Maternal Diet, Epigenetic Mechanisms and Metabolic Programming
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".
Deadline for manuscript submissions: 25 December 2024 | Viewed by 7746
Special Issue Editors
2. Department of Child Health, University of Arizona, Phoenix, AZ 85721, USA
3. Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada
Interests: maternal nutrition; offspring; neurodevelopment; neurological diseases; stroke; vascular dementia; aging
Special Issue Information
Dear Colleagues,
The maternal environment influences embryonic and fetal development. Among environmental factors, nutrition is the most vital one that modulates the expression of genes involved in metabolic pathways and a variety of phenotypes associated with growth, development, and health. Maternal diet and nutritional factors affect various aspects of metabolic programming. These changes are induced in early life, and may alter the phenotype later in life, influencing the development of metabolic diseases and neurodevelopment. In particular, dietary imbalances during pregnancy may affect neurodevelopment during the sensitive period, thereby increasing the susceptibility of offspring to neurological diseases (e.g., stroke and vascular dementia).
Identification of dietary factors’ role in development, including methyl group donors (e.g., folate, choline) and bioactive compounds (e.g., polyphenols), is of great importance; however, insufficient knowledge exists in addressing how maternal diet influences epigenetic mechanisms during offspring development and how to prevent potential negative effects on later life.
In this Special Issue, original articles and reviews addressing the effects of maternal diet and nutrition on metabolic programming and potential mechanisms of maternal epigenetic regulation of gene expression that have persistent effects on offspring health and development are welcome.
I look forward to receiving your contributions.
Dr. Nafisa M. Jadavji
Dr. John Krzeczkowski
Guest Editors
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Keywords
- maternal diet
- epigenetic mechanisms
- metabolic programming
- offspring’s health
- folate
- neurological diseases
- neurodevelopmental disorders
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