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Nutritional Management of Type 2 Diabetes and Its Liver-Associated Complications

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Dr. Flaminia Ferri

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Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
Interests: liver; cirrhosis; disease progression; gastroenterology; disease clinical approach; genetics
Special Issues, Collections and Topics in MDPI journals

Dr. Stefano Ginanni Corradini

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Department of Translational and Precision Medicine, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy
Interests: liver; cirrhosis; disease progression; gastroenterology; disease clinical approach; genetics

Special Issue Information

Dear Colleagues,

We are very pleased to invite researchers to submit original or review papers to this Special Issue, entitled “Nutritional Management of Type 2 Diabetes and Its Liver-Associated Complications”.

This Special Issue aims to explore how nutritional strategies can prevent, manage, or reverse metabolic dysregulations in patients with type 2 diabetes (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), at every stage of its progression—from simple steatosis to advanced liver fibrosis.

This Special Issue welcomes original research, systematic reviews, and meta-analyses addressing the role of macronutrients, micronutrients, supplements, and meal timing on glycemic control, insulin resistance, hepatic fat accumulation, inflammation, and fibrosis progression.

We also encourage submissions on the gut–liver–metabolic axis, focusing on the interplay between gut microbiota, insulin resistance, hepatokines, and the development of liver disease.

Topics of interest also include the impact of specific dietary patterns (e.g., Mediterranean, low-carb, and vegetarian diets) on liver disease in patients with T2DM. Our goal is to provide clinicians and researchers with up-to-date evidence to support personalized and effective nutritional approaches for improving the prognosis of patients with type 2 diabetes and liver-associated diseases at any stage.

Dr. Flaminia Ferri
Dr. Stefano Ginanni Corradini
Guest Editors

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17 pages, 366 KB

Open AccessArticle

Alcohol and Tea Consumption in Relation to Liver Cancer Risk by Diabetes Status: A Prospective Cohort Study of 0.5 Million Chinese Adults

by Xiaoru Feng, Ruoqian Li, Minqing Yan, Changzheng Yuan and You Wu

Nutrients 2025, 17(17), 2870; https://doi.org/10.3390/nu17172870 - 4 Sep 2025

Viewed by 945

Abstract

Background: Liver cancer is a significant disease burden, with metabolic factors potentially influencing its risk. Diabetics, due to metabolic abnormalities, may be more sensitive to environmental exposures. Beverages like tea and alcohol could impact liver cancer risk and may influence prevention in diabetics. Methods: This study included 30,289 diabetics and 482,292 non-diabetics aged 30–79 years from the China Kadoorie Biobank. Baseline alcohol and tea consumption during the past year was collected through questionnaires, including frequency, amount, duration, and types. Incident liver cancer cases were identified from the national health insurance system and local disease registries. Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During a median follow-up of 9.6 years for diabetics and 10.1 years for non-diabetics, 193 (0.69 cases/1000 person-years) and 398 (0.45 cases/1000 person-years) incident liver cancer cases were documented, respectively. Weekly alcohol consumption was associated with higher liver cancer risk in both groups, stronger in diabetics (HR = 1.62; 95% CI: 1.12, 2.34) than in non-diabetics (HR = 1.20, 95% CI: 1.07, 1.35). Among diabetics, the risk was higher in some weekly alcohol consumption subgroups: high-level intake (HR = 2.21; 95% CI: 1.28, 3.80), ≥30 years (HR = 1.70; 95% CI: 1.06, 2.71), or spirit (≥50% alcohol) alcohol-specific consumption (HR = 1.91; 95% CI: 1.20, 3.04), and these associations were stronger than those in non-diabetics. For weekly tea consumption, low-level intake (HR = 0.82; 95% CI: 0.68, 0.99), <10 years (HR = 0.74; 95% CI: 0.58, 0.93), 10–29 years (HR = 0.84; 95% CI: 0.71, 0.99), and green tea-specific consumption (HR = 0.86; 95% CI: 0.75, 0.98) were associated with reduced liver cancer risk in non-diabetics. However, these associations were not significant in those with diabetes. Conclusions: Weekly alcohol consumption is significantly associated with an increased risk of liver cancer, especially in diabetics, while tea consumption appears to lower risk only in non-diabetics, highlighting the need for alcohol reduction in diabetics. Full article

(This article belongs to the Special Issue Nutritional Management of Type 2 Diabetes and Its Liver-Associated Complications)

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