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Nutritional Influences on Cognitive Function and Neurodevelopment Across the Lifespan

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Neuro Sciences".

Deadline for manuscript submissions: 1 July 2025 | Viewed by 1784

Special Issue Editors


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Guest Editor
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Interests: lifecourse exposures; biology; mental health

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Guest Editor Assistant
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Interests: anti Inflammatory diets; dietary neuroinflammation

Special Issue Information

Dear Colleagues,

As you certainly know, the intricate relationship between nutrition and brain health has become an increasingly important area of research. For this reason, we are pleased to invite you to contribute to our upcoming Special Issue, "Nutritional Influences on Cognitive Function and Neurodevelopment Across the Lifespan", in the Nutrients journal.

The brain relies on a consistent supply of essential nutrients for optimal functioning, from early development to maintaining cognitive health in aging. However, genetic predispositions, epigenetic modifications, and environmental factors can interact with nutritional status to impact brain development and function. Imbalances in these interactions can contribute to developmental disorders in childhood, compromised cognitive abilities in adulthood, and an increased risk of age-related cognitive decline and neurodegenerative diseases.

This Special Issue aims to explore the critical role of nutrition in shaping cognitive function and neurodevelopment throughout all stages of life. We encourage the submission of original research articles, reviews, and meta-analyses. Potential topics include but are not limited to nutritional influences on fetal brain development and early childhood cognition, dietary patterns and their long-term effects on brain health, the gut microbiome and its relation to cognitive

function, or dietary interventions for preventing or mitigating age-related cognitive decline.

We look forward to hearing your response and reviewing your submissions in the near future.

Prof. Dr. Dolores Malaspina
Guest Editor

Dr. Ezequiel Lafont
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • neurodevelopment
  • cognition
  • dietary habits
  • micronutrients and cognition
  • neurodegenerative diseases
  • gut microbiome and brain
  • food allergies
  • early life nutrition
  • cognitive aging
  • nutritional interventions
  • processed food addiction

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Published Papers (1 paper)

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Review

24 pages, 3495 KiB  
Review
Dietary Patterns and Brain Health in Middle-Aged and Older Adults: A Narrative Review
by Jamie A. Seabrook, Abolfazl Avan, Colleen O’Connor, Harry Prapavessis, Lindsay Nagamatsu, Jasna Twynstra, Saverio Stranges, Arlene MacDougall and Vladimir Hachinski
Nutrients 2025, 17(9), 1436; https://doi.org/10.3390/nu17091436 - 24 Apr 2025
Viewed by 1542
Abstract
Diet has a profound impact on brain health, particularly in middle-aged and older adults, who are at increased risk of cognitive decline and neurodegenerative diseases. Various dietary patterns, including the Mediterranean diet (MedDiet), Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for [...] Read more.
Diet has a profound impact on brain health, particularly in middle-aged and older adults, who are at increased risk of cognitive decline and neurodegenerative diseases. Various dietary patterns, including the Mediterranean diet (MedDiet), Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets, have been linked to improved cognitive function. While the relative effectiveness of these diets on brain health is generally supported by evidence, variability in study results suggests that further research is needed to fully understand their effects across diverse populations. The objective of this descriptive narrative review is to examine the role of dietary patterns in supporting brain health in aging populations and to propose practical dietary strategies for promoting cognitive well-being. A comprehensive review of the existing literature was conducted on PubMed in October 2024, with no restrictions on language, publication date (1966–2024), or geographic location. A total of 18 articles were included in this review, covering the years 2013–2023. Studies assessing the impact of the MedDiet, DASH, MIND, and Western diets on cognitive function in middle-aged and older adults were prioritized. The research findings were synthesized to identify common and unique recommendations across these dietary patterns. The MedDiet consistently showed beneficial effects on cognitive health, including improved memory, processing speed, and long-term protection against neurodegenerative conditions. The DASH and MIND diets demonstrated potential benefits, particularly for specific cognitive domains, but the results were more mixed and inconclusive. In contrast, adherence to a Western diet was associated with negative cognitive outcomes, including cognitive decline and smaller brain volumes. These findings underscore the importance of adopting healthy dietary patterns as a modifiable lifestyle factor to support cognitive aging and inform future public health strategies and clinical guidelines. Full article
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