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Nutrients
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Relationship Among Essential Fatty Acids, Medical Herbs and Human Health
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Relationship Among Essential Fatty Acids, Medical Herbs and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: 15 March 2026 | Viewed by 798

Special Issue Editors

Prof. Dr. Chandra Shekhar H. Pareek

E-Mail Website
Guest Editor
Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Torun, Poland
Interests: multi-omics research; transcriptome analysis; nutrigenomics; metabolomics; bio-informatics
Dr. Piotr Adamski

E-Mail Website
Guest Editor
Department of Cardiology and Internal Medicine, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-094 Bydgoszcz, Poland
Interests: cardiology; pharmacokinetics; vascular medicine; antiplatelet therapy; pharmacodynamics
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Special Issue Information

Dear Colleagues,

It is widely acknowledged that incorporating supplementary diets, such as essential fatty acids and a broad spectrum of medicinal herbs, offers numerous benefits to human health. There is growing evidence that bioactive fatty acids and medicinal herbs offer multiple biological benefits to human health. Medicinal herbs contain active compounds that determine their diverse prophylactic/therapeutic behavior against many human diseases. Medicinal herbs have become increasingly important due to their potential beneficial health effects related to their nutritional composition, such as the presence of vitamins, phenols, anthocyanins, flavonoids, and tannins. For example, Andrographis paniculata contains a diterpenoid called andrographolide, which is a major bioactive component that is responsible for a wide range of biological activities such as antioxidant, anti-inflammatory, neuroprotective, and anti-cancer properties. Therefore, the primary objective of this Special Issue is to compile the most recent research on the dietary impact of both nutrients and non-nutrients containing bioactive compounds, including medicinal herbs on internal organ metabolism in the context of enhancing human health through genetic advancements. This Special Issue also welcomes submissions related to the latest discoveries regarding the effects of naturally occurring toxins in diet on internal organ metabolism in the context of improving human health through genetic interventions. Authors are encouraged to submit pertinent review articles, systematic reviews, meta-analyses, and original research contributions for potential inclusion in this Special Issue.

Prof. Dr. Chandra Shekhar H. Pareek
Dr. Piotr Adamski
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • internal organs (liver, kidneys, heart, stomach, small intestine, large intestine, urinary bladder, brain, lungs, etc.)
  • bioactive nutrients (PUFAs, etc.)
  • medicinal herbs (Andrographis paniculata, Silybum marianum curcuma longa, etc.)
  • aflatoxins (AFB1)
  • dietary effects
  • lifestyle diseases (NAFLD/NASH, ALD)
  • animal model (pigs, mouse, laboratory animals)
 

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Published Papers (1 paper)

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Review

27 pages, 2710 KB  
Review
Hepatoprotective Effect of Silymarin Herb in Prevention of Liver Dysfunction Using Pig as Animal Model
by Prarthana Sharma, Varun Asediya, Garima Kalra, Sharmin Sultana, Nihal Purohit, Kamila Kibitlewska, Wojciech Kozera, Urszula Czarnik, Krzysztof Karpiesiuk, Marek Lecewicz, Paweł Wysocki, Adam Lepczyński, Małgorzata Ożgo, Marta Marynowska, Agnieszka Herosimczyk, Elżbieta Redlarska, Brygida Ślaska, Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Paweł Grychnik, Athul P. Kurian, Kaja Ziółkowska-Twarowska, Katarzyna Chałaśkiewicz, Katarzyna Kępka-Borkowska, Ewa Poławska, Magdalena Ogłuszka, Rafał R. Starzyński, Hiroaki Taniguchi, Chandra Shekhar Pareek and Mariusz Pierzchałaadd Show full author list remove Hide full author list
Nutrients 2025, 17(20), 3278; https://doi.org/10.3390/nu17203278 - 18 Oct 2025
Viewed by 582
Abstract
Silymarin, a flavonolignan-rich extract of Silybum marianum, is widely recognized for its hepatoprotective potential. While rodent studies predominate, pigs (Sus scrofa) offer a more translationally relevant model due to their hepatic architecture, bile acid composition, and transporter expression, which closely [...] Read more.
Silymarin, a flavonolignan-rich extract of Silybum marianum, is widely recognized for its hepatoprotective potential. While rodent studies predominate, pigs (Sus scrofa) offer a more translationally relevant model due to their hepatic architecture, bile acid composition, and transporter expression, which closely resemble those of humans. This narrative review synthesises current evidence on the chemistry, pharmacokinetics, biodistribution, and hepatoprotective activity of silymarin in porcine models. Available studies demonstrate that when adequate intrahepatic exposure is achieved, particularly through optimised formulations, silymarin can attenuate oxidative stress, suppress inflammatory signalling, stabilise mitochondria, and modulate fibrogenic pathways. Protective effects have been reported across diverse porcine injury paradigms, including toxin-induced necrosis, ethanol- and diet-associated steatosis, metabolic dysfunction, ischemia–reperfusion injury, and partial hepatectomy. However, the evidence base remains limited, with few long-term studies addressing fibrosis or regeneration, and methodological heterogeneity complicates the comparison of data across studies. Current knowledge gaps in silymarin research include inconsistent chemotype characterization among plant sources, limited reporting of unbound pharmacokinetic parameters, and variability in histological scoring criteria across studies, which collectively hinder cross-study comparability and mechanistic interpretation. Advances in analytical chemistry, transporter biology, and formulation design are beginning to refine the interpretation of exposure–response relationships. Advances in analytical chemistry, transporter biology, and formulation design are beginning to refine the interpretation of exposure–response relationships. In parallel, emerging computational approaches, including machine-learning-assisted chemotype fingerprinting, automated histology scoring, and Bayesian exposure modeling, are being explored as supportive tools to enhance reproducibility and translational relevance; however, these frameworks remain exploratory and require empirical validation, particularly in modeling enterohepatic recirculation. Collectively, current porcine evidence supports silymarin as a context-dependent yet credible hepatoprotective agent, highlighting priorities for future research to better define its therapeutic potential in clinical nutrition and veterinary practice. Full article
(This article belongs to the Special Issue Relationship Among Essential Fatty Acids, Medical Herbs and Human Health)
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