Special Issue "New Treatments for Anemia in Chronic Inflammatory Disorders"
Deadline for manuscript submissions: 15 September 2021.
Interests: infectious diseases; macrophage; immune response; cytokines; T lymphocytes; immunology; immunity; immune regulation; inflammation; autoimmunity
Chronic inflammatory disorders are associated with an increased risk of anemia. Cytokines released during cell-mediated immune responses are capable of inhibiting bone marrow hematopoiesis, e.g., the pro-inflammatory cytokines interferon gamma (IFN-γ) and tumor-necrosis factor-a (TNF-a) inhibit the growth of erythroid precursor cells in vitro. The mode of action of these cytokines is probably associated with their antiproliferative property.
The decrease of serum iron and increase of storage iron appear to be consequences of the defense strategy of macrophages. Decreased serum iron correlates with decreased hemoglobin concentrations. Thus, the development of anemia seems likely to result from the altered iron metabolism induced by stimulated macrophages.
In the course of anti-tumor immune response, IFN-γ induces the enzyme indoleamine 2,3-dioxygenase (IDO1) to degrade tryptophan. Inflammation-mediated tryptophan catabolism along the kynurenine pathway is related to fatigue and anemia, to depression and a decreased quality of life in patients.
This Special Issue of Nutrients is focusing on the association between nutrition and new treatments for anemia in chronic inflammatory disorders. Authors are invited to submit their work, including original research, reviews, meta-research, and opinion papers, showcasing important issues governing nutrition and new treatments for anemia in chronic inflammatory disorders, e.g., are there possibilities to interfere with iron or tryptophan metabolism or supplementation with anti-inflammatory or antioxidant supplements to combat anemia development.
Prof. Dietmar Fuchs
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Iron metabolism