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Nutrients
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Nutritional Interventions for Age-Related Diseases
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Nutritional Interventions for Age-Related Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 1512

Special Issue Editor

Dr. Jeannette M. Beasley

E-Mail Website
Guest Editor
Department of Nutrition and Food Studies and Medicine, New York University, New York, NY, USA
Interests: aging; health disparities; woman's health; diet quality; dietary proteins; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Established as well as emerging evidence indicates diet and nutrition play an important role in aging and impact the development of age-related diseases. It is crucial to identify dietary and lifestyle factors that may affect aging and health, especially among older individuals that have been historically underrepresented in research. Dietary components with anti-aging effects may slow or prevent the development of cardiovascular and cerebrovascular diseases, neurodegenerative diseases, cognitive impairment, and dementia.

This Special Issue aims to explore the role of dietary patterns and nutritional interventions among older adults, with a particular focus on their effects on age-related diseases, including metabolic disorders, inflammation, chronic diseases, cognitive impairment, skeletal muscle mass, etc. The ultimate question is whether nutritional interventions can have a positive impact on aging and health in older adults.

We welcome your submissions to this Special Issue, “Nutritional Interventions for Age-Related Diseases”.

Dr. Jeannette M. Beasley
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • older adults
  • dietary patterns
  • nutritional intervention
  • age-related disease
  • physical health
  • cognition
  • cardiovascular disease
  • metabolic disease
  • sarcopenia
  • quality of life

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Published Papers (1 paper)

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Research

16 pages, 582 KiB  
Article
The Role of Nutrition and Other Lifestyle Patterns in Mortality Risk in Older Adults with Multimorbidity
by Chao Dong, Karen A. Mather, Henry Brodaty, Perminder S. Sachdev, Julian Trollor, Fleur Harrison, Dana Bliuc, Rebecca Ivers, Joel Rhee and Zhaoli Dai
Nutrients 2025, 17(5), 796; https://doi.org/10.3390/nu17050796 - 25 Feb 2025
Viewed by 905
Abstract
Background: Limited research has examined how older adults’ lifestyles intersect with multimorbidity to influence mortality risk. Methods: In this community-dwelling prospective cohort, the Sydney Memory and Ageing Study, principal component analysis was used to identify lifestyle patterns using baseline self-reported data on nutrition, [...] Read more.
Background: Limited research has examined how older adults’ lifestyles intersect with multimorbidity to influence mortality risk. Methods: In this community-dwelling prospective cohort, the Sydney Memory and Ageing Study, principal component analysis was used to identify lifestyle patterns using baseline self-reported data on nutrition, lifestyle factors, and social engagement activities. Multimorbidity was defined by self-reported physician diagnoses. Multivariable logistic regression was used to estimate odds ratios (ORs) for multimorbidity cross-sectionally, and Cox proportional hazards models were used to assess hazard ratios (HRs) for mortality risk longitudinally. Results: Of 895 participants (mean age: 78.2 years; 56.3% female) with complete lifestyle data, 597 had multimorbidity. Two distinct lifestyle patterns emerged: (i) a nutrition pattern characterised by higher intakes of protein, fibre, iron, zinc, magnesium, potassium, and folate, and (ii) an exercise-sleep-social pattern marked by weekly physical activities like bowling, bicycling, sleep quality (low snoring/sleepiness), and high social engagement. Neither pattern was associated with multimorbidity cross-sectionally. Over a median 5.8-year follow-up (n = 869; 140 deaths), participants in the upper tertiles for combined lifestyle pattern scores had a 20% lower mortality risk than those in the lowest tertile [adjusted HR: 0.80 (95% CI: 0.65–0.97); p-trend = 0.02]. This association was stronger in participants with multimorbidity, with a 29% lower risk [0.71 (0.56–0.89); p-trend = 0.01], likely due to multimorbidity modifying the relationship between nutrition and mortality risk (p-interaction < 0.05). While multimorbidity did not modify the relationship between the exercise-sleep-social pattern and risk of mortality, it was consistently associated with a 19–20% lower risk (p-trend < 0.03), regardless of the multimorbidity status. Conclusions: Older adults with multimorbidity may particularly benefit from adopting healthy lifestyles focusing on nutrition, physical activity, sleep quality, and social engagement to reduce their mortality risk. Full article
(This article belongs to the Special Issue Nutritional Interventions for Age-Related Diseases)
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