Personalized Nutrition, Gut Microbiome, Metabolic Syndrome and Related Comorbidities
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 3828
Special Issue Editor
Interests: gut microbiome; bioactive compounds, nutrition; cardiometabolic health; metabolic disorders; microbiome-host interactions
Special Issue Information
Dear Colleagues,
Inter-individual variability in response to therapeutic interventions, whether nutritional or pharmacological, is a critical factor in determining health outcomes. This variability is especially pronounced in the context of metabolic syndrome (MetS), a complex and multifactorial condition characterized by a cluster of cardiovascular risk factors: central obesity, insulin resistance, hypertension, and dyslipidemia. The complexity of these interrelated factors makes the study of MetS challenging and proactive identification and intervention strategies are therefore required. The gut microbiome has been associated with the pathogenesis and development of MetS and related comorbidities, either as a causal agent or as a consequence of metabolic dysregulation, and its active role and impact on human health are well established. A particularly relevant aspect is the bidirectional interaction between dietary compounds and the gut microbiome, which can yield benefits for both the host and the microbiome itself, as seen with dietary bioactive compounds such as phenolic compounds, fiber, carotenoids and glucosinolates. Dietary interventions are essential in the prevention and management of MetS and its associated comorbidities, and the three-way interaction between the gut microbiome, diet, and health is crucial for advancing the treatment and management of MetS. By tailoring dietary strategies to the unique characteristics of each individual, personalized nutrition aims to optimize therapeutic outcomes and mitigate disease progression, providing a framework for developing targeted interventions that address the underlying mechanisms of MetS.
This Special Issue aims to advance the field by exploring cutting-edge research and advancements in personalized nutrition strategies that target the gut microbiome to prevent and manage MetS and its related comorbidities. We welcome the submission of manuscripts that present original research or comprehensive reviews, including systematic reviews and meta-analyses, that investigate the role of dietary interventions, nutrigenomics, and microbiome-targeted therapies in modulating metabolic health, especially in the context of MetS and its associated comorbidities. The scope of this Special Issue includes the effects of nutrients, dietary bioactive compounds, dietary patterns, and interventions involving probiotics, prebiotics or postbiotics, and it will focus on the mechanisms by which the gut microbiome mediates these effects, with attention to interindividual variability; this will enhance our understanding of their impact on metabolic health.
Dr. Adrián Cortés-Martín
Guest Editor
Manuscript Submission Information
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Keywords
- metabolic syndrome
- gut microbiome
- personalized nutrition
- precision nutrition
- gut microbiota
- non-communicable diseases
- diet
- health
- diabetes
- obesity
- dyslipidemia
- hypertension
- bioactive compounds
- nutrigenomics
- prebiotics
- probiotics
- postbiotics
- dietary intervention
- insulin resistance
- cardiovascular diseases
- metabolic health
- dietary fibres
- phenolic compounds
- chronic diseases
- microbiota-host interactions
- diet-microbiome interactions
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