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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 15 May 2026 | Viewed by 2789

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Special Issue Editors

Dr. Jeanette Mary Andrade

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Guest Editor

Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
Interests: chronic kidney disease; dietary habits; inflammation

Dr. Yoshiyuki Morishita

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Division of Nephrology, Department of Internal Medicine, Jichi Medical University. 3311-1, Yakushiji, Shimutsuke 329-0498, Tochigi, Japan
Interests: chronic kidney disease; microRNA; gene delivery
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Prof. Dr. Ilia Beberashvili

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Division of Nephrology, Shamir Medical Center (Assaf Harofeh), Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
Interests: nutritional assessment; malnutrition; sarcopenia; inflammation; hemodi-alysis; chronic kidney disease

Prof. Dr. Mona Boaz

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Department of Nutrition Sciences, Ariel University, Ariel 40700, Israel
Interests: epidemiolgoy; nutrition; obesity; malnutrition; nephrology; type 2 diabetes
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Special Issue Information

Dear Colleagues,

Nutrition plays a pivotal role in the prevention and management of kidney disease, and there is growing recognition of its impact on metabolic health and disease progression. The interplay between kidney function, nutrient metabolism, and dietary interventions is complex and evolving, warranting deeper investigation. This Special Issue will focus on the critical nexus of kidney nutrition and metabolism, highlighting the latest advances in nutritional science, dietary strategies, and metabolic regulation in both acute and chronic kidney conditions. Topics will include nutrient handling in kidney disease, the role of dietary patterns and specific nutrients, nutritional assessment tools, and the impact of diet on inflammation, oxidative stress, and cardiovascular risk in this population. We also welcome studies on novel therapeutic approaches, including precision nutrition and plant-based diets, and their influence on clinical outcomes. By gathering interdisciplinary research from the nephrology, nutrition, and metabolic science fields, this issue aims to inform clinical practice, support evidence-based dietary recommendations, and inspire innovative strategies to improve patient care and quality of life for individuals with kidney disease.

This Special Issue of Nutrients entitled “Kidney Nutrition and Metabolism” welcomes original research articles and reviews of the literature concerning this important topic.

Dr. Jeanette Mary Andrade
Dr. Yoshiyuki Morishita
Prof. Dr. Ilia Beberashvili
Prof. Dr. Mona Boaz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

kidney disease
nutrition
metabolism
dietary habits
clinical studies
observational studies
systematic review/meta-analyses

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Research

20 pages, 628 KB

Open AccessArticle

Nutritional Status and Dietary Assessment in Kidney Transplant Recipients

by Martyna Magalska and Sylwia Małgorzewicz

Nutrients 2026, 18(7), 1145; https://doi.org/10.3390/nu18071145 - 2 Apr 2026

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Abstract

Background: Proper nutrition plays a crucial role in post-kidney transplantation care, influencing graft function, body composition, and the risk of metabolic complications. Protein intake is of particular importance due to its role in preserving muscle mass and preventing protein energy wasting. Objective: This study aimed to assess dietary intake, with emphasis on protein consumption, and to analyze its associations with nutritional status, anthropometric indices, and metabolic complications in kidney transplant recipients. Materials and Methods: A cross-sectional study was conducted in 71 adult kidney transplant recipients. Dietary intake was assessed using a 24 h dietary recall and the FFQ-6 questionnaire. Anthropometric measurements were performed, and multiple indices of body composition and central obesity were calculated. Associations between dietary intake, anthropometric parameters, age, and kidney graft function were analyzed. Results: Mean BMI was within the upper normal range; however, a high prevalence of central adiposity was observed. Age was positively correlated with indices of visceral obesity (ABSI, AVI, WHtR, and CI). Protein intake was positively associated with calf circumference, indicating a relationship with muscle mass preservation. Dietary analysis revealed excessive sodium intake and insufficient intake of potassium, calcium, vitamin D, and unsaturated fatty acids. Post-transplant diabetes mellitus was present in 25.35% of participants. Conclusions: Kidney transplant recipients frequently present with unfavorable body composition and dietary imbalances that are not adequately reflected by BMI alone. Comprehensive nutritional assessment and individualized dietary counseling are important strategies that may help reduce the risk of metabolic complications and support long-term transplant outcomes. Full article

