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Dietary Approaches to Prevent Hypertension

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 5 July 2024 | Viewed by 1112

Special Issue Editor

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Guest Editor
1. Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain
2. Instituto de Investigación Biosanitaria de Granada (ibs. GRANADA), 18012 Granada, Spain
Interests: immune system; gut microbiota; trained immunity; cardiovascular disease; probiotics
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Special Issue Information

Dear Colleagues,

Hypertension is one of the most powerful risk factors for cardiovascular events, including stroke and myocardial infarction. Around one-quarter of the world’s population is considered hypertensive, and this condition is responsible for about 41% of cardiovascular disease-related deaths. Treatment using antihypertensive drugs can reduce the risk of major cardiovascular events. Currently, it is estimated that 10–30% of the general hypertensive population presents with resistant hypertension, which is defined as high BP that cannot be adequately controlled using three different classes of antihypertensive agents, one of which is a diuretic. These data support the need for the development of novel therapeutic targets for hypertension.

Recently, an imbalance in the gut microbiota composition relative to its healthy state, termed dysbiosis, has been associated with hypertension; however, the mechanisms involved in BP regulation that are controlled by the microbiota have not yet been fully elucidated. It is essential to maintain the delicate balance in the gut microbiota to achieve intestinal immunity and whole-body homeostasis. Therefore, manipulating the gut microbiota through dietetic manipulation or the use of probiotics, prebiotics, or postbiotics may lead to the development of novel antihypertensive therapies.

This Special Issue will focus on basic and translational research and clinical evidence to achieve complete comprehension of how modulating the gut microbiota is involved in hypertension. Research will also consider the role of the immune system and the sympathetic nervous system.

Dr. Iñaki Robles-Vera
Guest Editor

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  • gut microbiota
  • cardiovascular disease
  • diet
  • probiotics
  • prebiotics

Published Papers (1 paper)

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14 pages, 616 KiB  
Dietary Fructose and Sodium Consumed during Early Mid-Life Are Associated with Hypertensive End-Organ Damage by Late Mid-Life in the CARDIA Cohort
by Dragana Komnenov, Mohammad Al-Hadidi, Hamza Ali, Malik Al-Jamal, Kassim Salami, Samy Shelbaya, Kareem Tayeb, Daniel Domin and Rana Elhamzawy
Nutrients 2024, 16(7), 913; - 22 Mar 2024
Viewed by 914
We aimed to investigate how dietary fructose and sodium impact blood pressure and risk of hypertensive target organ damage 10 years later. Data from n = 3116 individuals were obtained from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Four groups [...] Read more.
We aimed to investigate how dietary fructose and sodium impact blood pressure and risk of hypertensive target organ damage 10 years later. Data from n = 3116 individuals were obtained from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Four groups were identified based on the four possible combinations of the lower and upper 50th percentile for sodium (in mg) and fructose (expressed as percent of total daily calories). Differences among groups were ascertained and logistic regression analyses were used to assess the risk of hypertensive target organ damage (diastolic dysfunction, coronary calcification and albuminuria). Individuals in the low-fructose + low-sodium group were found to have lower SBP compared to those in the low-fructose + high-sodium and high-fructose + high-sodium groups (p < 0.05). The highest risk for hypertensive target organ damage was found for albuminuria only in the high-fructose + high-sodium group (OR = 3.328, p = 0.006) while female sex was protective across all groups against coronary calcification. Our findings highlight that sodium alone may not be the culprit for hypertension and hypertensive target organ damage, but rather when combined with an increased intake of dietary fructose, especially in middle-aged individuals. Full article
(This article belongs to the Special Issue Dietary Approaches to Prevent Hypertension)
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