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Nutrients
Special Issues
Polyphenols, Bioavailability and Human Health
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Polyphenols, Bioavailability and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 February 2023) | Viewed by 3345

Special Issue Editor

Dr. Lin Han

E-Mail Website
Guest Editor
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China
Interests: molecular nutrition; healthy food

Special Issue Information

Dear Colleagues,

Polyphenols, also known as phenolic compounds, are widely distributed in various plants with one or more aromatic rings bearing at least a hydroxyl substituent. Until now, polyphenols have been demonstrated to reveal lots of health benefits, such as antioxidant, anti-inflammatory, anti-diabetic, anti-cancer activities, etc. However, the bio-efficacy of polyphenols is limited due to their low bioavailability, which is closely related to gastrointestinal tract stability, intestinal absorption rate, and bio-distribution. Therefore, how to increase the bioavailability and effectively play the functional activity of polyphenols causes more and more concerns nowadays. This Special Issue is focused on the bioavailability and health benefits of polyphenols with broad potential topics, including, but not limited to the development of delivery systems for polyphenols, investigation of tissue distribution, and human health of polyphenols. Original research articles and up-to-date reviews are welcome to be submitted.

Dr. Lin Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • bioavailability
  • human health
  • activity

Published Papers (1 paper)

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Review

19 pages, 1916 KiB  
Review
Polyphenols Mediate Neuroprotection in Cerebral Ischemic Stroke—An Update
by Salaheldin Abdelraouf Abdelsalam, Kaviyarasi Renu, Hamad Abu Zahra, Basem M. Abdallah, Enas M. Ali, Vishnu Priya Veeraraghavan, Kalaiselvi Sivalingam, Larance Ronsard, Rebai Ben Ammar, Devanathadesikan Seshadri Vidya, Palaniyandi Karuppaiya, S. Y. Al-Ramadan and Peramaiyan Rajendran
Nutrients 2023, 15(5), 1107; https://doi.org/10.3390/nu15051107 - 23 Feb 2023
Cited by 12 | Viewed by 2974
Abstract
Stroke is one of the main causes of mortality and disability, and it is due to be included in monetary implications on wellbeing frameworks around the world. Ischemic stroke is caused by interference in cerebral blood flow, leading to a deficit in the [...] Read more.
Stroke is one of the main causes of mortality and disability, and it is due to be included in monetary implications on wellbeing frameworks around the world. Ischemic stroke is caused by interference in cerebral blood flow, leading to a deficit in the supply of oxygen to the affected region. It accounts for nearly 80–85% of all cases of stroke. Oxidative stress has a significant impact on the pathophysiologic cascade in brain damage leading to stroke. In the acute phase, oxidative stress mediates severe toxicity, and it initiates and contributes to late-stage apoptosis and inflammation. Oxidative stress conditions occur when the antioxidant defense in the body is unable to counteract the production and aggregation of reactive oxygen species (ROS). The previous literature has shown that phytochemicals and other natural products not only scavenge oxygen free radicals but also improve the expressions of cellular antioxidant enzymes and molecules. Consequently, these products protect against ROS-mediated cellular injury. This review aims to give an overview of the most relevant data reported in the literature on polyphenolic compounds, namely, gallic acid, resveratrol, quercetin, kaempferol, mangiferin, epigallocatechin, and pinocembrin, in terms of their antioxidant effects and potential protective activity against ischemic stroke. Full article
(This article belongs to the Special Issue Polyphenols, Bioavailability and Human Health)
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