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Nutrients
Special Issues
Advances in Gut Microbial Genomics and Metabolomics in Human Health
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Advances in Gut Microbial Genomics and Metabolomics in Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: closed (25 July 2025) | Viewed by 823

Special Issue Editors

Dr. Hea-jong Chung

E-Mail Website
Guest Editor
Gwanju Center, Korea Basic Science Institute, Gwanju 61715, Republic of Korea
Interests: microbiome; gut microbiome; brain diseases; neurobiology; probiotics
Special Issues, Collections and Topics in MDPI journals
Dr. Ji-Seon Ahn

E-Mail Website
Guest Editor
Korea Basic Science Institute, Gwangju, Republic of Korea
Interests: gut microbiome; fecal microbiome; neuroprotection; neurobiology; neuropathology

Special Issue Information

Dear Colleagues,

This Special Issue will explore the latest advancements in gut microbial genomics and metabolomics, highlighting their critical role in human health. The human microbiome is integral to various physiological processes, including digestion, metabolism, and immune function, with disruptions linked to diseases such as obesity, diabetes, cardiovascular disorders, and neurological conditions. Recent innovations in genomics and metabolomics have deepened our understanding of microbial diversity and the metabolites that microbes produce, providing insights into their impacts on health and disease. We welcome contributions that address the molecular mechanisms behind gut microbiome dysbiosis, the role of microbial metabolites in metabolic and immune regulation, and how these insights can lead to new therapeutic approaches for chronic diseases. Studies investigating the effects of diet, lifestyle, and environmental factors on microbiome composition, as well as the potential of microbiome-based therapies, are also encouraged. This Special Issue will provide a comprehensive platform for the latest research on microbial genomics and metabolomics, advancing our understanding of the microbiome’s role in human health and disease prevention.

Dr. Hea-jong Chung
Dr. Ji-Seon Ahn
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiome
  • metabolomics
  • health
  • metagenomics
  • disease

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Published Papers (1 paper)

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Research

25 pages, 3717 KiB  
Article
A Prebiotic Diet Containing Galactooligosaccharides and Polydextrose Attenuates Hypergravity-Induced Disruptions to the Microbiome in Female Mice
by Robert S. Thompson, Shelby Hopkins, Tel Kelley, Christopher G. Wilson, Michael J. Pecaut and Monika Fleshner
Nutrients 2025, 17(15), 2417; https://doi.org/10.3390/nu17152417 - 24 Jul 2025
Viewed by 573
Abstract
Background/Objectives: Environmental stressors, including spaceflight and altered gravity, can negatively affect the symbiotic relationship between the gut microbiome and host health. Dietary prebiotics, which alter components of the gut microbiome, show promise as an effective way to mitigate the negative impacts of stressor [...] Read more.
Background/Objectives: Environmental stressors, including spaceflight and altered gravity, can negatively affect the symbiotic relationship between the gut microbiome and host health. Dietary prebiotics, which alter components of the gut microbiome, show promise as an effective way to mitigate the negative impacts of stressor exposure. It remains unknown, however, if the stress-protective effects of consuming dietary prebiotics will extend to chronic altered-gravity exposure. Methods: Forty female C57BL/6 mice consumed either a control diet or a prebiotic diet containing galactooligosaccharides (GOS) and polydextrose (PDX) for 4 weeks, after which half of the mice were exposed to 3 times the gravitational force of Earth (3g) for an additional 4 weeks. Fecal microbiome samples were collected weekly for 8 weeks, sequenced, and analyzed using 16S rRNA gene sequencing. Terminal physiological endpoints, including immune and red blood cell characteristics, were collected at the end of the study. Results: The results demonstrate that dietary prebiotic consumption altered the gut microbial community structure through changes to β-diversity and multiple genera across time. In addition, consuming dietary prebiotics reduced the neutrophil-to-lymphocyte ratio (NLR) and increased red blood cell distribution width (RDW-CV). Importantly, the prebiotic diet prevented the impacts of altered-gravity on β-diversity and the bloom of problematic genera, such as Clostridium_sensu_stricto_1 and Turicibacter. Furthermore, several prebiotic diet-induced genera-level changes were significantly associated with several host physiological changes induced by 3g exposure. Conclusions: These data demonstrate that the stress-protective potential of consuming dietary prebiotics extends to environmental stressors such as altered gravity, and, potentially, spaceflight. Full article
(This article belongs to the Special Issue Advances in Gut Microbial Genomics and Metabolomics in Human Health)
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