Special Issue "Calorie Restriction’s Effects on Health and Disease: From Basic Research to Human Health"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editor

Prof. Dr. Takuya Chiba
Guest Editor
Biomedical Gerontology Laboratory, Faculty of Human Sciences, Waseda University, Japan
Interests: biology of aging; longevity science; calorie restriction mimetics; food factor

Special Issue Information

Dear Colleagues,

Calorie restriction is one of the most viable interventions to help reduce morbidity from age-related diseases and to increase healthy lifespans and longevity. The term itself implies various forms of nutritional interventions, such as reducing total caloric intake, reducing macronutrients, and temporal limitation of food intake, in ways that include intermittent fasting and limiting eating periods. Recently, calorie restriction mimetics, which imitate the health benefits of calorie restriction without actual food intake restriction, have been attracting attention for use in nutritional interventions and drug development to support healthy lives.

In this Special Issue of Nutrients, we focus on the study of calorie restriction in basic research on animals, as well as clinical application in research that affects humans. Recent tools for high-throughput research instruments can investigate and determine critical signaling pathways and identify responsible molecules for the life-extending effects of calorie restriction. Potential candidates for calorie restriction mimetics are also extensively explored and verified through the use of cells, mice, and even humans. Additionally, we offer discussion on the immune system and inflammation concerning aging during calorie restriction.

This Special Issue is dedicated to increasing and renewing our knowledge of the effects of calorie restriction on age-related diseases and longevity-oriented guidelines. We expect that this issue will improve our understanding of recent advances in calorie restriction research for researchers from many fields of expertise. We welcome a variety of manuscript submissions, including original research, short reports, and reviews

Prof. Takuya Chiba
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Calorie restriction mimetics
  • Immunosenescence
  • Inflammaging
  • Inter-organ communication
  • Ketone body

Published Papers (1 paper)

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Open AccessReview
Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors?
Nutrients 2020, 12(7), 1959; https://doi.org/10.3390/nu12071959 - 30 Jun 2020
Calorie restriction (CR) has been shown to extend lifespan and retard aging-related functional decline in animals. Previously, we found that the anti-neoplastic and lifespan-extending effects of CR in mice are regulated by forkhead box O transcription factors (FoxO1 and FoxO3), located downstream of [...] Read more.
Calorie restriction (CR) has been shown to extend lifespan and retard aging-related functional decline in animals. Previously, we found that the anti-neoplastic and lifespan-extending effects of CR in mice are regulated by forkhead box O transcription factors (FoxO1 and FoxO3), located downstream of growth hormone (GH)–insulin-like growth factor (IGF)-1 signaling, in an isoform-specific manner. Inflammaging is a term coined to represent that persistent low-level of inflammation underlies the progression of aging and related diseases. Attenuation of inflammaging in the body may underlie the effects of CR. Recent studies have also identified cellular senescence and activation of the nucleotide-binding domain, leucine-rich-containing family, pyrin-domain-containing-3 (NLRP3) inflammasome as causative factors of inflammaging. In this paper, we reviewed the current knowledge of the molecular mechanisms linking the effects of CR with the formation of inflammasomes, particularly focusing on possible relations with FoxO3. Inflammation in the brain that affects adult neurogenesis and lifespan was also reviewed as evidence of inflammaging. A recent progress of microRNA research was described as regulatory circuits of initiation and propagation of inflammaging. Finally, we briefly introduced our preliminary results obtained from the mouse models, in which Foxo1 and Foxo3 genes were conditionally knocked out in the myeloid cell lineage. Full article
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