(This article belongs to the Special Issue Kidney Nutrition and Metabolism)

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16 pages, 864 KB

Open AccessArticle

by Ana Casaux-Huertas, María Luz Sánchez-Tocino, Marta San Juan-Miguelsanz, Julia Audije-Gil, Neydu Romero-Lugo, Sonia Muñoz-Pilar, Fabiola Da Pena-Vielba, David Hernan-Gascueña, Paula Manso-Del Real, Soraya Escribano-Loma, Cristina Cubas Sánchez-Beato, María Dolores Arenas-Jiménez, Research Unit, Fundación Renal Española and FRAGILDIAL Working Group, Fundación Renal Española

Nutrients 2026, 18(1), 124; https://doi.org/10.3390/nu18010124 - 30 Dec 2025

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Abstract

Post-dialysis fatigue is one of the most frequent and limiting symptoms among patients undergoing hemodialysis (HD), characterized by intense physical exhaustion that may persist beyond the treatment session. Sleep disturbances frequently coexist with fatigue and may contribute to overall symptom burden. Nutritional status has been identified as a potential determinant of fatigue severity. Understanding these relationships may help identify associated factors and guide multidisciplinary interventions. Objectives: To assess the prevalence and intensity of fatigue in patients receiving HD, to describe the burden of sleep disturbances, and to analyze their association with nutritional status and various clinical, dialytic, and sociodemographic variables. Methods: A cross-sectional descriptive study was conducted between November and December 2024 in adults with chronic kidney disease undergoing maintenance HD. Fatigue and sleep disturbances were assessed using brief patient-reported outcome items adapted from PROMIS item bank concepts and analyzed as separate subscales. Nutritional status was evaluated using the Mini Nutritional Assessment–Short Form (MNA-SF). Sociodemographic, clinical, dialytic, and laboratory variables were collected. Statistical analyses were performed using SPSS v29, applying association and correlation tests (p ≤ 0.05). Results: A total of 729 patients were included (67.1% men), with a mean age of 67.7 ± 14.5 years. Clinically relevant fatigue was reported by approximately 50% of participants, with around 20% presenting severe fatigue. Sleep disturbances affected nearly 60% of patients, with severe impairment reported in approximately 30%. Regarding nutritional status, 61.9% had normal nutrition, 33.2% were at risk of malnutrition, and 4.9% were malnourished. Fatigue was significantly associated with female sex (p < 0.001), longer time on hemodialysis (p < 0.001), greater weekly dialysis exposure (p = 0.012), and poorer nutritional status (p = 0.003). The absence of residual urine output showed a borderline association with fatigue (p = 0.059) but was significantly associated with sleep disturbances (p = 0.002). Sleep disturbance scores were also significantly associated with lower levels of albumin, total proteins, and transferrin. No associations were observed between fatigue and age, BMI, comorbidity, ultrafiltration rate, or biochemical parameters. Conclusions: Fatigue is a highly prevalent and clinically relevant symptom in patients undergoing HD and is closely associated with nutritional status and dialysis-related factors. Sleep disturbances are also highly prevalent and may act as an important modulating factor, potentially amplifying fatigue, particularly in patients with greater biological vulnerability or loss of residual kidney function. The systematic use of patient-reported outcome measures (PROMs) to assess fatigue and sleep, together with nutritional evaluation, may facilitate the early identification of vulnerable patients and guide targeted strategies to reduce symptom burden and improve quality of life. Full article

(This article belongs to the Special Issue Kidney Nutrition and Metabolism)

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