New Treatments for Anemia in Chronic Inflammatory Disorders
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".
Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 8290
Special Issue Editor
Interests: neopterin; tryptophan; kynurenine; analytical chemistry; biomarkers; immunobiochemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic inflammatory disorders are associated with an increased risk of anemia. Cytokines released during cell-mediated immune responses are capable of inhibiting bone marrow hematopoiesis, e.g., the pro-inflammatory cytokines interferon gamma (IFN-γ) and tumor-necrosis factor-a (TNF-a) inhibit the growth of erythroid precursor cells in vitro. The mode of action of these cytokines is probably associated with their antiproliferative property.
The decrease of serum iron and increase of storage iron appear to be consequences of the defense strategy of macrophages. Decreased serum iron correlates with decreased hemoglobin concentrations. Thus, the development of anemia seems likely to result from the altered iron metabolism induced by stimulated macrophages.
In the course of anti-tumor immune response, IFN-γ induces the enzyme indoleamine 2,3-dioxygenase (IDO1) to degrade tryptophan. Inflammation-mediated tryptophan catabolism along the kynurenine pathway is related to fatigue and anemia, to depression and a decreased quality of life in patients.
This Special Issue of Nutrients is focusing on the association between nutrition and new treatments for anemia in chronic inflammatory disorders. Authors are invited to submit their work, including original research, reviews, meta-research, and opinion papers, showcasing important issues governing nutrition and new treatments for anemia in chronic inflammatory disorders, e.g., are there possibilities to interfere with iron or tryptophan metabolism or supplementation with anti-inflammatory or antioxidant supplements to combat anemia development.
Prof. Dietmar Fuchs
Guest Editor
Manuscript Submission Information
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Keywords
- Cancer
- Cytokines
- Hemoglobin
- Hepcidin
- Infection
- Inflammation
- Interferon-γ
- Iron metabolism
- Macrophages
