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Dietary Phytochemicals: Natural Swords Combating Inflammation

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 25 January 2025 | Viewed by 1966

Special Issue Editor


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Guest Editor
Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
Interests: molecular nutrition; inflammation; antioxidant; dietary phytochemicals

Special Issue Information

Dear Colleagues,

Diet has complex and multidimensional effects on physiological and immuneregulatory processes. The consumption of plant ingredients (phytochemicals), including polyphenols, polysaccharose, etc., exhibits various biological activities such as anti-oxidation and anti-inflammatory effects, which have attracted extensive attention for the prevention of metabolic and inflammatory-related diseases. On the other hand, some phytochemicals, such as anti-nutritional factors and allergens, also induce allergic reaction and chronic diseases by recruiting inflammatory cells and promoting the secretion of pro-inflammatory cytokines in the gastrointestinal tract, which is detrimental to human health.

Thus, the purpose of this Special Issue is to collect and discuss the recent developments regarding the regulatory role and molecular mechanism of new phytochemicals or their composite effect on inflammatory pathways (inhibiting or promoting), which are involved in metabolic disorders and human health. This better understanding of phytochemicals regulating inflammation can improve the use of currently available treatments and prevention against inflammatory and metabolic diseases or design of novel therapeutic strategies against allergic inflammation. This Special Issue will include both original research and systematic reviews.

Prof. Dr. Jianxiong Xu
Guest Editor

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Keywords

  • phytochemicals
  • inflammation
  • metabolic diseases
  • composite effect

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Published Papers (1 paper)

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Research

17 pages, 5465 KiB  
Article
Antioxidant and Anti-Inflammatory Properties of Conceivable Compounds from Glehnia littoralis Leaf Extract on RAW264.7 Cells
by Min Yeong Park, Hun Hwan Kim, Se Hyo Jeong, Pritam Bhangwan Bhosale, Abuyaseer Abusaliya, Hyun Wook Kim, Je Kyung Seong, Kwang Il Park and Gon Sup Kim
Nutrients 2024, 16(21), 3656; https://doi.org/10.3390/nu16213656 - 27 Oct 2024
Viewed by 1410
Abstract
Background/Objectives: Glehnia littoralis is a medicinal plant, but the scientific basis is still unclear. This study thoroughly investigated phenols from Glehnia littoralis extract (GLE) to determine their potential as anti-inflammatory and antioxidant agents. Methods: High-performance liquid chromatography (HPLC) and mass spectrometry (MS) were [...] Read more.
Background/Objectives: Glehnia littoralis is a medicinal plant, but the scientific basis is still unclear. This study thoroughly investigated phenols from Glehnia littoralis extract (GLE) to determine their potential as anti-inflammatory and antioxidant agents. Methods: High-performance liquid chromatography (HPLC) and mass spectrometry (MS) were used to analyze the compounds in GLE. In addition, we performed GLE in vitro in macrophages after lipopolysaccharide (LPS)-induced inflammation. Results: The extract contained eight peaks representing phenolic compounds and one peak representing riboflavin, with the corresponding mass spectrometry data documented. These biologically active compounds were purified by ultrafiltration using LC to determine their ability to target cyclooxygenase-2 (COX-2) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The results showed that significant compounds were identified, demonstrating a binding affinity for both COX-2 and DPPH. This suggests that the compounds showing excellent binding affinity for COX-2 and DPPH may be the main active ingredients. Vital inflammatory cytokines, including COX-2, inducible nitric oxide synthase (iNOS), mitogen-activated protein kinase (MAPK), and nuclear factor kappa B (NF-κB), were found to be down-regulated during the treatment. In addition, we revealed that the selected drugs exhibited potent binding capacity to inflammatory factors through molecular docking studies. In addition, we confirmed the presence of phenolic components in GLE extract and verified their possible anti-inflammatory and antioxidant properties. Conclusions: This study provided evidence for an efficient strategy to identify critical active ingredients from various medicinal plants. These data may serve as a baseline for further investigations of applying GLE in the pharmaceutical industry. Full article
(This article belongs to the Special Issue Dietary Phytochemicals: Natural Swords Combating Inflammation)
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