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Maternal and Child Nutrition: From Pregnancy to Early Life

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 15 March 2026 | Viewed by 118

Special Issue Editors


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Guest Editor
Division of Obstetrics, Medical University of Graz, Graz, Austria
Interests: human milk oligosaccharides (HMOs); pregnancy; maternal metabolism; gestational diabetes mellitus; maternal metabolic and cardiovascular health outcomes; pregnancy and early life microbiome; glycobiology; human milk and lactation

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Guest Editor
Division of Obstetrics, Medical University of Graz, Graz, Austria
Interests: fetal programming; metabolic derangements in pregnancy; gestational diabetes; epigenetic modifications; cellular function; endothelial biology; endothelial progenitor cells; early life cardiovascular and metabolic risk; neonatal adiposity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Optimal nutrition during pregnancy and early life plays a critical role in shaping both immediate and long-term health outcomes for mother and child. This Special Issue of Nutrients invites original research and comprehensive reviews that explore the complex interplay between maternal nutrition, pregnancy-related metabolic adaptations, and the developmental programming of fetal and neonatal health.

We welcome contributions exploring how maternal diet, metabolic conditions, and pregnancy complications such as gestational diabetes and hypertensive disorders impact fetal development, neonatal outcomes, and long-term risk of metabolic and cardiovascular diseases. Particular emphasis will be placed on mechanisms of placental function, maternal metabolic and cardiovascular adaptations, and how these influence neonatal body composition, including early-onset adiposity.

This Special Issue will also highlight the role of human milk components, particularly human milk oligosaccharides (HMOs), in shaping infant metabolism, immunity, and the gut microbiome.

Studies addressing early-life nutritional programming, biomarkers of metabolic health, and interventions to optimize outcomes for at-risk pregnancies are especially welcome.

Topics of interest include, but are not limited to, the following:

  • Maternal nutrition and dietary interventions during pregnancy and lactation;
  • Metabolic and cardiovascular adaptations in pregnancy;
  • Placental function and nutrient transfer;
  • Gestational diabetes, obesity, and other pregnancy-related metabolic disorders;
  • Nutritional and metabolic programming of fetal and neonatal health;
  • Neonatal adiposity and early markers of cardiometabolic risk;
  • Human milk composition and function, including human milk oligosaccharides;
  • Translational and interventional studies to optimize maternal and child nutrition.

By spanning the continuum from pregnancy to early infancy, this Special Issue aims to deepen our understanding of maternal and child nutrition as a foundation for lifelong health.

Dr. Evelyn Jantscher-Krenn
Dr. Ursula Hiden
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • maternal nutrition
  • pregnancy metabolism
  • developmental programming
  • gestational diabetes
  • maternal obesity
  • neonatal adiposity
  • human milk oligosaccharides (HMOs)
  • early-life nutrition
  • placental function
  • cardiometabolic health

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Published Papers (1 paper)

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Research

17 pages, 340 KB  
Article
Antioxidant Capacity of Colostrum of Mothers with Gestational Diabetes Mellitus—A Cross-Sectional Study
by Paulina Gaweł, Karolina Karcz, Natalia Zaręba-Wdowiak and Barbara Królak-Olejnik
Nutrients 2025, 17(21), 3324; https://doi.org/10.3390/nu17213324 - 22 Oct 2025
Abstract
Background: Women with gestational diabetes mellitus (GDM) are vulnerable to oxidative stress, yet limited data exist on the antioxidant potential of their breast milk. This study aimed to evaluate the antioxidant capacity and basic composition of colostrum in women with GDM compared to [...] Read more.
Background: Women with gestational diabetes mellitus (GDM) are vulnerable to oxidative stress, yet limited data exist on the antioxidant potential of their breast milk. This study aimed to evaluate the antioxidant capacity and basic composition of colostrum in women with GDM compared to healthy controls, focusing on total antioxidant capacity (TAC) and enzymatic antioxidants: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Methods: The study included 77 lactating mothers: 56 with gestational diabetes (15 managed with diet/exercise—GDM G1; 41 required insulin—GDM G2) and 21 healthy controls. Colostrum samples were collected on days 3–5 postpartum and analyzed for macronutrients and antioxidant enzymes. To enable comparisons across study groups and to explore associations with maternal characteristics, a range of statistical methods was applied. A taxonomic (classification) analysis was then performed using the predictors that best fit the data: study group membership, maternal hypothyroidism history (from the medical interview), and gestational weight gain. Results: TAC was significantly lower in the GDM G2 group compared to GDM G1 and controls (p = 0.001), with no differences in enzymatic antioxidants. The control group had the highest energy (p = 0.048) and dry matter content (p = 0.015), while protein, fat, and carbohydrate levels did not differ significantly. After dividing the study group into four clusters, based on maternal health factors, including GDM status and thyroid function, TAC levels differed significantly between clusters, with the highest values observed in Cluster 3 (healthy controls without thyroid dysfunction) and the lowest in Cluster 2 (GDM and hypothyroidism). Analysis of colostrum composition revealed significant differences in energy content (p = 0.047) and dry matter concentration (p = 0.011), while no significant differences were found in other macronutrients. Conclusions: Our findings suggest that maternal metabolic and endocrine conditions, such as GDM and thyroid dysfunction, may differentially influence the nutritional and functional properties of colostrum—particularly its antioxidant potential. Full article
(This article belongs to the Special Issue Maternal and Child Nutrition: From Pregnancy to Early Life)
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