL methylation in fetal programming and in the future metabolic health of children. Full article
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