Precision Nutrition in Autoimmune and Inflammatory Disorders

Dear Colleagues,

Autoimmune and inflammatory disorders, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, are closely linked to nutritional status. The practical application of a personalized approach, i.e., precision nutrition, based on genetics, metabolic needs, and immunological profiles, offers a promising strategy for managing these chronic disorders.

Recent research has highlighted the potential of dietary interventions to influence immune responses, decrease systemic inflammation, and improve quality of life. Among the specific nutrients and bioactive compounds are vitamin D, omega-3 fatty acids, polyphenols, trace elements, and anti-inflammatory dietary patterns. Addressing deficiencies in patients with chronic inflammation is essential for achieving optimal clinical outcomes.

The underlying concept of precision nutrition considers these compounds not as pharmacological agents, but as essential nutritional support needed for the regulated responses to inflammation and autoimmunity. When dysregulation occurs due to deficiency, often because of chronic inflammatory activity, certain biochemical pathways are impaired and immune responses are weakened. The aim is to restore the nutritional balance after identifying the specific needs by a personalized adjuvant targeted supplementation. The potential of precision nutrition is promising for patients, practitioners and researchers alike, but prevention, routine application and long-term patient adherence are the major challenges we are facing.

Prof. Dr. Lutz Schomburg
Dr. Mahsa Jalili
Guest Editors

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