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Nutrients
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Prevention, Management and Treatment of Bone-Related Diseases Using Natural Products
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Prevention, Management and Treatment of Bone-Related Diseases Using Natural Products

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (15 April 2025) | Viewed by 1274

Special Issue Editors

Prof. Dr. Radoslav Omelka

E-Mail Website
Guest Editor
Department of Botany and Genetics, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, 949 01 Nitra, Slovakia
Interests: natural products; pharmacological agents; bone biology; bone-related diseases; osteoporosis; diabetes
Prof. Dr. Monika Martiniaková

E-Mail Website
Guest Editor
Department of Zoology and Anthropology, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, 949 01 Nitra, Slovakia
Interests: natural products; pharmacological agents; bone biology; bone-related diseases; osteoporosis; diabetes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue on natural products aims to provide a comprehensive overview of their potential use in the prevention, management, and treatment of a wide range of bone-related diseases such as osteoporosis, inflammatory joint diseases, osteopetrosis, diabetes mellitus, obesity, and bone cancer. Natural products are a rich source of bioactive compounds with valuable applications in several industries, such as pharmaceuticals, medicine, food, and biotechnology. The high structural and physicochemical diversity of natural molecules produced by plants, fungi, microorganisms, and insects makes them a practically inexhaustible resource with the potential to aid in the discovery and development of new bioactive compounds with applications in the aforementioned industries. There is a growing interest in medicinal and bioactive compounds obtained from natural products for their significant health benefits.

We invite original research articles and review articles covering the molecular, biochemical, morphological, pharmaceutical, and medical aspects of these topics. We look forward to your valuable contributions and advances in the field of natural products associated with bone-related diseases.

Prof. Dr. Radoslav Omelka
Prof. Dr. Monika Martiniaková
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • bone-related diseases
  • osteoporosis
  • inflammatory joint diseases
  • diabetes mellitus
  • obesity
  • bone cancer
  • prevention
  • management
  • treatment

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Published Papers (1 paper)

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Research

16 pages, 2109 KiB  
Article
Effect of Chrysin, a Flavonoid Present in Food, on the Skeletal System in Rats with Experimental Type 1 Diabetes
by Sylwia Klasik-Ciszewska, Piotr Londzin, Kacper Grzywnowicz, Weronika Borymska, Maria Zych, Ilona Kaczmarczyk-Żebrowska and Joanna Folwarczna
Nutrients 2025, 17(2), 316; https://doi.org/10.3390/nu17020316 - 16 Jan 2025
Viewed by 965
Abstract
Background: It seems that some substances of plant origin may exert health-promoting activities in diabetes and its complications, including those concerning bones. Chrysin (5,7-dihydroxyflavone), present in honey, some plants, and food of plant origin, has been reported to exert, among others, antioxidative, anti-inflammatory [...] Read more.
Background: It seems that some substances of plant origin may exert health-promoting activities in diabetes and its complications, including those concerning bones. Chrysin (5,7-dihydroxyflavone), present in honey, some plants, and food of plant origin, has been reported to exert, among others, antioxidative, anti-inflammatory and antidiabetic effects. The aim of this study was to investigate the effects of chrysin on the skeletal system of rats with experimental type 1 diabetes (T1D). Methods: The experiments were carried out on mature male Wistar rats. T1D was induced by a single streptozotocin injection. Administration of chrysin (50 or 100 mg/kg p.o., once daily) began two weeks later and lasted four weeks. Serum bone turnover markers, bone mass, density and mineralization, mechanical properties and histomorphometric parameters of cancellous and compact bone were examined. Results: T1D profoundly affected bone metabolism, leading to worsening of bone strength in comparison with the healthy controls. After administration of chrysin, slight improvement of only some parameters was demonstrated in relation to the diabetic controls. Conclusions: Results of the present study indicate that chrysin may exert some very limited favorable effects on the skeletal system in diabetic conditions. Full article
(This article belongs to the Special Issue Prevention, Management and Treatment of Bone-Related Diseases Using Natural Products)
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