Advances in Molecular Mechanisms of Neurodegenerative Diseases
A special issue of Neurology International (ISSN 2035-8377).
Deadline for manuscript submissions: 30 November 2025 | Viewed by 20
Special Issue Editors
Interests: neuroscience; neurodegeneration; endocytic mechanisms; Alzheimer’s disease; Parkinson’s disease; spinocerebellar ataxias type 2 (SCA2); Amyotrophic lateral sclerosis (ALS); RNA sequencing; super-resolution microscopy; protein aggregation; proteomics; rodent models; therapeutic development
Interests: neuroscience; neurodegeneration; Alzheimer’s disease; Parkinson’s disease; amyloid proteins aggregation; prion protein aggregation; neurodegenerative disease; biomarkers development; plasma and CSF biomarkers development; neuronal cell culture development
Interests: neurodegenerative diseases including Parkinson’s disease; Huntington’s disease; other movement disorders; Alzheimer’s disease; neuroimmune diseases including: multiple sclerosis, inflammatory neuropathies, myasthenia gravis
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Special Issue Information
Dear Colleagues,
Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, among others, represent a significant and growing public health challenge. Various key factors contribute to the development of these diseases, such as genetic mutations, protein misfolding and aggregation, neuroinflammation, mitochondrial and oxidative pathways, impaired clearance pathways, epigenetic changes, etc. Despite tremendous progress in research, the precise molecular mechanisms driving these diseases remain incompletely understood, hindering the development of effective therapies. This Special Issue, “Advances in Molecular Mechanisms of Neurodegenerative Diseases”, seeks to compile cutting-edge research that elucidates the complex molecular and cellular processes underlying neurodegeneration.
This Special Issue aims to explore the latest research findings and state-of-the-art reviews on various aspects of neurodegenerative diseases, including molecular and cellular mechanisms of amyloid protein aggregation, disease pathology associated with neuroinflammation, mitochondrial abnormalities, oxidative stress, dysfunctions in lysosomal, endocytic, and autophagy-related pathways, and genetic and epigenetic factors to advance our understanding of neurodegeneration and to further facilitate early diagnosis and effective therapeutic development.
Research topics of interest include (but not limited to) the following:
- Understanding the molecular and cellular mechanisms of amyloid protein aggregation.
- Understanding the molecular and cellular mechanisms for mitochondrial anomalies.
- Understanding the autophagy-related dysfunctions in various neurodegenerative diseases.
- Identifying novel biomarkers and genetic factors for early diagnosis.
- Discovering therapeutic strategies for the prevention and treatment of neurodegenerative diseases.
Dr. Pravin Hivare
Dr. Joshna Gadhavi
Dr. Cristoforo Comi
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neurology International is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegenerative diseases
- molecular mechanisms
- protein aggregation
- endocytic pathways
- mitochondrial dysfunction
- oxidative stress
- neuroinflammation
- autophagy
- genetics
- therapeutic targets
- biomarker identification
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