Advanced Research on Gestational Diabetes: Focus on Fetal and Placental Endothelial Function

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2075

Special Issue Editors


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Guest Editor
Research Unit of Analytical Mass Spectrometry, Cell Biology and Biochemistry of Inborn Errors of Metabolism, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34/II, Graz 8036, Austria
Interests: inborn and aquired metabolic disorders; endothelial function; inflammation; fetal and adult endothelial cells; role of fetal sex in fetal programming

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Guest Editor
Research Unit Early Life Determinants, Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, Graz 8036, Austria
Interests: fetal programming; metabolic derangements in pregnancy; fetal endothelial cells; epigenetics

Special Issue Information

Dear Colleagues,

Influences in utero modulate the susceptibility to the development of non-communicable chronic diseases later in life. Accordingly, gestational diabetes (GDM) is associated with an increased risk for the development of cardiovascular diseases in the later life of the offspring. As a maternal metabolic disorder, GDM  establishes cardiovascular risk factors in the fetal circulation, including insulin resistance and a subtle pro-inflammatory environment which affects placental and fetal endothelial function. A dysfunctional placental endothelium with altered vascular architecture, flow rate or vascular resistance may consequently affect fetal heart development and manifest in cardiac changes. Moreover, the GDM environment may program the endothelial function and dysfunction in the long term through epigenetic changes. Thus, intrauterine exposure to cardiovascular risk factors may program and shape the future risk for endothelial dysfunction and cardiovascular disease.

This Special Issue will address the associations between maternal diabetes in pregnancy and placental and fetal endothelial dysfunction. Molecular mechanisms underlying the intrauterine programming of endothelial and cardiac dysfunction culminating in cardiovascular disease in later life are particularly of interest. Experimental work, epidemiological studies and review articles are welcome. Both human and animal studies are encouraged.

Dr. Silvija Cvitic
Dr. Ursula Hiden
Guest Editors

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Keywords

  • gestational diabetes
  • endothelial function
  • programming
  • placenta
  • cardiovascular risk factors
  • epigenetics

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Published Papers (1 paper)

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Review

14 pages, 1148 KiB  
Review
Is There a Relationship between Adverse Pregnancy Outcomes and Future Development of Atherosclerosis?
by Anastasia V. Poznyak, Victoria A. Khotina, Elena B. Zhigmitova, Vasily N. Sukhorukov, Anton Y. Postnov and Alexander N. Orekhov
Biomedicines 2023, 11(9), 2430; https://doi.org/10.3390/biomedicines11092430 - 31 Aug 2023
Cited by 3 | Viewed by 1797
Abstract
Cardiovascular disease is one of the main death causes globally. Effective cardiovascular risk management requires a thorough understanding of the mechanisms underlying the disorder. Establishing early markers of the disease allows a timely intervention and prevention of further atherosclerosis development. Multiple studies confirm [...] Read more.
Cardiovascular disease is one of the main death causes globally. Effective cardiovascular risk management requires a thorough understanding of the mechanisms underlying the disorder. Establishing early markers of the disease allows a timely intervention and prevention of further atherosclerosis development. Multiple studies confirm the correlation between pregnancy disorders and cardiovascular disease in the postpartum period. Moreover, over 30% of women experience adverse pregnancy outcomes. Thus, the examination of the links between these conditions and atherosclerotic cardiovascular disease may help to identify gender-specific risk factors. In this review, we will explore the association between several adverse pregnancy outcome conditions and atherosclerosis. The current analysis is based on the data from several recent studies on the mechanisms behind gestational diabetes, hypertensive disorders of pregnancy, miscarriages, and stillbirths and their implications for the female cardiovascular system. Full article
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