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Optimizing Sleep and Nutrition for Improving Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (25 April 2025) | Viewed by 957

Special Issue Editors


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Guest Editor
Department of Biomedical Sciences for Health, University of Milan, Via Giuseppe Colombo 71, 20133 Milan, Italy
Interests: physical activity; sleep; circadian rhythms; rest–activity circadian rhythms; chronotypes; health
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Department of Experimental Oncology, Nutritional Research and Metabolomics Unit, Via G. VENEZIAN 1 , 20133 Milan, Italy
Interests: diet; physical activity; sleep; circadian rhythms; metabolic syndrome; breast cancer
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biomedical Sciences for Health, University of Milan, Via Giuseppe Colombo 71, 20133 Milan, Italy
Interests: physical activity; sleep; circadian rhythms; restactivity circadian rhythms; chronotypes; health; eating disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Achieving and maintaining good health is an increasingly sought-after goal, yet this is often difficult to attain. Among the many factors influencing this objective, sleep quality and nutritional status are increasingly recognized as key components that contribute to physical, mental, and psychological well-being. New, effective, and efficient strategies are required to improve and optimize sleep quality and nutritional status, thereby fostering positive health outcomes.

This Special Issue aims to highlight original research, reviews, and case reports, as well as hypotheses and theories, that can offer new insights and directions for either improving or maintaining both sleep quality and nutritional status. Contributions  may focus on the general population or specific target groups, such as individuals with certain medical conditions, distinct age groups, or those subjected to particular socio-economic, cultural, or health conditions. Finally, the topics may encompass all three orders of health prevention and care.

Dr. Lucia Castelli
Dr. Eleonora Bruno
Dr. Letizia Galasso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • health promotion
  • sleep quality
  • physical activity
  • nutritional status
  • physical well-being
  • mental well-being
  • improvement strategies
  • optimization strategies

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Published Papers (1 paper)

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Review

12 pages, 1951 KiB  
Review
Vitamin B3 Ameliorates Sleep Duration and Quality in Clinical and Pre-Clinical Studies
by Carleara Weiss
Nutrients 2025, 17(12), 1982; https://doi.org/10.3390/nu17121982 - 12 Jun 2025
Viewed by 508
Abstract
NAD+ is a fundamental molecule participating as a redox cofactor in several metabolic reactions and has a neuroprotective role associated with oxidate stress. Despite its critical role, NAD+ levels sharply decline with age, contributing to the pathogenesis of aging-related diseases. Supplementation [...] Read more.
NAD+ is a fundamental molecule participating as a redox cofactor in several metabolic reactions and has a neuroprotective role associated with oxidate stress. Despite its critical role, NAD+ levels sharply decline with age, contributing to the pathogenesis of aging-related diseases. Supplementation with nicotinamide riboside (NR), also known as a form of vitamin B3, a biochemical precursor of NAD+, may replenish this depletion. Background/Objectives: Mounting evidence suggests that dietary supplementation with NR, a form of vitamin B3 and a biochemical precursor of NAD+, enhances NAD+ bioavailability and prevents the detrimental effects on sleep, cognitive function, mitochondrial function, and insulin sensitivity. However, there is a paucity of studies focused on how NR administration affects sleep patterns. This narrative review summarizes the current state of scientific knowledge on the effects of nicotinamide riboside supplementation on sleep. Results: Pre-clinical studies indicate that NR enhances the performance of the clock genes BMAL1 and PER2, and ameliorates chronic sleep deprivation-induced cognitive impairment, potentially by alleviating oxidative stress and mitochondrial impairment in microglia. NR supplementation also increased REM sleep and reduced NREM sleep by approximately 17%. In human studies, NR improved sleep efficiency in young and middle-aged male individuals with insomnia. It also improved sleep quality and reduced fatigue and drowsiness in older adults. More research is warranted to understand the impacts of NR on sleep for women. Conclusions: NR supplementation is a reliable and effective alternative to boost NAD+ levels and may ameliorate sleep patterns. Full article
(This article belongs to the Special Issue Optimizing Sleep and Nutrition for Improving Human Health)
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