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Effects of Dietary Polyphenols on Metabolic Syndrome

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 15 January 2026 | Viewed by 611

Special Issue Editor


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Guest Editor
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China
Interests: polyphenols; metabolic syndrome; obesity; antioxidants; neuroscience; functional foods; composition analysis

Special Issue Information

Dear Colleagues,

Metabolic syndrome, a cluster of interrelated metabolic abnormalities including insulin resistance, dyslipidemia, hypertension, and abdominal obesity, has emerged as a global health challenge, significantly increasing the risk of cardiovascular disease, type 2 diabetes, and other chronic conditions. As the prevalence of this syndrome continues to rise, due to modern lifestyles, sedentary behaviors, and unhealthy dietary patterns, there is an urgent need for effective strategies to prevent and manage it. In recent years, the potential of dietary polyphenols to modulate metabolic processes and improve health outcomes has garnered increasing attention. These dietary polyphenols, found in various foods and beverages, possess diverse biological activities, such as antioxidant, anti-inflammatory, and lipid-lowering effects, which may contribute to the prevention and amelioration of metabolic syndrome. This Special Issue aims to compile cutting-edge research exploring the effects of dietary polyphenols on metabolic syndrome. We invite original research articles, reviews, and perspectives that delve into the mechanisms of action, efficacy, and potential applications of these ingredients in the context of metabolic syndrome. By highlighting novel findings and innovative approaches, this Special Issue seeks to advance our understanding and foster further research in this promising area, ultimately providing valuable insights for the development of dietary interventions and functional foods to combat metabolic syndrome and improve public health.

Dr. Yali Zhang
Guest Editor

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Keywords

  • metabolic syndrome
  • dietary polyphenols
  • chronic diseases
  • dietary interventions
  • antioxidant
  • anti-inflammatory
  • lipid-lowering
  • cancer
  • prevention and management
  • public health

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Published Papers (1 paper)

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Research

23 pages, 2763 KB  
Article
Clinical Implementation of Sustainable Functional Foods and Nutraceuticals in Metabolic Health: A Feasibility Study
by Francesca Scionti, Samantha Maurotti, Elisa Mazza, Angela Mirarchi, Raffaella Russo, Paola Doria, Rosario Mare, Giuseppe Marafioti, Yvelise Ferro, Tiziana Montalcini and Arturo Pujia
Nutrients 2025, 17(24), 3858; https://doi.org/10.3390/nu17243858 - 10 Dec 2025
Viewed by 340
Abstract
Background: Diet quality significantly influences metabolic health, obesity, and non-communicable disease risk. Functional foods and nutraceuticals, rich in bioactive compounds, may enhance health outcomes beyond basic nutrition, particularly when combined with Mediterranean-style dietary patterns. Objectives: This feasibility study evaluated the integration of functional [...] Read more.
Background: Diet quality significantly influences metabolic health, obesity, and non-communicable disease risk. Functional foods and nutraceuticals, rich in bioactive compounds, may enhance health outcomes beyond basic nutrition, particularly when combined with Mediterranean-style dietary patterns. Objectives: This feasibility study evaluated the integration of functional foods and nutraceuticals into a Mediterranean-based dietary intervention in adults with metabolic risk factors, focusing on feasibility, tolerability, and preliminary clinical effects. Methods: Functional food prototypes, including Calabrian tomato, pomegranate, bergamot, blueberry, and hazelnut products, along with two nutraceutical formulations, were developed, characterized for bioactive content, and assessed for palatability, bioavailability, and safety. Adults aged ≥50 years participated in a 4-week intervention, consuming daily servings of functional foods and either a whey protein-based or essential amino acid-based nutraceutical. Compliance, acceptability, anthropometry, body composition, muscle strength, and biochemical markers were assessed pre- and post-intervention. Results: Functional foods and nutraceuticals were well-tolerated, with high adherence (>80%). Bioactive compounds were detectable in serum post-consumption, confirming bioavailability. Preliminary findings suggested that integrating functional foods and nutraceuticals into a Mediterranean-style dietary intervention is feasible, safe, and acceptable in older adults with metabolic risk factors. These results support the potential clinical benefit of combined dietary strategies and provide a rationale for a larger randomized controlled trial to evaluate efficacy on metabolic, musculoskeletal, and hepatic outcomes. Full article
(This article belongs to the Special Issue Effects of Dietary Polyphenols on Metabolic Syndrome)
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