nutrients-logo

Journal Browser

Journal Browser

Lipid Metabolism and Nutritional Status in Patients Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 15 November 2025 | Viewed by 679

Special Issue Editor


E-Mail Website
Guest Editor
Faculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan
Interests: lipids; lipoproteins; LDL; HDL; lipid hydroperoxide; lipid droplets; mitochondria; oxidative stress; antioxidants; functional foods; lipidomics; non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH)

Special Issue Information

Dear Colleagues,

The number of patients with non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH), is increasing globally. It is believed that the onset of NASH is contributed to by abnormalities in the lipid metabolism and increased oxidative stress. Indeed, the onset of NASH has been linked to various diseases, such as metabolic syndrome, obesity, and diabetes. Most of the diseases may be explained as oxidative stress-related diseases. In recent years, the name and definition of NAFLD/NASH have been revised to MASLD/MASH, and it is attracting attention again. Research into the pathogenesis, prevention, treatment, and biomarkers of the disease has not been completed. To reduce its prevalence, solving these issues is an urgent task.

In this Special Issue of Nutrients, entitled ‘Lipid Metabolism and Nutritional Status in Patients Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)’, we would consider and encourage researchers to submit articles that propose strategies for the early detection of MASLD/MASH, elucidate the possible risk factors of MASLD/MASH in vitro or in vivo, or propose possible interventions through physical exercise and nutrition- or food-derived treatments.

Dr. Toshihiro Sakurai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • MASLD
  • MASH
  • fibrosis
  • lipoprotein
  • oxidized lipoproteins
  • hydroperoxide
  • nutrition
  • prevention
  • treatment
  • biomarker

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

17 pages, 3215 KB  
Article
Matcha Green Tea Improves Cafeteria-Diet-Induced NAFLD by Modulating the Gut Microbiota in Rats
by Ho-Ching Chong, Shu-Ting Tang, Yu-Chieh Tseng, Suh-Ching Yang, Yasuo Watanabe, Shizuo Yamada, Yu-Chen S. H. Yang and Ya-Ling Chen
Nutrients 2025, 17(19), 3051; https://doi.org/10.3390/nu17193051 - 24 Sep 2025
Viewed by 474
Abstract
Background: The aim of this study was to investigate the effects of matcha on lipid metabolism, insulin resistance (IR), inflammation, and gut dysbiosis in non-alcoholic fatty liver disease (NAFLD) induced by a cafeteria diet. Methods: Forty-eight 7-week-old male Wistar rats were divided into [...] Read more.
Background: The aim of this study was to investigate the effects of matcha on lipid metabolism, insulin resistance (IR), inflammation, and gut dysbiosis in non-alcoholic fatty liver disease (NAFLD) induced by a cafeteria diet. Methods: Forty-eight 7-week-old male Wistar rats were divided into six groups (n = 8), including a control group (C), C + 0.2% matcha group (C + 0.2%), C + 1% matcha group (C + 1%), cafeteria group (Caf), Caf + 0.2% matcha group (Caf + 0.2%), and Caf + 1% matcha group (Caf + 1%). All rats were sacrificed at the end of the 12th week of the experiment. A one-way analysis of variance (ANOVA), followed by a Fisher’s post hoc test, was used to determine the significant differences among each of the groups. Results: The results indicated that plasma experiment triglycerides (TGs) significantly increased in the Caf group compared to the C group, and significantly decreased TG levels were found in the Caf + 1% group compared to the Caf group. In addition, the liver total cholesterol and TG had significantly increased in the Caf group, while the 0.2% Matcha intervention can mitigate hepatic lipid accumulation. Blood sugar, serum insulin, the homeostasis model assessment of IR (HOMA-IR), and plasma leptin significantly increased in the Caf group and were significantly lower in the Caf + 0.2% and Caf + 1% groups. Hepatic cytokines significantly increased in the Caf group, while, on the other hand, significantly lower concentrations were found in the Caf + 1% group. In addition, beneficial bacteria including Akkermansia, Faecalibacterium, and Parabacteroides increased after matcha supplementation. Conclusions: These results suggested that 12 weeks of a cafeteria diet can induce abnormal lipid metabolism, IR, liver inflammation, and an altered gut microbiotic composition, while both the 0.2% and 1% matcha interventions might regulate obesity, lipid accumulation, IR, and inflammatory responses, and help maintain a healthier gut microbiota, which may then ameliorate the development of NAFLD. Full article
Show Figures

Figure 1

Back to TopTop