Nutrient Interaction, Metabolic Adaptation and Healthy Aging
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".
Deadline for manuscript submissions: closed (25 January 2026) | Viewed by 1901
Special Issue Editors
Interests: animal experiments on the pathogenesis of diseases (e.g., nutrients, interactions, metabolic reprogramming, mechanisms)
Interests: population epidemiology and cohort studies (e.g., nutritional epidemiology, metabolic dysfunction-associated steatotic liver disease, type 2 diabetes, cardiovascular disease)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aging is a complex and multifactorial process that is determined by many factors, including genetic background, metabolic regulation, and external environmental factors. Unhealthy aging is a major risk factor for the development of many diseases, prominently including neurodegenerative disease, cancer, diabetes, and cardiovascular disease. In the central nervous system, microglia can quickly adapt to varying nutrient availability, transitioning from glycolysis to other metabolic pathways such as glutaminolysis under acute stress. Under neuroinflammatory conditions, metabolic reprogramming occurs primarily through a shift from oxidative glycolysis to aerobic glycolysis, essential for proper cytokine release. In tumorigenesis, beyond the metabolic reprogramming of the glucose metabolism, the important role of other amino acids, such as serine, glycine, and methionine, gradually becomes clear. Diabetic neuropathy is often a formidable challenge in the clinical management of diabetes, markedly diminishing the patient's quality of life, and is now liked to toxic sphingolipids caused by metabolic reprogramming due to serine deficiency. Other nutrients, such as elenium and vitamin K, have recently become to be considered as key regulators of ferroptosis—which is a newly identified novel form of regulated, non-apoptotic cell death caused by iron-overload-dependent phospholipid peroxidation—and then influences cell aging, tumorigenesis, and cell death.
We welcome original in vitro, animal, and human studies, as well as reviews of the scholarship around aging. Submissions that address the mechanisms of genetic and epigenetic adaptation and metabolic programming among metabolic pathways, the interactions of nutrients during healthy aging, as well as nutrient imbalance under disease conditions and nutrient rebalancing for disease prevention and treatment are strongly encouraged.
In this Special Issue, we focus on high-quality studies on the interactions and rebalancing of nutrients that benefit healthy aging.
Dr. Zhenwu Huang
Dr. Shunming Zhang
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- nutrients
- healthy aging
- genetic and epigenetic mechanisms
- metabolic reprogramming
- interaction
- intervention
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