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Nutrition and Nutraceuticals for Pain Prevention and Treatment

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 3756

Special Issue Editors


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Guest Editor
Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Sciences, University “Magna Graecia” of Catanzaro, Viale Europa, Loc. Germaneto, 88100 Catanzaro, Italy
Interests: pain assessment; pain management; pain biomarker; free radicals in pain; antioxidants; pain epigenetics; nutraceuticals for pain management
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Center for Neuroplasticity and Pain (CNAP), SMI®, Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark
Interests: pain assessment; pain management; pain biomarker; pain prevention; free radicals; antioxidants; pain epigenetics; inflammatory markers

Special Issue Information

Dear Colleagues,

Integrative and personalized health places a strong emphasis on diet and nutrition because of their significant effects on the body and longevity. Lifestyle changes are a general threat towards health status of societies and hence increase societal health care costs. Food habits have an impact on both wellness and disease.

For example, in the integrative management of a wide range of pain conditions, dietary patterns such as the Mediterranean diet are mainstay possibly due to their anti-inflammatory and antioxidant beneficial effects.

Mechanistic research has demonstrated that the anti-inflammatory and antioxidant properties of polyphenols found in the Mediterranean diet are beneficial for inflammation and to some degree for chronic pain.

Prioritizing a healthy diet with proper nutrition and nutraceutical supplements remains a key factor among the modifiable behaviors.

Addressing this complexity requires a comprehensive examination of how nutrients and nutraceuticals work in the body, particularly in the context of chronic pain prevention and management.

This can include research on any chronic pain condition and can cover areas such as gastrointestinal function, musculoskeletal integrity, the gut–brain axis, immune function, inflammation, free radicals and oxidative stress, telomer shortening, epigenetic modifications, preventive/healing effects of diet, and research into how diet affects pain neurotransmission.

Different types of manuscripts, including original clinical research articles and up-to-date reviews (systematic reviews and meta-analyses), are welcome.

Dr. Carolina Muscoli
Dr. Lars Arendt-Nielsen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • nutrition
  • nutraceuticals
  • pain
  • widespread chronic pain
  • inflammation
  • supplements
  • epigenetics
  • oxidative stress

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Published Papers (1 paper)

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Review

38 pages, 452 KiB  
Review
Exploring the Potential of Dietary Supplements to Alleviate Pain Due to Long COVID
by Nicoletta Marchesi, Massimo Allegri, Giacomo Matteo Bruno, Alessia Pascale and Stefano Govoni
Nutrients 2025, 17(7), 1287; https://doi.org/10.3390/nu17071287 - 7 Apr 2025
Viewed by 3385
Abstract
Long COVID, characterized by persistent symptoms following COVID-19 infection, significantly impacts individuals’ health and daily functioning due to fatigue and pain. Focusing on pain, this review addresses nociplastic and chronic pain conditions. Interventions designed to reduce inflammation, oxidative stress, and enhance vagal activity [...] Read more.
Long COVID, characterized by persistent symptoms following COVID-19 infection, significantly impacts individuals’ health and daily functioning due to fatigue and pain. Focusing on pain, this review addresses nociplastic and chronic pain conditions. Interventions designed to reduce inflammation, oxidative stress, and enhance vagal activity may offer a promising approach to managing post-pandemic pain. This review presents individual components of food supplements with demonstrated efficacy in one or more pain conditions, focusing on their proposed mechanisms and clinical activity in pain, including their use in post-COVID-19 pain when available. Many of these substances have a long history of safe use and may offer an alternative to long-term analgesic drug treatment, which is often associated with potential side effects. This review also explores the potential for synergistic effects when combining these substances with each other or with conventional analgesics, considering the advantages for both patients and the healthcare system in using these substances as adjunctive or primary therapies for pain symptoms related to long COVID. While preclinical scientific literature provides a mechanistic basis for the action of several food supplements on pain control mechanisms and signaling pathways, clinical experience, particularly in the field of long COVID-associated pain, is still limited. However, the reviewed literature strongly suggests that the use of food supplements in long COVID-associated pain is an attainable goal, provided that rigorous clinical trials are conducted. Full article
(This article belongs to the Special Issue Nutrition and Nutraceuticals for Pain Prevention and Treatment)
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