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Nutrition and Frailty/Multimorbidity: Preventive and Clinical Nutritional Management

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 25 December 2025 | Viewed by 425

Special Issue Editor


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Guest Editor
Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences (SCIAC), “Sapienza” University of Rome, 00161 Rome, Italy
Interests: vitamin D; neuropsicologia; anorexia nervosa; calcium; cystic fibrosis; hypertension; spirometry; pain; body composition; metabolism

Special Issue Information

Dear Colleagues,

Nutrition is closely related to the occurrence and development of chronic diseases such as diabetes, hypertension, heart disease, respiratory diseases, and osteoporosis. Reasonable dietary nutrition can not only fundamentally prevent or delay the occurrence of chronic diseases but also affect the prognosis of chronic diseases. This requires clarifying from different perspectives whether specific ingredients in food are effective in preventing and treating chronic diseases or have health-promoting effects, such as zinc and its role in hormone metabolism and carbohydrate, lipid, and protein nutrients.

This Special Issue aims to collate novel research applications on nutrition in preventing and managing frailty and multimorbidity. This includes, but is not limited to, the following:

  1. Diet in diabetic overweight patients.
  2. Oncologic patients with cachexia: what nutritional approach?
  3. Nutritional supplements as an add-on strategy in dementia: are there beneficial substances?
  4. Dietetic approaches in hypertension: sodium correction only?
  5. Role of amino acids’ supplementation in heart failure.
  6. Diet and metabolic syndrome.
  7. Improved absorption in cystic fibrosis.

Dr. Mirella Cilli
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamin D–C–E
  • zinc
  • mineral metabolism
  • bone
  • muscle
  • cardiac failure
  • obesity
  • diabetes

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Published Papers (1 paper)

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Review

13 pages, 444 KiB  
Review
Key Aspects in the Nutritional Management of Polycystic Liver Disease Patients
by Saniya Khan, Simone Di Cola, Silvia Lai, Flaminia Ferri, Vincenzo Cardinale and Manuela Merli
Nutrients 2025, 17(14), 2380; https://doi.org/10.3390/nu17142380 - 21 Jul 2025
Viewed by 174
Abstract
Polycystic liver disease (PLD) is a rare genetic disorder characterized by the development of >10 fluid-filled cysts in the liver. While PLD can occur in isolation, it is most commonly associated with autosomal dominant polycystic kidney disease, adding complexity to its management. PLD [...] Read more.
Polycystic liver disease (PLD) is a rare genetic disorder characterized by the development of >10 fluid-filled cysts in the liver. While PLD can occur in isolation, it is most commonly associated with autosomal dominant polycystic kidney disease, adding complexity to its management. PLD is often asymptomatic but can lead to hepatomegaly, causing symptoms such as abdominal distension, pain and discomfort, early satiety, gastroesophageal reflux, and malnutrition, ultimately affecting patients’ quality of life. Current treatment strategies, including pharmacological and interventional approaches, focus on reducing liver volume and alleviating symptoms. However, management remains largely symptomatic, as no definitive therapies exist to halt cyst progression. Liver transplantation is the only curative option for patients with severe, progressive disease and refractory complications. The EASL guidelines recognize that PLD-related symptoms, primarily due to hepatomegaly, can contribute to involuntary weight loss and recommend assessing symptomatic patients for malnutrition and sarcopenia. Although evidence suggests that patients with PLD may be at risk of malnutrition, original data on the quality and extent of nutritional alterations remain scarce. The potential influence of nutrition on disease progression, symptom burden, and overall well-being is also largely unexplored. Given these knowledge gaps, addressing nutritional challenges, such as early satiety, is essential for optimizing symptom management and maintaining overall nutritional status. This review outlines a possible pathophysiology of malnutrition, specific dietary considerations and recommendations, and weight management in patients with PLD. Additionally, dietary complexities in patients with concurrent renal involvement are discussed, offering a practical framework for clinicians and dietitians in managing this challenging condition. Full article
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