The Quest for Human Health in the Genomic Era: Nutrigenomics Approaches to Natural Products

Dear Colleagues,

In the genomic era, nutrition is no longer seen merely as a source of energy but as a powerful tool in influencing human health. Nutrigenomics reveals how natural dietary compounds can modulate biological pathways and (epi)genetic mechanisms. This growing field highlights how natural dietary components may contribute to health promotion and disease prevention.

This Special Issue will focus on the role of phytocompounds and plant extracts enriched in specific bioactives, exploring their molecular mechanisms and nutrigenomic effects.

Particular attention will be given to bioactive molecules such as polyphenols, flavonoids, and plant extracts. These substances have demonstrated the ability to influence transcription factors, non-coding RNAs, and epigenetic markers, with implications for the prevention and management of chronic diseases. Moreover, many of these natural compounds exhibit protective effects against toxic xenobiotics commonly found in food and water, reducing their impact on cellular homeostasis and gene regulation.

We aim to highlight how these compounds influence key signaling pathways and epigenetic markers, offering new opportunities for personalized nutrition.

We welcome original research, reviews, and case studies that examine how natural products can be used as genomic modulators to promote human health in the context of diet-related chronic diseases, aging, metabolic dysfunction, and inflammation.

Dr. Flores Naselli
Dr. Ilenia Cruciata
Guest Editors

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