Effects of Phytochemicals on Human Intestinal Microbiota
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".
Deadline for manuscript submissions: 25 September 2025 | Viewed by 70
Special Issue Editors
2. Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain
Interests: flavonoids; polyphenols; cocoa; hesperidin; methylxanthines; antioxidants; allergies; immunonutrition; immunomodulation; immune system; microbiota; antibody; sport; prebiotics; probiotics; postbiotics
Special Issues, Collections and Topics in MDPI journals
Interests: gut microbiota and microbiome; functional foods; clinical nutrition; metagenomics and microbial genomics; metabolomics; metabolic health
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Phytochemicals, bioactive compounds derived from plants, play a significant role in human health, primarily through their interactions with the gut microbiota. Increasing evidence suggests that polyphenols, flavonoids, alkaloids, terpenes, and other phytochemicals can influence microbial composition, metabolic pathways, and gut homeostasis. These compounds can promote the growth of beneficial bacteria, inhibit the proliferation of pathogens, and become metabolized by gut microbes into bioactive metabolites with potential health benefits.
This Special Issue of Nutrients aims to explore the bidirectional relationship between phytochemicals and gut microbiota, with a particular emphasis on their impact on metabolic health, immune function, and disease prevention.
We invite the submission of original in vitro, preclinical, clinical research, and comprehensive reviews focusing on the following topics:
- The mechanisms by which phytochemicals modulate the gut microbiota composition and function.
- The role of microbial metabolites derived from phytochemicals in promoting human health.
- Interactions between phytochemicals, gut microbiota, and metabolic disorders (e.g., obesity, diabetes, and metabolic conditions).
- The influence of phytochemicals on gut–brain axis communication.
- Dietary strategies using phytochemicals for microbiota-targeted therapies.
This Special Issue offers a platform to advance our understanding of how phytochemicals interact with the gut microbiota to influence human health, paving the way for the development of novel therapeutic and nutritional strategies.
We look forward to receiving your valuable contributions.
Dr. Malen Massot-Cladera
Dr. Adele Costabile
Guest Editors
Manuscript Submission Information
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Keywords
- phytochemicals
- phytochemical-rich diets
- microbiota
- microbiota modulation
- dietary bioactives
- bioactive compounds
- functional foods: polyphenols
- human nutrition
- gut health
- metabolome
- microbial metabolite
- gut–brain axis
- microbiota-induced metabolic disorders
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