Nutrients

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Prof. Dr. Michael Fenech

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Guest Editor

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia
Interests: nutritional, lifestyle, and environmental requirements for DNA damage prevention; impact of nutritional deficiency or excess on chromosomal and telomere integrity; personalized nutrition for healthy aging

Prof. Dr. Duo Li

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Guest Editor

1. Institute of Nutrition & Health, Qingdao University, Qingdao, Peoples R China;
2. Dept Food Science & Nutrition, Zhejiang University, Hangzhou, Peoples R China
Interests: dietary intake and non-communicable diseases; nutrigenetics/nutrigenomics; metabolism of lipids and fatty acids; bioactivity and safety evaluation of novel food and potential natural nutrient resources

Special Issue Information

Dear Colleagues,

Every second year, the Asia-Pacific Nutrigenomics and Nutrigenetics Organisation (APNNO) organizes a conference to gather experts in the field of nutrition and molecular biology to share the results of new research on the impact of nutrition on health at the genome, epigenome, transcriptome, proteome, metabolome, microbiome, and cell levels. We invite you to participate at the conference if you are conducting research on nutrigenomics and nutrigenetics relevant to the Asia-Pacific region and/or its translation into clinical practice. The 2020 APNNO conference will be an online conference held 1–2 December 2020 and organized by the current president of APNNO, Professor Duo Li. Selected papers will be published as the proceedings of the APNNO meeting in this Special Issue.

Prof. Dr. Michael Fenech
Prof. Dr. Duo Li
Guest Editors

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Keywords

nutrition
nutrigenomics
nutrigenetics
personalized nutrition
genome
epigenome
transcriptome
proteome
metabolome
microbiome
health
disease
early development
aging
metabolic disorders
organ function
immune function

Published Papers (1 paper)

Research

12 pages, 1412 KiB

Open AccessArticle

Low Oral Bioavailability and Partial Gut Microbiotic and Phase II Metabolism of Brussels/Witloof Chicory Sesquiterpene Lactones in Healthy Humans

by Hui Weng, Luanying He, Jiakun Zheng, Qing Li, Xiuping Liu and Dongliang Wang

Nutrients 2020, 12(12), 3675; https://doi.org/10.3390/nu12123675 - 28 Nov 2020

Cited by 8 | Viewed by 2359

Abstract

Free and glycosylated sesquiterpene lactones (SLs), which are abundant in leafy vegetables including Brussels/witloof chicory, possess health-promoting effects in vivo. However, the pharmacokinetics of dietary source of SLs remain largely unknown. In this open-label and single-dose trial, sixteen healthy volunteers consumed 150 g of Brussels/witloof chicory juice containing 48.77 μmol SLs in 5 min. Blood, urine, and fecal samples were collected before and after chicory consumption in 24 h. No SLs were detected in the serum, urine, and fecal samples before chicory consumption in all of the participants. Chicory consumption increased lactucin, 11β,13-dihydrolactucin, and their glucuronide/sulfate conjugates, rather than lactucopicrin and 11β,13-dihydrolactucopicrin, as well as glycosylated SLs in biological samples. The peak concentration of total SLs in serum reached 284.46 nmol/L at 1 h, while, in urine, this peak was 220.3 nmol between 2 and 6 h. The recovery of total SLs in blood, urine, and feces was 7.03%, 1.13%, and 43.76% of the ingested dose, respectively. Human fecal suspensions with intestinal microbiota degraded glycosylated SLs in chicory, and converted lactucopicrin and 11β,13-dihydrolactucopicrin to lactucin and 11β,13-dihydrolactucin, respectively. Collectively, Brussels/witloof chicory SLs are poorly bioavailable and they undergo partial gut microbial and phase II metabolism in humans. Full article

(This article belongs to the Special Issue Selected Papers from 3rd Asia-Pacific Nutrigenomics and Nutrigenetics Organisation (APNNO) 2020 Conference)

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