Special Issue "Selected Papers from 3rd Asia-Pacific Nutrigenomics and Nutrigenetics Organisation (APNNO) 2020 Conference"

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: closed (31 March 2021).

Special Issue Editors

Prof. Dr. Michael Fenech
E-Mail Website
Guest Editor
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia
Interests: nutritional, lifestyle, and environmental requirements for DNA damage prevention; impact of nutritional deficiency or excess on chromosomal and telomere integrity; personalized nutrition for healthy aging
Prof. Dr. Duo Li
E-Mail Website
Guest Editor
1. Institute of Nutrition & Health, Qingdao University, Qingdao, Peoples R China;
2. Dept Food Science & Nutrition, Zhejiang University, Hangzhou, Peoples R China
Interests: dietary intake and non-communicable diseases; nutrigenetics/nutrigenomics; metabolism of lipids and fatty acids; bioactivity and safety evaluation of novel food and potential natural nutrient resources

Special Issue Information

Dear Colleagues,

Every second year, the Asia-Pacific Nutrigenomics and Nutrigenetics Organisation (APNNO) organizes a conference to gather experts in the field of nutrition and molecular biology to share the results of new research on the impact of nutrition on health at the genome, epigenome, transcriptome, proteome, metabolome, microbiome, and cell levels. We invite you to participate at the conference if you are conducting research on nutrigenomics and nutrigenetics relevant to the Asia-Pacific region and/or its translation into clinical practice. The 2020 APNNO conference will be an online conference held 1–2 December 2020 and organized by the current president of APNNO, Professor Duo Li. Selected papers will be published as the proceedings of the APNNO meeting in this Special Issue.

Prof. Dr. Michael Fenech
Prof. Dr. Duo Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • nutrigenomics
  • nutrigenetics
  • personalized nutrition
  • genome
  • epigenome
  • transcriptome
  • proteome
  • metabolome
  • microbiome
  • health
  • disease
  • early development
  • aging
  • metabolic disorders
  • organ function
  • immune function

Published Papers (1 paper)

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Research

Open AccessArticle
Low Oral Bioavailability and Partial Gut Microbiotic and Phase II Metabolism of Brussels/Witloof Chicory Sesquiterpene Lactones in Healthy Humans
Nutrients 2020, 12(12), 3675; https://doi.org/10.3390/nu12123675 - 28 Nov 2020
Cited by 1 | Viewed by 690
Abstract
Free and glycosylated sesquiterpene lactones (SLs), which are abundant in leafy vegetables including Brussels/witloof chicory, possess health-promoting effects in vivo. However, the pharmacokinetics of dietary source of SLs remain largely unknown. In this open-label and single-dose trial, sixteen healthy volunteers consumed 150 g [...] Read more.
Free and glycosylated sesquiterpene lactones (SLs), which are abundant in leafy vegetables including Brussels/witloof chicory, possess health-promoting effects in vivo. However, the pharmacokinetics of dietary source of SLs remain largely unknown. In this open-label and single-dose trial, sixteen healthy volunteers consumed 150 g of Brussels/witloof chicory juice containing 48.77 μmol SLs in 5 min. Blood, urine, and fecal samples were collected before and after chicory consumption in 24 h. No SLs were detected in the serum, urine, and fecal samples before chicory consumption in all of the participants. Chicory consumption increased lactucin, 11β,13-dihydrolactucin, and their glucuronide/sulfate conjugates, rather than lactucopicrin and 11β,13-dihydrolactucopicrin, as well as glycosylated SLs in biological samples. The peak concentration of total SLs in serum reached 284.46 nmol/L at 1 h, while, in urine, this peak was 220.3 nmol between 2 and 6 h. The recovery of total SLs in blood, urine, and feces was 7.03%, 1.13%, and 43.76% of the ingested dose, respectively. Human fecal suspensions with intestinal microbiota degraded glycosylated SLs in chicory, and converted lactucopicrin and 11β,13-dihydrolactucopicrin to lactucin and 11β,13-dihydrolactucin, respectively. Collectively, Brussels/witloof chicory SLs are poorly bioavailable and they undergo partial gut microbial and phase II metabolism in humans. Full article
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