Advances in Molecular Mechanisms of Neurodegenerative Diseases

Dear Colleagues,

Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, among others, represent a significant and growing public health challenge. Various key factors contribute to the development of these diseases, such as genetic mutations, protein misfolding and aggregation, neuroinflammation, mitochondrial and oxidative pathways, impaired clearance pathways, epigenetic changes, etc. Despite tremendous progress in research, the precise molecular mechanisms driving these diseases remain incompletely understood, hindering the development of effective therapies. This Special Issue, “Advances in Molecular Mechanisms of Neurodegenerative Diseases”, seeks to compile cutting-edge research that elucidates the complex molecular and cellular processes underlying neurodegeneration.

This Special Issue aims to explore the latest research findings and state-of-the-art reviews on various aspects of neurodegenerative diseases, including molecular and cellular mechanisms of amyloid protein aggregation, disease pathology associated with neuroinflammation, mitochondrial abnormalities, oxidative stress, dysfunctions in lysosomal, endocytic, and autophagy-related pathways, and genetic and epigenetic factors to advance our understanding of neurodegeneration and to further facilitate early diagnosis and effective therapeutic development.

Research topics of interest include (but not limited to) the following:

1. Understanding the molecular and cellular mechanisms of amyloid protein aggregation.
2. Understanding the molecular and cellular mechanisms for mitochondrial anomalies.
3. Understanding the autophagy-related dysfunctions in various neurodegenerative diseases.
4. Identifying novel biomarkers and genetic factors for early diagnosis.
5. Discovering therapeutic strategies for the prevention and treatment of neurodegenerative diseases.

Dr. Pravin Hivare
Dr. Joshna Gadhavi
Dr. Cristoforo Comi
Guest Editors

Manuscript Submission Information

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