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Nutrients
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Nutritional Challenges for Healthy Aging: Prevention, Screening and Intervention
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Nutritional Challenges for Healthy Aging: Prevention, Screening and Intervention

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".

Deadline for manuscript submissions: closed (25 January 2025) | Viewed by 4519

Special Issue Editor

Prof. Dr. Moustapha Dramé

E-Mail Website
Guest Editor
Department of Clinical Research and Innovation, University Hospitals of Martinique, Fort-de-France, F-97200 Martinique, France
Interests: clinical epidemiology; geriatrics; gerontology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Poor nutrition status is very common in older adults and is associated with poorer health outcomes. Healthy ageing is therefore a major public health concern, particularly in the context of the global ageing of populations.

There are many strategies for healthy ageing. Nutritional management during the lifecourse is one of the strongest factors in successful ageing. Nutritional interventions can take place to prevent poor health outcomes. Indeed, nutrition is probably of primary importance in older adults in order to avoid the consequences of acute or chronic diseases, such as infections, longer hospital stays, loss of autonomy, and increased mortality.

The aim of this Special Issue is to provide an update on nutrition interventions that contribute to successful ageing. Therefore, to contribute to this Special Issue, please feel free to submit review or original articles on the influence of diet, dietary supplements, weight changes, etc., on healthy ageing. This knowledge will help to improve support and prevention strategies for older adults.

Prof. Dr. Moustapha Dramé
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutritional intervention
  • healthy ageing
  • successful ageing
  • lifecourse
  • prevention

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Published Papers (2 papers)

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Research

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19 pages, 1426 KiB  
Article
Enhancement of Lower Limb Muscle Strength and Reduction of Inflammation in the Elderly: A Randomized, Double-Blind Clinical Trial Comparing Lacticaseibacillus paracasei PS23 Probiotic with Heat-Treated Supplementation
by Mon-Chien Lee, Yi-Ju Hsu, Hung-Jen Yang and Chi-Chang Huang
Nutrients 2025, 17(3), 463; https://doi.org/10.3390/nu17030463 - 27 Jan 2025
Cited by 2 | Viewed by 1683
Abstract
Background: As individuals age, there is a gradual loss of muscle mass and strength, which not only impairs physical functionality but also heightens the risk of falls and diminishes independence among older adults. Probiotics have emerged as a focus of recent research [...] Read more.
Background: As individuals age, there is a gradual loss of muscle mass and strength, which not only impairs physical functionality but also heightens the risk of falls and diminishes independence among older adults. Probiotics have emerged as a focus of recent research due to their potential role in enhancing muscle health via the gut–muscle axis. This study evaluates the effects of live and heat-treated Lacticaseibacillus paracasei PS23 (PS23) supplementation on muscle strength and mass in the elderly. Methods: This study recruited 119 participants, aged 65–85 years, and randomly assigned them to receive a placebo (0 × 1010 CFU/day), L-PS23 (live PS23, 2 × 1010 CFU/day), or HT-PS23 (heat-treated PS23, 2 × 1010 cells/day) for a duration of 12 weeks. Assessments of blood pressure, body composition, muscle strength, functional physical fitness, and biochemical parameters were conducted at baseline, 6 weeks, and 12 weeks. Results: Among the 100 subjects who completed the trial, supplementation with both L-PS23 and HT-PS23 significantly enhanced lower limb muscle strength and endurance compared to the placebo (p < 0.05), although no significant differences were observed in muscle mass or upper limb muscle strength across the groups. Additionally, while most muscle anabolism-related markers showed no significant changes, both supplements effectively decreased inflammatory markers related to aging—C-reactive protein (CRP: L-PS23, p = 0.016; HT-PS23, p = 0.013) and interleukin-6 (IL-6: L-PS23, p = 0.003; HT-PS23, p < 0.001)—and increased interleukin-10 levels (L-PS23, p = 0.014; HT-PS23, p = 0.005). Notably, only the HT-PS23 group demonstrated a significant increase in testosterone levels (p = 0.029). Conclusions: 12 weeks of supplementation with L-PS23 and HT-PS23 improved lower limb muscle strength and endurance but did not significantly enhance muscle mass in older adults. Both supplements also proved effective in reducing inflammatory markers and elevating testosterone levels. HT-PS23, administered as a heat-treated probiotic, provided more pronounced benefits to the elderly compared with its probiotic counterpart, L-PS23. Full article
(This article belongs to the Special Issue Nutritional Challenges for Healthy Aging: Prevention, Screening and Intervention)
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Review

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34 pages, 1540 KiB  
Review
Body Composition and Senescence: Impact of Polyphenols on Aging-Associated Events
by Tanila Wood dos Santos, Quélita Cristina Pereira, Isabela Monique Fortunato, Fabrício de Sousa Oliveira, Marisa Claudia Alvarez and Marcelo Lima Ribeiro
Nutrients 2024, 16(21), 3621; https://doi.org/10.3390/nu16213621 - 25 Oct 2024
Cited by 1 | Viewed by 2515
Abstract
Aging is a dynamic and progressive process characterized by the gradual accumulation of cellular damage. The continuous functional decline in the intrinsic capacity of living organisms to precisely regulate homeostasis leads to an increased susceptibility and vulnerability to diseases. Among the factors contributing [...] Read more.
Aging is a dynamic and progressive process characterized by the gradual accumulation of cellular damage. The continuous functional decline in the intrinsic capacity of living organisms to precisely regulate homeostasis leads to an increased susceptibility and vulnerability to diseases. Among the factors contributing to these changes, body composition—comprised of fat mass and lean mass deposits—plays a crucial role in the trajectory of a disability. Particularly, visceral and intermuscular fat deposits increase with aging and are associated with adverse health outcomes, having been linked to the pathogenesis of sarcopenia. Adipose tissue is involved in the secretion of bioactive factors that can ultimately mediate inter-organ pathology, including skeletal muscle pathology, through the induction of a pro-inflammatory profile such as a SASP, cellular senescence, and immunosenescence, among other events. Extensive research has shown that natural compounds have the ability to modulate the mechanisms associated with cellular senescence, in addition to exhibiting anti-inflammatory, antioxidant, and immunomodulatory potential, making them interesting strategies for promoting healthy aging. In this review, we will discuss how factors such as cellular senescence and the presence of a pro-inflammatory phenotype can negatively impact body composition and lead to the development of age-related diseases, as well as how the use of polyphenols can be a functional measure for restoring balance, maintaining tissue quality and composition, and promoting health. Full article
(This article belongs to the Special Issue Nutritional Challenges for Healthy Aging: Prevention, Screening and Intervention)
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